DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kappaB-Ras and Nkiras2

DIOPT Version :9

Sequence 1:	NP_001137613.1	Gene:	kappaB-Ras / 35667	FlyBaseID:	FBgn0040513	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_001099309.1	Gene:	Nkiras2 / 287707	RGDID:	1307363	Length:	191	Species:	Rattus norvegicus

Alignment Length:	189	Identity:	75/189 - (39%)
Similarity:	114/189 - (60%)	Gaps:	10/189 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IGKVGKVLVCGMKGVGKTALIEQLVYGHVNPETELHPTIEDIYVASVDTGRGGARETLRIYDTAG 70
            :||..||:|||...||||:::|||:||:....:|:..|.|||||.|::|.| |.||.:|.|||.|
  Rat     1 MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDR-GVREQVRFYDTRG 64

  Fly    71 LQGEQQQLPRHYLQFPDAFVLVYDPMDPRSLDMLADIKADIEKHKEKKEIPVVVLAN---VRARA 132
            |: :..:||:|.....|.:||||......|...:..:|.:|:|.|:|||:.:|||.|   ::.:.
  Rat    65 LR-DGAELPKHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGNKCDLQEQR 128

  Fly   133 APNPVEKVMDRANIWCQRERIKHYTVNAMERPSLYEPFTTLCARLHPMQTKSTFPQLRQ 191
            ..:|     |.|..|.:.|::|.:.|:..:|.||.|||..|.:::...|:||.||..|:
  Rat   129 RVDP-----DVAQHWAKSEKVKLWEVSVADRRSLLEPFIYLASKMTQPQSKSAFPLSRK 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kappaB-Ras	NP_001137613.1	Ras	11..173	CDD:278499	66/164 (40%)
kappaB-Ras	NP_001137613.1	Ras_like_GTPase	13..174	CDD:206648	64/163 (39%)
Nkiras2	NP_001099309.1	P-loop_NTPase	6..168	CDD:422963	67/168 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5028
eggNOG	1	0.900	-	-		E1_KOG3883
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	144	1.000	Inparanoid score	I4349
OMA	1	1.010	-	-		QHG49065
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002909
OrthoInspector	1	1.000	-	-		otm44706
orthoMCL	1	0.900	-	-		OOG6_106084
Panther	1	1.100	-	-	O	PTHR46152
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2273
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830