DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fa2h and Ch25h

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001020586.1	Gene:	Ch25h / 309527	RGDID:	1310575	Length:	298	Species:	Rattus norvegicus

Alignment Length:	230	Identity:	47/230 - (20%)
Similarity:	78/230 - (33%)	Gaps:	58/230 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 YLEMCTKTPWWLVPLF--WIPVIVKCAVE-EFTTAWQDSNQLAVFSGYFLFGVLLWSFLEYTLHR 217
            ||..|  .|:.::.:.  |:|::.:..:. :|:.:   ..||....|..|:..|::.| ..||..
  Rat    48 YLGFC--LPFVVLDVLCPWVPILRRYKIHPDFSPS---VRQLLPCLGLTLYQHLVFVF-PVTLMH 106

  Fly   218 WVFHVKLSNKSGSWLCTF--HFMI------------HGLHHKVP--FDPMRLVFPPLPGAVLAAV 266
            |.....|..:....|...  |.:|            |.||||||  :.....|......:...|.
  Rat   107 WARSPALLPREAPELSQLLSHVLICLLLFDTEIFAWHLLHHKVPWLYRTFHKVHHQNSSSFALAT 171

  Fly   267 IYTPLSFVLS--------------HPRVILSGALAGYLCYDMMHYYL----HYGNPSLWAFVHMK 313
            .|..:..:||              ||..|        |.:.:::.:|    |.|....|:...:.
  Rat   172 QYMSVWELLSLTFFDVLNVAMLQCHPLTI--------LVFHVVNIWLSVEDHSGYDFPWSTHRLV 228

  Fly   314 RY-------HHHHHFSHQTLGYGISSPLWDVVFKT 341
            .:       ||..|.|.....:......||.:..|
  Rat   229 PFGWYGGVAHHDLHHSQFNCNFAPYFTHWDKMLGT 263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	46/228 (20%)
Ch25h	NP_001020586.1	ERG3	53..265	CDD:225546	44/223 (20%)
		FA_hydroxylase	128..263	CDD:282034	27/142 (19%)
		Histidine box-1	142..146		1/3 (33%)
		Histidine box-2	157..161		1/3 (33%)
		Histidine box-3	238..244		3/5 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900