DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Y50D4B.6 and btl

DIOPT Version :9

Sequence 1:	NP_503375.2	Gene:	Y50D4B.6 / 3565593	WormBaseID:	WBGene00021745	Length:	421	Species:	Caenorhabditis elegans
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	130/427 - (30%)
Similarity:	199/427 - (46%)	Gaps:	64/427 - (14%)

- Green bases have known domain annotations that are detailed below.

Worm    11 YCIVVIALSVLFYYVWKF--YYLRKEEHEETRSLESGIIHSSSQKT----PSSVRENESLLQANE 69
            :.:..|.:..||.....|  :.||:...|:...|....:|..::|.    |..  |..|...:.:
  Fly   603 FTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGG--EEGSGCSSGD 665

Worm    70 ENVP-IGLE-------------TEPINAIIK-NLKFDERFEIDVNKFSFYNLSFLGNGYYGKVFK 119
            ..:| |.:|             |:|.....: ....|..:||...:.|..  |.||.|.:|:|.
  Fly   666 LQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLG--SILGEGAFGRVV- 727

Worm   120 ERMHKKQKNGLDSENSLE---VAVKRALRPEDPSEQQLMCEELNVMCVVGKHPNILALIRWI-RT 180
                ..:..||.....|.   ||||........::...:..|:.||.::|||.||:.|:... :.
  Fly   728 ----MAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQG 788

Worm   181 NEILIVSEFVEKGDLVEYLRARR-----------RYF-NKDIVCVEDNGRLLCPTDLLSFAFQIA 233
            ..:.::.|:...|:|.::|:..|           .|. :|.::..:..|.    .:|..||||||
  Fly   789 GPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGE----KELTKFAFQIA 849

Worm   234 NGMKFLGNVACVHRDLALRNVFVKRNRIIRIADFGLARWHENKEYYRKKTDVGFPMKWLAPECFE 298
            .||::|.:..|:|||||.|||.|....:::||||||||..::.|||||.|:...|:||:|||..
  Fly   850 RGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESL- 913

Worm   299 FEQERENIKFDSKSDIWSYGVCLYEIFSLGVSPYEGLDFRPDYF--QGLMKYVRDGNQLPSPEHG 361
              ||:   |:||:||:|||||.|:||.:.|..||      |...  :.|..|:..|.::..|...
  Fly   914 --QEK---KYDSQSDVWSYGVLLWEIMTYGDQPY------PHILSAEELYSYLITGQRMEKPAKC 967

Worm   362 SDKIYEFMQSCWNLNPDKRPVFSECRDFFQKLLQQVS 398
            |..||..|:.||:.....||.|:|..:.|..:|||.|
  Fly   968 SLNIYVVMRQCWHFESCARPTFAELVESFDGILQQAS 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Y50D4B.6	NP_503375.2	PTKc	109..391	CDD:270623	102/299 (34%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653
		Ig	507..583	CDD:299845
		PKc_like	700..1000	CDD:304357	108/322 (34%)
		TyrKc	712..996	CDD:197581	104/306 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810