Protein Alignment Eaf and EAF1

DIOPT Version :9

• Sequence 1: NP_610273.1
• Gene: Eaf / 35660
• FlyBaseID: FBgn0033166
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_149074.3
• Gene: EAF1 / 85403
• HGNCID: 20907
• Length: 268
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 123/501 - (24%)
• Similarity: 163/501 - (32%)
• Gaps: 233/501 - (46%)

  Fly     3 MTKQKNSLAERLNIGEEVRELKLGATFNPKNTSTAFHTIKYDFKPASVDTSRMASVDVGSNNQVT 67
            |....|.|.:|     |...|:||.:|. |....:||||:|||||||:|||....:.||..::||
Human     1 MNGTANPLLDR-----EEHCLRLGESFE-KRPRASFHTIRYDFKPASIDTSCEGELQVGKGDEVT 59

  Fly    68 VTVPNSESSGVPHTVYKGNQREYAKECLMIYDKETGAITIEKLNHNIQVKKTRNEVTNKSVQLPG 132
            :|:|:...|..|.||:|||:|.|.|:|::|.:.:||...:|||:.:|||||||.|.::|   :..
Human    60 ITLPHIPGSTPPMTVFKGNKRPYQKDCVLIINHDTGEYVLEKLSSSIQVKKTRAEGSSK---IQA 121

  Fly   133 QNMGQPHNQGANGAAPVAVPVPGQGSGTAPKMENSTMRISTKTKVSTGSRRNNIIDFKPRNSPMQ 197
            :...||..             |.|.|...|.......|..||..|.            |:.||::
Human   122 RMEQQPTR-------------PPQTSQPPPPPPPMPFRAPTKPPVG------------PKTSPLK 161

  Fly   198 QNSPSRPVPVHRSPQSAPAWDANNAQQTLPSIPLITDDDDFGLRAALHNSGHGNTSGTAAGQPDF 262
            .|    |.|   .||                    .||....|||
Human   162 DN----PSP---EPQ--------------------LDDIKRELRA-------------------- 179

  Fly   263 GSTSSSTHIGKQRQAPPHGHGKRQQMHQRLSPPMAQQQQPSNYGRGYNGGHNHAQQQQHHQRNSP 327
                                                                             
Human   180 ----------------------------------------------------------------- 179

  Fly   328 QQQRPSAYGHGNSMPIDVDSSREHELTSQSVAQAAAALEQQIGGALSASSSSSESDSSDSDSGSD 392
                            :||                 .:||.        ||||.|.||||:|.|.
Human   180 ----------------EVD-----------------IIEQM--------SSSSGSSSSDSESSSG 203

  Fly   393 SDDSTEDDRSTQGQQQDHQQQQQQQHQVYQNHKHTQQQVAQQHHNQLPNLGLGSISPAYGSSHQQ 457
            |||   |..|:.|:........|..|              ||.:|..|       :.|.|:|..|
Human   204 SDD---DSSSSGGEDNGPASPPQPSH--------------QQPYNSRP-------AVANGTSRPQ 244

  Fly   458 QHQQQMLPHQQKQKQQSGIYASNGGFPNDFLQNDLQLSSNSSDDDD 503
            ...|.|                      :.|:||||||.:.||.||
Human   245 GSNQLM----------------------NTLRNDLQLSESGSDSDD 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eaf	NP_610273.1	EAF	22..122	CDD:286854	49/99 (49%)
EAF1	NP_149074.3	EAF	16..114	CDD:313104	49/98 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	106..268		74/388 (19%)
		Necessary for transactivation activity	182..262		39/150 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156696
Domainoid	1	1.000	108	1.000	Domainoid score	I6439
eggNOG	1	0.900	-	-		E1_KOG4795
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4388
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002031
OrthoInspector	1	1.000	-	-		otm42017
orthoMCL	1	0.900	-	-		OOG6_107911
Panther	1	1.100	-	-	O	PTHR15970
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4334
SonicParanoid	1	1.000	-	-		X1502
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.780