DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fa2h and Msmo1

DIOPT Version :9

Sequence 1:	NP_610279.3	Gene:	fa2h / 35670	FlyBaseID:	FBgn0050502	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_543162.1	Gene:	Msmo1 / 140910	RGDID:	620281	Length:	293	Species:	Rattus norvegicus

Alignment Length:	306	Identity:	60/306 - (19%)
Similarity:	99/306 - (32%)	Gaps:	128/306 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 VDWSKAMLPQIANITDCYDEWVHKPVDRPLRLFDPWYLEMCTK---TPW------------WLVP 169
            ||:..::||:             .|:..|.:....:.|:..||   ..|            :.:|
  Rat    17 VDYVDSLLPE-------------NPLQEPFKNAWVYMLDNYTKFQIATWGSLIVHETIYFLFSLP 68

  Fly   170 LF---WIPVIVKCAV-----EEFTTAWQDSNQLAVFSGYFLFGVLL---WSFLEY--------TL 215
            .|   :||.:.|..:     |.|...|:....: :|:.:|:...|:   :.|.|:        .:
  Rat    69 GFLFQFIPFMRKYKIQKDKPETFEGQWKCLKGI-LFNHFFIQLPLICGTYYFTEFFNIPYDWERM 132

  Fly   216 HRWVFHVKLSNKSGSWLC-----TFHFMIHG-LHHK--------------VPFDPMRLVFPPLPG 260
            .||.|  .|:...|   |     |:|:.:|. ||||              .||........||..
  Rat   133 PRWYF--TLARCLG---CAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPFGIEAEYAHPLET 192

  Fly   261 AVLAAVIYTPLSFVLSHPRVILSGALAGYLCYDMMHYYLHYGNPSLWAFVHMK------------ 313
            .:|....:..:..:..|  |||                       |||:|.|:
  Rat   193 LILGTGFFIGIVLLCDH--VIL-----------------------LWAWVTMRLLETIDVHSGYD 232

  Fly   314 ---------------RYHHHHHFSHQTLG-YGISSPLWDVVFKTRI 343
                           |:|..||.:.  :| |..:...||.:|.|.:
  Rat   233 IPLNPLNYIPFYTGARHHDFHHMNF--IGNYASTFTWWDRIFGTDV 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fa2h	NP_610279.3	Cyt-b5	6..73	CDD:278597
fa2h	NP_610279.3	FA_hydroxylase	117..341	CDD:294712	59/302 (20%)
Msmo1	NP_543162.1	FA_hydroxylase	143..274	CDD:397991	32/160 (20%)
		Histidine box-1	157..161		1/3 (33%)
		Histidine box-2	170..174		0/3 (0%)
		Histidine box-3	249..255		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3000
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900