DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kappaB-Ras and nkiras2

DIOPT Version :9

Sequence 1:	NP_001137613.1	Gene:	kappaB-Ras / 35667	FlyBaseID:	FBgn0040513	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_001003433.1	Gene:	nkiras2 / 445039	ZFINID:	ZDB-GENE-040801-166	Length:	192	Species:	Danio rerio

Alignment Length:	194	Identity:	74/194 - (38%)
Similarity:	117/194 - (60%)	Gaps:	8/194 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IGKVGKVLVCGMKGVGKTALIEQLVYGHVNPETELHPTIEDIYVASVDTGRGGARETLRIYDTAG 70
            :||..||:|||...|||||::|||:|.:....:|...|:||||:.||:|.| |.||.:|.|||.|
Zfish     1 MGKSCKVVVCGQGSVGKTAVLEQLLYANHVVGSETMETLEDIYIGSVETDR-GTREQVRFYDTRG 64

  Fly    71 LQGEQQQLPRHYLQFPDAFVLVYDPMDPRSLDMLADIKADIEKHKEKKEIPVVVLANVRARAAPN 135
            |: :.|:.||||..|.|.|||||......|...:..:|.:|::.::|||:.:||:.|........
Zfish    65 LR-DGQEFPRHYFTFADGFVLVYSIDSRESFKRVEALKKEIDRCRDKKEVTIVVVGNKLDLQDQR 128

  Fly   136 PVEKVMDRANIWCQRERIKHYTVNAMERPSLYEPFTTLCARLHPMQTKSTFPQLRQVMQNRQKS 199
            .|:.  ..|..|.::|:::.:.::..:|.:|.|||..|.:::...|:|||||    :.:|:.|:
Zfish   129 RVDS--SAAQQWARQEKVRLWEISVTDRRTLIEPFVHLASKMTQPQSKSTFP----LSRNKNKT 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kappaB-Ras	NP_001137613.1	Ras	11..173	CDD:278499	63/161 (39%)
kappaB-Ras	NP_001137613.1	Ras_like_GTPase	13..174	CDD:206648	61/160 (38%)
nkiras2	NP_001003433.1	P-loop_NTPase	6..168	CDD:304359	64/165 (39%)
		small_GTPase	6..164	CDD:197466	63/161 (39%)
		Effector region	35..43		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..192		8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	126	1.000	Domainoid score	I5348
eggNOG	1	0.900	-	-		E1_KOG3883
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	139	1.000	Inparanoid score	I4490
OMA	1	1.010	-	-		QHG49065
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002909
OrthoInspector	1	1.000	-	-		otm25985
orthoMCL	1	0.900	-	-		OOG6_106084
Panther	1	1.100	-	-	O	PTHR46152
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.830