Protein Alignment Eaf and Eaf2

DIOPT Version :9

• Sequence 1: NP_610273.1
• Gene: Eaf / 35660
• FlyBaseID: FBgn0033166
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_742044.1
• Gene: Eaf2 / 266787
• RGDID: 628879
• Length: 262
• Species: Rattus norvegicus
• Alignment Length: 486
• Identity: 110/486 - (22%)
• Similarity: 156/486 - (32%)
• Gaps: 241/486 - (49%)

  Fly    21 RELKLGATFNPKNTSTAFHTIKYDFKPASVDTSRMASVDVGSNNQVTVTVPNSESSGVPHTVYKG 85
            |.||||.:|. |....||||::|||||||||.|...:::||...|||:|:||.|.|..|.||:||
  Rat    15 RILKLGESFE-KQPRCAFHTVRYDFKPASVDASCEGNLEVGKGEQVTITLPNIEGSTPPVTVFKG 78

  Fly    86 NQREYAKECLMIYDKETGAITIEKLNHNIQVKKTRNEVTNK---SVQLPGQNMGQPHNQGANGAA 147
            ::|.|.|||::|.:.:||...:|||:.||.|||||.|.::|   .::...|.|..|
  Rat    79 SKRPYLKECILIINHDTGECRLEKLSSNITVKKTRGEGSSKIQCRLEQQQQQMWNP--------- 134

  Fly   148 PVAVPVPGQGSGTAPKMENSTMRISTKTKVSTGSRRNNIIDFKPRNSPMQQNSPSRPVPVHRSPQ 212
                                                       ||.|.:.|:|||
  Rat   135 -------------------------------------------PRTSNLVQHSPS---------- 146

  Fly   213 SAPAWDANNAQQTLPSIPLITDDDDFGLRAALHNSGHGNTSGTAAGQPDFGSTSSSTHIGKQRQA 277
                                                                             
  Rat   147 ----------------------------------------------------------------- 146

  Fly   278 PPHGHGKRQQMHQRLSPPMAQQQQPSNYGRGYNGGHNHAQQQQHHQRNSPQQQRPSAYGHGNSMP 342
                       ..:|||                                            .|:.
  Rat   147 -----------EDKLSP--------------------------------------------TSLM 156

  Fly   343 IDVDSSREHELTSQSVAQAAAALEQQIGGALSASSSSSESDSSDSDSGSDSDDSTEDDRSTQGQQ 407
            .|:    |.||      :|.|:|..|:....|:|.|.|.|.||..||.|||:|   ||||:...
  Rat   157 DDI----EREL------KAEASLMDQMSSCDSSSDSRSSSSSSSEDSSSDSED---DDRSSPSG- 207

  Fly   408 QDHQQQQQQQHQVYQNHKHTQQQVAQQHHNQLPNLGLGSISPAYGSSHQQQHQQQMLPHQQKQKQ 472
                                    .:::.::.|::..|   |.|.:|.......::.
  Rat   208 ------------------------PRRYSSEHPSVSAG---PQYRTSDADTTCNRLY-------- 237

  Fly   473 QSGIYASNGGFPNDFLQNDLQLSSNSSDDDD 503
                  .|.......|::|||||.:.||.:|
  Rat   238 ------DNSALLMSTLRSDLQLSESDSDSED 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eaf	NP_610273.1	EAF	22..122	CDD:286854	53/99 (54%)
Eaf2	NP_742044.1	EAF	17..113	CDD:286854	51/96 (53%)
		Necessary for interaction with ELL. /evidence=ECO:0000250	17..104		45/87 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	124..154		13/211 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..232		23/92 (25%)
		Necessary for transactivation activity. /evidence=ECO:0000250	177..262		31/129 (24%)
		Necessary for interaction with TCEA1 and transactivation activity. /evidence=ECO:0000250	248..262		7/13 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350614
Domainoid	1	1.000	108	1.000	Domainoid score	I6301
eggNOG	1	0.900	-	-		E1_KOG4795
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002031
OrthoInspector	1	1.000	-	-		otm46160
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15970
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1502
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.800