Protein Alignment Eaf and Eaf2

DIOPT Version :10

• Sequence 1: NP_610273.1
• Gene: Eaf / 35660
• FlyBaseID: FBgn0033166
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_001106872.1
• Gene: Eaf2 / 106389
• MGIID: 2146616
• Length: 262
• Species: Mus musculus
• Alignment Length: 483
• Identity: 109/483 - (22%)
• Similarity: 158/483 - (32%)
• Gaps: 235/483 - (48%)

  Fly    21 RELKLGATFNPKNTSTAFHTIKYDFKPASVDTSRMASVDVGSNNQVTVTVPNSESSGVPHTVYKG 85
            |.||||.:|. |....||||::|||||||:|||...:::||...|||:|:||.|.|..|.||:||
Mouse    15 RVLKLGESFE-KQPRCAFHTVRYDFKPASIDTSCEGNLEVGKGEQVTITLPNIEGSTPPVTVFKG 78

  Fly    86 NQREYAKECLMIYDKETGAITIEKLNHNIQVKKTRNEVTNKSVQLPGQNMGQPHNQGANGAAPVA 150
            ::|.|.|||::|.:.:||...:|||:.||.|||||.|.:::......|...|..|
Mouse    79 SKRPYLKECILIINHDTGECRLEKLSSNITVKKTRVEGSSRIQYRLEQQQQQMWN---------- 133

  Fly   151 VPVPGQGSGTAPKMENSTMRISTKTKVSTGSRRNNIIDFKPRNSPMQQNSPSRPVPVHRSPQSAP 215
                                                   .||.|.:.|:|||
Mouse   134 ---------------------------------------LPRTSNLVQHSPS------------- 146

  Fly   216 AWDANNAQQTLPSIPLITDDDDFGLRAALHNSGHGNTSGTAAGQPDFGSTSSSTHIGKQRQAPPH 280
                                                                             
Mouse   147 ----------------------------------------------------------------- 146

  Fly   281 GHGKRQQMHQRLSPPMAQQQQPSNYGRGYNGGHNHAQQQQHHQRNSPQQQRPSAYGHGNSMPIDV 345
                    .:::||                                            .|:..|:
Mouse   147 --------EEKMSP--------------------------------------------TSLMDDI 159

  Fly   346 DSSREHELTSQSVAQAAAALEQQIGGALSASSSSSESDSSDSDSGSDSDDSTEDDRSTQGQQQDH 410
                |.||      :|.|:|..|:....|:|.|.|.|.||..||.|||:|  :|..|..|
Mouse   160 ----EREL------KAEASLMDQMSSCDSSSDSKSSSSSSSEDSSSDSED--DDQFSPLG----- 207

  Fly   411 QQQQQQQHQVYQNHKHTQQQVAQQHHNQLPNLGLGSISPAYGSSHQQQHQQQMLPHQQKQKQQSG 475
                                 .:::.::.|::..|   |.|.:|.......::..|       |.
Mouse   208 ---------------------PRKYSSEHPSMSAG---PQYRTSEADATCHRLQDH-------ST 241

  Fly   476 IYASNGGFPNDFLQNDLQLSSNSSDDDD 503
            :..|.       |::|||||.:.||.:|
Mouse   242 LLMST-------LRSDLQLSESESDSED 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Eaf	NP_610273.1	EAF	23..122	CDD:462913	53/98 (54%)
Eaf2	NP_001106872.1	EAF	17..113	CDD:462913	51/96 (53%)
		Necessary for interaction with ELL. /evidence=ECO:0000250	17..104		45/87 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..237		22/97 (23%)
		Necessary for transactivation activity. /evidence=ECO:0000250	177..262		32/129 (25%)
		Necessary for interaction with TCEA1 and transactivation activity. /evidence=ECO:0000269|PubMed:12761297	248..262		7/13 (54%)