Protein Alignment CG11125 and ENKD1

DIOPT Version :10

• Sequence 1: NP_610280.1
• Gene: CG11125 / 35669
• FlyBaseID: FBgn0033174
• Length: 388
• Species: Drosophila melanogaster
• Sequence 2: NP_115516.1
• Gene: ENKD1 / 84080
• HGNCID: 25246
• Length: 346
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 93/393 - (23%)
• Similarity: 146/393 - (37%)
• Gaps: 114/393 - (29%)

  Fly    45 KLAAKEPTRPKWMPP-LRRSSSVMGDSKAEKPAAKGKTIKQNSLQNGRSTSRSQHQLAVAVPAEG 108
            :::...|..|...|. .||.:|..|       ..:|..:|.:.|.:.|:
Human     7 RISGPIPPDPTLCPDNYRRPTSAQG-------RLEGNALKLDLLTSDRA---------------- 48

  Fly   109 ERFDGLEERNPILYDPSENLESENLQEPSSDTDIDRCQSCGTNRSSTSIAIQTEDITDELYLTNA 173
              .|....|.|.:             .|.:...::|.|     |....:.:|.|.|:  |....:
Human    49 --LDTTAPRGPCI-------------GPGAGEILERGQ-----RGVGDVLLQLEGIS--LGPGAS 91

  Fly   174 LKKCNFDARSILEESGAKYGENYKPMQYENEEDLEQ---LPLSARSNSSK----QSRFNMSEMEA 231
            ||:  .|.:...:|:..:..|..|..: |.|...||   .||.|...|.|    :||......|.
Human    92 LKR--KDPKDHEKENLRRIREIQKRFR-EQERSREQGQPRPLKALWRSPKYDKVESRVKAQLQEP 153

  Fly   232 MPMTEAEPANYGASDDEAPLSARSRFTTASNVTTISSKS------KRREHKLG-------SRDEV 283
            .|.:..|.|::        |.|.||.........:||..      :.:|..||       :|...
Human   154 GPASGTESAHF--------LRAHSRCGPGLPPPHVSSPQPTPPGPEAKEPGLGVDFIRHNARAAK 210

  Fly   284 RLPR-----------YLEKQK-------------------------REKAVAKQLAESLDPDCPR 312
            |.||           .||:|:                         |.:|.|::.::. ||..|.
Human   211 RAPRRHSCSLQVLAQVLEQQRQAQEHYNATQKGHVPHYLLERRDLWRREAEARKQSQP-DPAMPP 274

  Fly   313 GHVLLSDQDRLTHLTNAKKRYEQLVNELNHMPMTAQTLRVRNRKAEIDKELTTVEEDIRIYSKAK 377
            ||..:.:..||..||...:...||:.||..:|..|.:||.::.:||:|::|..|||.|:|:|:.|
Human   275 GHTRMPENQRLETLTKLLQSQSQLLRELVLLPAGADSLRAQSHRAELDRKLVQVEEAIKIFSRPK 339

  Fly   378 VFV 380
            |||
Human   340 VFV 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11125	NP_610280.1	Enkurin	284..375	CDD:464004	35/126 (28%)
ENKD1	NP_115516.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		7/34 (21%)
		Required for binding to microtubules. /evidence=ECO:0000269|PubMed:35197565	91..171		24/90 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	114..137		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..197		6/29 (21%)
		Enkurin	243..337	CDD:464004	29/94 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..280		7/20 (35%)