DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fa2h and ch25hl1.1

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001017865.1	Gene:	ch25hl1.1 / 336673	ZFINID:	ZDB-GENE-030131-8617	Length:	282	Species:	Danio rerio

Alignment Length:	228	Identity:	46/228 - (20%)
Similarity:	69/228 - (30%)	Gaps:	115/228 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 LVPLFWIPVIVKCAVEEFTTAWQDSNQLAVFSG-----------YFLFGVLLWSFLEYT---LHR 217
            ::|:..:|.:.       .|.|:      :|||           ||     ||..:.:.   |:|
Zfish   110 VMPMPPLPTVA-------PTVWE------MFSGGLGALLVFDTQYF-----LWHMVHHKNPHLYR 156

  Fly   218 WVFHVKLSNKSGSWLCTFHFMIHGLHHKV--PF---------------------DPMRLVFPPLP 259
            ||                    |.:||..  ||                     ||:.|...||
Zfish   157 WV--------------------HAIHHDYISPFSWSTQHLSGVELMTVGFWSNIDPILLKCHPL- 200

  Fly   260 GAVLAAVIYT-----------PLSFVLSHPRVILSGALAGYLCYDMMHYYLHYGNPSLWAFVHMK 313
             .|....:|:           .|.|...|  ::..|.|.|.:.:||     |:..||
Zfish   201 -TVWTLTVYSIWMSVEDHIGYDLPFSPGH--LVPFGLLGGAMAHDM-----HHQKPS-------- 249

  Fly   314 RYHHHHHFSHQTLGYGISSPLWDVVFKTRIHLR 346
             .:....|||           ||.:|.|.|.::
Zfish   250 -SNFAPFFSH-----------WDKIFGTAITVK 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	44/221 (20%)
ch25hl1.1	NP_001017865.1	ERG3	28..267	CDD:225546	45/223 (20%)
		FA_hydroxylase	131..265	CDD:282034	37/187 (20%)
		Histidine box-1	144..148		1/3 (33%)
		Histidine box-2	159..163		1/3 (33%)
		Histidine box-3	240..246		3/10 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900