DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fa2h and fath-1

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_492678.1	Gene:	fath-1 / 172882	WormBaseID:	WBGene00007707	Length:	316	Species:	Caenorhabditis elegans

Alignment Length:	345	Identity:	119/345 - (34%)
Similarity:	177/345 - (51%)	Gaps:	53/345 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 AESNDKFIVKYRQQYYDLSRFMHKHPGGINTLKGLNSGDMTARFLKAP--------PHSDAAMYL 67
            |:.....:|:...||||::.|..|||||...|..| :|:....|::..        .||:||..:
Worm     5 ADEKKPLLVQLDGQYYDIADFAPKHPGGAKVLNRL-AGEEIGEFIRGEKRIMGVRHEHSEAAYNM 68

  Fly    68 MREYKIDPEDSRKPKSSQRETLHHDEDGTLRQRPRETEDKNNNQVDDSMEHLVDWSKAMLPQIAN 132
            :..|.::......|                                     |::....||.::.:
Worm    69 LERYNVNAIQKGDP-------------------------------------LIESKSGMLFKVGS 96

  Fly   133 ITDCYDEWVHKPVDRPLRLFDPWYLEMCTKTPWWLVPLFWIPVIVK---CAVEEFTTAWQDSNQL 194
            :...|..|:|:|.|..|||||...||..|:|.||:||..|:|:::.   .:|..|:|:....|.:
Worm    97 LGSEYWHWIHQPYDGTLRLFDSDVLESMTRTAWWVVPAVWMPIVITFSILSVLSFSTSTDVYNSI 161

  Fly   195 AVFSGYFLFGVLLWSFLEYTLHRWVFHVKLSNKSGSWLCTFHFMIHGLHHKVPFDPMRLVFPPLP 259
            .::|.:|:.|||.|:..||:|||||||.|.|..|.:.: ..||:.||||||.|.|..||||||:|
Worm   162 LLWSAWFVIGVLTWTLTEYSLHRWVFHWKPSPDSPNQI-LLHFLAHGLHHKTPMDGDRLVFPPVP 225

  Fly   260 GAVLAAVIYTPLSFVLSHPRVILSGA--LAGYLCYDMMHYYLHYGNPSLWAFVHMKR-YHHHHHF 321
            ..::..:.|...|.....|.....||  |.||:.|||:|||||:|:|...:.:|.:: |||:|||
Worm   226 ATLIVGIFYLIYSNTFQWPVFCAFGAGKLFGYVTYDMVHYYLHHGSPRPRSNLHFRKVYHHNHHF 290

  Fly   322 SHQTLGYGISSPLWDVVFKT 341
            .:..:|:|||:.|||.||.|
Worm   291 KNFDVGFGISTSLWDYVFHT 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597	21/69 (30%)
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	96/229 (42%)
fath-1	NP_492678.1	Cyt-b5	6..72	CDD:278597	19/66 (29%)
fath-1	NP_492678.1	FA_hydroxylase	90..311	CDD:294712	96/222 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159850
Domainoid	1	1.000	144	1.000	Domainoid score	I2861
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56284
Inparanoid	1	1.050	218	1.000	Inparanoid score	I2302
Isobase	1	0.950	-	0	Normalized mean entropy	S2267
OMA	1	1.010	-	-		QHG55743
OrthoDB	1	1.010	-	-		D1049908at2759
OrthoFinder	1	1.000	-	-		FOG0004076
OrthoInspector	1	1.000	-	-		oto19138
orthoMCL	1	0.900	-	-		OOG6_103477
Panther	1	1.100	-	-	LDO	PTHR12863
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R279
SonicParanoid	1	1.000	-	-		X2828
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790