DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fa2h and Fa2h

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001129055.1	Gene:	Fa2h / 307855	RGDID:	1310347	Length:	372	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	131/347 - (37%)
Similarity:	194/347 - (55%)	Gaps:	46/347 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YDLSRFMHKHPGGINTLKGLNSGDMTARFLKAPP--HSDAA-----MYLMREYKIDPEDSRKPKS 83
            |||:.|:..||||...|......|::|. |..||  |||.|     .|.:.|.:.||:|.
  Rat    34 YDLTGFVRHHPGGEQLLLARAGQDISAD-LDGPPHKHSDNARRWLEQYYVGELRADPQDP----- 92

  Fly    84 SQRETLHHDEDGTLRQRPRETEDKN-----NNQVDDSMEHLVDWSKAMLPQIANITDCYDEWVHK 143
                    .|:|.  ..|.||:..:     ..:|.|..:.||||.|.:|.|:.::.:.||||||:
  Rat    93 --------TENGA--GAPAETQKTDAAIEPQFKVVDWDKDLVDWQKPLLWQVGHLGEKYDEWVHQ 147

  Fly   144 PVDRPLRLFDPWYLEMCTKTPWWLVPLFWIPVIVKCAVEEFTTAWQDSNQL-------------- 194
            ||.||:|||....:|..:||.|:.||:.|:|:::..:...:.|..||:.:|
  Rat   148 PVARPIRLFHSDLIEAFSKTVWYSVPIIWVPLVLYLSWSYYRTLTQDNIRLFASFTRDYSLVVPE 212

  Fly   195 AVFSGYFLFGVLLWSFLEYTLHRWVFHVKLSNKSGSWLCTFHFMIHGLHHKVPFDPMRLVFPPLP 259
            :||.|.|:.|:|:|:.:||.:||::||:|..:.| .:|...||::||.|||.|||..||||||:|
  Rat   213 SVFIGLFVLGMLIWTLVEYLIHRFLFHMKPPSNS-HYLIMLHFVMHGQHHKAPFDGSRLVFPPVP 276

  Fly   260 GAVLAAVIYTPLSFVLSH--PRVILSGALAGYLCYDMMHYYLHYGNPSLWAFVH-MKRYHHHHHF 321
            .:|:.|..|..|..:|..  ..::.:|.|.||:.|||.|||||:|:|...:::: ||.:|..|||
  Rat   277 ASVVVAFFYVFLRLILPEAVAGILFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYNMKAHHVKHHF 341

  Fly   322 SHQTLGYGISSPLWDVVFKTRI 343
            .:|..|:|||:.|||..|.|.|
  Rat   342 EYQKSGFGISTKLWDYFFHTLI 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597	20/53 (38%)
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	99/240 (41%)
Fa2h	NP_001129055.1	Cyt-b5	12..86	CDD:395121	20/52 (38%)
Fa2h	NP_001129055.1	FA_hydroxylase	124..372	CDD:412761	100/241 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341758
Domainoid	1	1.000	143	1.000	Domainoid score	I4521
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56284
Inparanoid	1	1.050	231	1.000	Inparanoid score	I3364
OMA	1	1.010	-	-		QHG55743
OrthoDB	1	1.010	-	-		D1049908at2759
OrthoFinder	1	1.000	-	-		FOG0004076
OrthoInspector	1	1.000	-	-		oto97813
orthoMCL	1	0.900	-	-		OOG6_103477
Panther	1	1.100	-	-	LDO	PTHR12863
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2828
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770