DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fa2h and AGMO

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_006715793.1	Gene:	AGMO / 392636	HGNCID:	33784	Length:	456	Species:	Homo sapiens

Alignment Length:	315	Identity:	55/315 - (17%)
Similarity:	87/315 - (27%)	Gaps:	142/315 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KPKSSQRETLHHDEDGTLRQRP-------------RETEDKNNNQVDDSMEHLVDWSKAMLPQI- 130
            ||..:..:||....|...:..|             ...:.|...::||::..:.....:.||.:
Human    24 KPSETSFQTLEEVPDYVKKATPFFISLMLLELVVSWILKGKPPGRLDDALTSISAGVLSRLPSLF 88

  Fly   131 ---ANITDCYDEWVHKPVDRPLRLFD-PWYLEMCTKTPWWLVPLFWIPVIVKCAVEEFTTAWQDS 191
               ..:|.....|.:      .|||: ||      .:||                     .|. |
Human    89 FRSIELTSYIYIWEN------YRLFNLPW------DSPW---------------------TWY-S 119

  Fly   192 NQLAVFSGYFLFGVLLWSFLEYTLHRWVFHVKLSNKSGSWLCTFHFMIHGLHHK----------- 245
            ..|.|..||:.|            ||....|.:     .|..      |..||.
Human   120 AFLGVDFGYYWF------------HRMAHEVNI-----MWAG------HQTHHSSEDYNLSTALR 161

  Fly   246 ----------VPFDPMRLVFPPLPGAVLAAV-------IYT-------PLSFVLSHPRVILSGAL 286
                      :.:.|:.|..||...||....       |:|       ||..:|:.|
Human   162 QSVLQIYTSWIFYSPLALFIPPSVYAVHLQFNLLYQFWIHTEVINNLGPLELILNTP-------- 218

  Fly   287 AGYLCYDMMHYYLHYGNPSLWAFVHMKRYHHHHHFSHQTLGYGISSPLWDVVFKT 341
                    .|:.:|:|.         .||....:::...:       :||.:|.|
Human   219 --------SHHRVHHGR---------NRYCIDKNYAGVLI-------IWDKIFGT 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	45/263 (17%)
AGMO	XP_006715793.1	ERG3	43..255	CDD:225546	50/296 (17%)
AGMO	XP_006715793.1	FA_hydroxylase	120..249	CDD:282034	32/183 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900