Protein Alignment so and SIX2

DIOPT Version :9

• Sequence 1: NP_476733.1
• Gene: so / 35662
• FlyBaseID: FBgn0003460
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: XP_005264157.1
• Gene: SIX2 / 10736
• HGNCID: 10888
• Length: 293
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 188/332 - (56%)
• Similarity: 218/332 - (65%)
• Gaps: 61/332 - (18%)

  Fly    98 LPSFGFTQEQVACVCEVLQQAGNIERLGRFLWSLPQCDKLQLNESVLKAKAVVAFHRGQYKELYR 162
            ||:|||||||||||||||||.||||||||||||||.|:.|..||||||||||||||||.::|||:
Human     4 LPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYK 68

  Fly   163 LLEHHHFSAQNHAKLQALWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKE 227
            :||.|.||..||||||.|||||||:||||||||||||||||||||||||||:|||||||||||||
Human    69 ILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKE 133

  Fly   228 KSRSVLRDWYSHNPYPSPREKRDLAEATGLTTTQVSNWFKNRRQRDRAAEHKDG-STDKQHLDSS 291
            |||||||:||:|||||||||||:|||||||||||||||||||||||||||.|:. ..:.::.:|:
Human   134 KSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERYEENNENSNSN 198

  Fly   292 SDSEMEGS-----------MLPSQSAQHQQQQQQQQHS---PGNSSGNNNGLHQQQLQHVAAEQG 342
            |.:.:.||           ..||.:..|.........|   ||..|.::.|
Human   199 SHNPLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPGLPSLHSLG-------------- 249

  Fly   343 LQHHPHQPHPASNIANVAATKSSGGGGGGGVSAAAAAQMQMPPLTAAVAYSHLHSVMGAM--PMT 405
                 |.|.|::....|.        ||||..          ||      .|.|.:..::  ||:
Human   250 -----HPPGPSAVPVPVP--------GGGGAD----------PL------QHHHGLQDSILNPMS 285

  Fly   406 A-MYDMG 411
            | :.|:|
Human   286 ANLVDLG 292

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
so	NP_476733.1	SIX1_SD	103..212	CDD:293483	91/108 (84%)
		homeodomain	223..274	CDD:238039	47/50 (94%)
SIX2	XP_005264157.1	SIX1_SD	9..118	CDD:407119	91/108 (84%)
		homeodomain	129..180	CDD:238039	47/50 (94%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	200	1.000	Domainoid score	I3034
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2249
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001063
OrthoInspector	1	1.000	-	-		otm41377
orthoMCL	1	0.900	-	-		OOG6_106461
Panther	1	1.100	-	-	LDO	PTHR10390
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4764
SonicParanoid	1	1.000	-	-		X333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.850