DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment so and six4b

DIOPT Version :9

Sequence 1:	NP_476733.1	Gene:	so / 35662	FlyBaseID:	FBgn0003460	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_571792.2	Gene:	six4b / 65232	ZFINID:	ZDB-GENE-010201-1	Length:	615	Species:	Danio rerio

Alignment Length:	312	Identity:	149/312 - (47%)
Similarity:	189/312 - (60%)	Gaps:	52/312 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SFGFTQEQVACVCEVLQQAGNIERLGRFLWSLPQCDKLQLNESVLKAKAVVAFHRGQYKELYRLL 164
            |..|:.||||||||.|.|.||::||.||||||||.|.|:.|||:|||:|:||||..:|:|||.:|
Zfish    62 SLAFSPEQVACVCEALMQGGNVDRLARFLWSLPQSDLLRGNESILKAQAIVAFHHARYQELYCIL 126

  Fly   165 EHHHFSAQNHAKLQALWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKS 229
            |:|.||..||:.||.:|.||.|.||||.||||||||.|||:|||:||||||||||||.|||||:|
Zfish   127 ENHSFSPSNHSSLQDMWYKARYTEAEKARGRPLGAVDKYRLRRKYPLPRTIWDGEETVYCFKERS 191

  Fly   230 RSVLRDWYSHNPYPSPREKRDLAEATGLTTTQVSNWFKNRRQRDRAAEHKDGSTDKQHLDSSSDS 294
            |:.|:|.|..|.||||.|||:||:.|||:.|||||||||||||||...           ::.|.|
Zfish   192 RNALKDMYKRNRYPSPAEKRNLAKMTGLSLTQVSNWFKNRRQRDRNPS-----------EAQSKS 245

  Fly   295 EMEGSMLPSQSAQHQQQQQQQQHSPGN-SSGNNNGLHQQQLQHVAAEQGLQHHPHQPHPAS---- 354
            |.:|    :.|.:.:..:.|:..||.. |||:::.:                 ||...|.:
Zfish   246 ESDG----NHSTEDESSKGQEDLSPRPLSSGSSSSV-----------------PHGTAPPTVYSD 289

  Fly   355 -------NIANVAATKSSGGG--GGGGVSAAAAAQMQMPPLTAAVAYSHLHS 397
                   .|.:|.....||||  ..|.:::..|..:.      :.||.|.||
Zfish   290 GGTTVIQQIGDVKMPSHSGGGMSYNGDLASVNAHYIN------SGAYGHSHS 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
so	NP_476733.1	SIX1_SD	103..212	CDD:293483	72/108 (67%)
so	NP_476733.1	homeodomain	223..274	CDD:238039	36/50 (72%)
six4b	NP_571792.2	SIX1_SD	65..174	CDD:293483	72/108 (67%)
		homeodomain	185..239	CDD:238039	38/53 (72%)
		E_Pc_C	<395..>478	CDD:284226
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810