DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fa2h and Fa2h

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_835187.2	Gene:	Fa2h / 338521	MGIID:	2443327	Length:	372	Species:	Mus musculus

Alignment Length:	345	Identity:	130/345 - (37%)
Similarity:	193/345 - (55%)	Gaps:	42/345 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YDLSRFMHKHPGGINTLKGLNSGDMTARFLKAPP--HSDAA-----MYLMREYKIDPEDSRKPKS 83
            |||:.|:..||||...|......|::|. |..||  |||.|     .|.:.|.:.||:|.
Mouse    34 YDLTSFVRHHPGGEQLLLARAGQDISAD-LDGPPHRHSDNARRWLEQYYVGELRADPQDP----- 92

  Fly    84 SQRETLHHDEDGTLRQRPRETED---KNNNQVDDSMEHLVDWSKAMLPQIANITDCYDEWVHKPV 145
                    .|:|.:.....:..|   :...:|.|..:.||||.|.:|.|:.::.:.||||||:||
Mouse    93 --------TENGAVASAETQKTDPALEPQFKVVDWDKDLVDWQKPLLWQVGHLGEKYDEWVHQPV 149

  Fly   146 DRPLRLFDPWYLEMCTKTPWWLVPLFWIPVIVKCAVEEFTTAWQDSNQL--------------AV 196
            .||:|||....:|..:||.|:.||:.|:|:::..:...:.|..||:.:|              :|
Mouse   150 ARPIRLFHSDLIEAFSKTVWYSVPIIWVPLVLYLSWSYYRTLTQDNIRLFASLTREYSMMMPESV 214

  Fly   197 FSGYFLFGVLLWSFLEYTLHRWVFHVKLSNKSGSWLCTFHFMIHGLHHKVPFDPMRLVFPPLPGA 261
            |.|.|:.|:|.|:|:||.:||::||:|..:.| .:|...||::||.|||.|||..||||||:|.:
Mouse   215 FIGLFVLGMLFWTFVEYVIHRFLFHMKPPSNS-HYLIMLHFVMHGQHHKAPFDGSRLVFPPVPAS 278

  Fly   262 VLAAVIYTPLSFVLSHP--RVILSGALAGYLCYDMMHYYLHYGNPSLWAFVH-MKRYHHHHHFSH 323
            ::.|..|..|..:|...  .:|.:|.|.||:.|||.|||||:|:|...:::: ||.:|..|||.:
Mouse   279 LVIAFFYVFLRLILPETVGGIIFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYNMKAHHVKHHFEY 343

  Fly   324 QTLGYGISSPLWDVVFKTRI 343
            |..|:|||:.|||..|.|.|
Mouse   344 QKSGFGISTKLWDYFFHTLI 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597	20/53 (38%)
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	100/240 (42%)
Fa2h	NP_835187.2	Cyt-b5	11..85	CDD:278597	19/51 (37%)
		FA_hydroxylase	124..372	CDD:294712	101/241 (42%)
		ERG3	<208..365	CDD:225546	70/157 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837982
Domainoid	1	1.000	146	1.000	Domainoid score	I4537
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56284
Inparanoid	1	1.050	234	1.000	Inparanoid score	I3402
Isobase	1	0.950	-	0	Normalized mean entropy	S2267
OMA	1	1.010	-	-		QHG55743
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004076
OrthoInspector	1	1.000	-	-		oto94295
orthoMCL	1	0.900	-	-		OOG6_103477
Panther	1	1.100	-	-	LDO	PTHR12863
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R279
SonicParanoid	1	1.000	-	-		X2828
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740