DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kappaB-Ras and NKIRAS2

DIOPT Version :9

Sequence 1:	NP_001137613.1	Gene:	kappaB-Ras / 35667	FlyBaseID:	FBgn0040513	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_001001349.1	Gene:	NKIRAS2 / 28511	HGNCID:	17898	Length:	191	Species:	Homo sapiens

Alignment Length:	189	Identity:	76/189 - (40%)
Similarity:	114/189 - (60%)	Gaps:	10/189 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IGKVGKVLVCGMKGVGKTALIEQLVYGHVNPETELHPTIEDIYVASVDTGRGGARETLRIYDTAG 70
            :||..||:|||...||||:::|||:||:....:|:..|.|||||.|::|.| |.||.:|.|||.|
Human     1 MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDR-GVREQVRFYDTRG 64

  Fly    71 LQGEQQQLPRHYLQFPDAFVLVYDPMDPRSLDMLADIKADIEKHKEKKEIPVVVLAN---VRARA 132
            |: :..:||||.....|.:||||......|...:..:|.:|:|.|:|||:.:|||.|   ::.:.
Human    65 LR-DGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGNKCDLQEQR 128

  Fly   133 APNPVEKVMDRANIWCQRERIKHYTVNAMERPSLYEPFTTLCARLHPMQTKSTFPQLRQ 191
            ..:|     |.|..|.:.|::|.:.|:..:|.||.|||..|.:::...|:||.||..|:
Human   129 RVDP-----DVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPLSRK 182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kappaB-Ras	NP_001137613.1	Ras	11..173	CDD:278499	67/164 (41%)
kappaB-Ras	NP_001137613.1	Ras_like_GTPase	13..174	CDD:206648	65/163 (40%)
NKIRAS2	NP_001001349.1	Small GTPase-like	1..191		76/189 (40%)
		P-loop_NTPase	6..168	CDD:422963	68/168 (40%)
		Effector region	35..43		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..191		6/14 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5371
eggNOG	1	0.900	-	-		E1_KOG3883
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4487
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49065
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002909
OrthoInspector	1	1.000	-	-		otm40569
orthoMCL	1	0.900	-	-		OOG6_106084
Panther	1	1.100	-	-	O	PTHR46152
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.830