DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kappaB-Ras and kbrl-1

DIOPT Version :9

Sequence 1:	NP_001137613.1	Gene:	kappaB-Ras / 35667	FlyBaseID:	FBgn0040513	Length:	201	Species:	Drosophila melanogaster
Sequence 2:	NP_492076.1	Gene:	kbrl-1 / 172487	WormBaseID:	WBGene00009919	Length:	364	Species:	Caenorhabditis elegans

Alignment Length:	198	Identity:	69/198 - (34%)
Similarity:	107/198 - (54%)	Gaps:	9/198 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIGKVGKVLVCGMKGVGKTALIEQLVYGHVNPETELHPTIEDIYVASVDTGRGGARETLRIYDTA 69
            ::|:..:|:|.|.|.|||||::.|:............|||||.|...::. ...|||.|.::|||
Worm   165 RMGRAMRVVVVGGKKVGKTAILRQVACVEDVTNKPYEPTIEDTYQVLLEE-PDKAREILILHDTA 228

  Fly    70 GLQGEQQ-QLPRHYLQFPDAFVLVYDPMDPRSLDMLADIKADIEKH--KEKKEIPVVVLANVRAR 131
            |:..... :|.:.|:|..|||||||...|..|.:.:..:|..|::.  |:|||:|:|||||:|.|
Worm   229 GVSNYGPIELKKAYVQAADAFVLVYSSADYESFNRVDLLKKWIDRQFGKDKKEVPIVVLANMRDR 293

  Fly   132 AAPNPVEKVMDRANIWCQRERIKHYTVNAMERPSLYEPFTTLCARLHPMQTKSTFPQLRQVMQNR 196
              |..|:...  |:.|..||::|.:.|.|.:|.||.: |.......|...||.:...|.:.:::.
Worm   294 --PATVDSAF--AHSWAAREKVKLFEVTAKDRQSLVD-FIHYVGHRHFHPTKESKFSLSKKLKSE 353

  Fly   197 QKS 199
            :.|
Worm   354 KSS 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kappaB-Ras	NP_001137613.1	Ras	11..173	CDD:278499	63/164 (38%)
kappaB-Ras	NP_001137613.1	Ras_like_GTPase	13..174	CDD:206648	62/163 (38%)
kbrl-1	NP_492076.1	small_GTP	179..328	CDD:272973	58/154 (38%)
kbrl-1	NP_492076.1	P-loop_NTPase	183..322	CDD:304359	52/143 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167165
Domainoid	1	1.000	91	1.000	Domainoid score	I4923
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10670
Inparanoid	1	1.050	94	1.000	Inparanoid score	I3651
Isobase	1	0.950	-	0	Normalized mean entropy	S2119
OMA	1	1.010	-	-		QHG49065
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002909
OrthoInspector	1	1.000	-	-		oto19361
orthoMCL	1	0.900	-	-		OOG6_106084
Panther	1	1.100	-	-	LDO	PTHR46152
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2593
SonicParanoid	1	1.000	-	-		X2273
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.880