DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kappaB-Ras and NKIRAS1

DIOPT Version :9

Sequence 1:	NP_001137613.1	Gene:	kappaB-Ras / 35667	FlyBaseID:	FBgn0040513	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_001364280.1	Gene:	NKIRAS1 / 28512	HGNCID:	17899	Length:	192	Species:	Homo sapiens

Alignment Length:	182	Identity:	78/182 - (42%)
Similarity:	115/182 - (63%)	Gaps:	4/182 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IGKVGKVLVCGMKGVGKTALIEQLVYGHVNPETELHPTIEDIYVASVDTGRGGARETLRIYDTAG 70
            :||..||:|||:..|||||::|||:||:.....|...|:||:|:|||:|.| |.:|.|.:|||.|
Human     1 MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDR-GVKEQLHLYDTRG 64

  Fly    71 LQGEQQQLPRHYLQFPDAFVLVYDPMDPRSLDMLADIKADIEKHKEKKEIPVVVLANVRARAAPN 135
            || |..:||:||..|.|.|||||...:..|...:..:|.:|:|.|:|||:.:|||.|....:...
Human    65 LQ-EGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKIDLSEQR 128

  Fly   136 PVEKVMDRANIWCQRERIKHYTVNAMERPSLYEPFTTLCARLHPMQTKSTFP 187
            .|:  .:.|..|.:.|:::.:.|...:|.:|.||||.|.::|...|:||:||
Human   129 QVD--AEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFP 178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kappaB-Ras	NP_001137613.1	Ras	11..173	CDD:278499	69/161 (43%)
kappaB-Ras	NP_001137613.1	Ras_like_GTPase	13..174	CDD:206648	67/160 (42%)
NKIRAS1	NP_001364280.1	P-loop_NTPase	6..168	CDD:422963	70/165 (42%)
		Effector region	35..43		3/7 (43%)
		Interactions with NFKBIA and NFKBIB	58..93		18/35 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..192		6/11 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5371
eggNOG	1	0.900	-	-		E1_KOG3883
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10670
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4487
Isobase	1	0.950	-	0	Normalized mean entropy	S2119
OMA	1	1.010	-	-		QHG49065
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002909
OrthoInspector	1	1.000	-	-		otm40569
orthoMCL	1	0.900	-	-		OOG6_106084
Panther	1	1.100	-	-	LDO	PTHR46152
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2593
SonicParanoid	1	1.000	-	-		X2273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.810