DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment max-2 and Pak

DIOPT Version :9

Sequence 1:	NP_001300485.1	Gene:	max-2 / 3565400	WormBaseID:	WBGene00003144	Length:	649	Species:	Caenorhabditis elegans
Sequence 2:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	799	Identity:	281/799 - (35%)
Similarity:	397/799 - (49%)	Gaps:	189/799 - (23%)

- Green bases have known domain annotations that are detailed below.

Worm    21 PSDKD------KDRDDEMKPS--SSAMDISQPYNTVHRVHVGYDG--QKFSGLPQPWMDILLRDI 75
            |.|.|      |.:....|||  .|..:||.|.|..|.||||:|.  .:|:|:|:.|..:|:.
  Fly    55 PDDSDRKKKTLKSKIKGSKPSHTDSKPNISYPTNFEHTVHVGFDAVTGEFTGMPEAWARLLMN-- 117

Worm    76 SYFSLADQKKDPNAVVTALKFYAQSMKENEKTKFMTTNSVFTNSDDDDVDVQLTGQVTEHLRNLQ 140
            |..|..:|||:|.||:..||::..:.|:...:|:| ||::.|:|...             |..:.
  Fly   118 SNISKQEQKKNPQAVLDVLKWFDNTTKQRPSSKYM-TNAITTHSGSS-------------LSRVS 168

Worm   141 CSNGSATSPSTSVSASSSSARPL----------TNGNN-----------------HL-------- 170
            .|:.|:|...:.:..|:|....:          .|.||                 ||
  Fly   169 SSSPSSTPTDSELHGSNSGGNLIGVQLGSMTLGPNANNVAVAGQILGNHYQQQQQHLLQQQQPLL 233

Worm   171 ----------------------STASSTDTSLSLSE------RNNVPSPAPVPYSESAPQLKT-F 206
                                  :.:|||....|.:|      ::....|.|.|.:....:.|: :
  Fly   234 HQNHNQHHMGISQSHSYNFVGHTVSSSTSQHSSANEDDMLGPQHPQQQPPPPPVASRPERTKSIY 298

Worm   207 TGETPKLHPR-SPFPPQPPVLP----QRSKTASAVATTTTNPTTSNGAPPPVPGSKGPPVPPKPS 266
            |.....|.|. .|.|..|...|    |..:|...::....:|...|.|...:..:|....|..|:
  Fly   299 TRPIEDLQPAIIPMPVAPATTPATPLQNHRTPGGISAPAASPMMHNNATTTLDKNKNNATPTSPT 363

Worm   267 HLKI--------ASSTVSSGCSSPQQYSSARSVGNSLSNGSVVST-----TSSDGDVQLSNKEN- 317
            ..|.        |:||:.|..:.....:.......:...||:|.|     |::...|..|...|
  Fly   364 TTKTTAETEGTDATSTLLSATNPSCSTTPTTDPAPAAPRGSLVETATAHATTAAATVATSTTTNH 428

Worm   318 -------SNDKSVGDKNG------------------NTTTNKTTVEPPPP--------------- 342
                   |:..|..|.:|                  |:|.:.....|.||
  Fly   429 HSSASSFSSFPSFHDDDGTHHALPTIHCPTPTSSSRNSTVSFPVAVPLPPIVTPASPTPASIESP 493

Worm   343 ----EEPPV--------------------------------RVRASHREKLSDSEVLNQLREIVN 371
                .||.|                                |...:.::|:||.|:|.:||.||:
  Fly   494 DLYTPEPTVAQVSAGGPSSQVAGNQIAVPQAAVAPAATPNTRAANAKKKKMSDEEILEKLRTIVS 558

Worm   372 PSNPLGKYEMKKQIGVGASGTVFVANVAGSTDV-VAVKRMAFKTQPKKEMLLTEIKVMKQYRHPN 435
            ..:|..||...::||.||||||:.| :..||.: ||:|:|....|||||:::.||.||::.:|||
  Fly   559 VGDPNRKYTKMEKIGQGASGTVYTA-IESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPN 622

Worm   436 LVNYIESYLVDADDLWVVMDYLEGGNLTDVVVKTELDEGQIAAVLQECLKALHFLHRHSIVHRDI 500
            :|||::|||| :::|||||:||.||:|||||.:|.:||||||||.:|.|:||.|||.:.::||||
  Fly   623 VVNYLDSYLV-SEELWVVMEYLPGGSLTDVVTETCMDEGQIAAVCREVLQALEFLHANQVIHRDI 686

Worm   501 KSDNVLLGMNGEVKLTDMGFCAQIQP-GSKRDTVVGTPYWMSPEILNKKQYNYKVDIWSLGIMAL 564
            ||||:|||::|.|||||.||||||.| .|||.|:|||||||:||::.:|||..|||:|||||||:
  Fly   687 KSDNILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQYGPKVDLWSLGIMAI 751

Worm   565 EMIDGEPPYLRETPLKAIYLIAQNGKPEIKQRDRLSSEFNNFLDKCLVVDPDQRADTTELLAHPF 629
            ||::||||||.|.||||:||||.|||||||::|:|||.|.:|||:||.|:.|:||...:||.|||
  Fly   752 EMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPF 816

Worm   630 LKKAKPLSSLIPYIRAVRE 648
            ||.|:||:||.|.|.|.:|
  Fly   817 LKLARPLASLTPLIMAAKE 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
max-2	NP_001300485.1	STKc_PAK	378..631	CDD:270789	159/254 (63%)
max-2	NP_001300485.1	S_TKc	379..630	CDD:214567	157/252 (62%)
Pak	NP_001138013.2	PBD	83..137	CDD:279166	23/55 (42%)
		STKc_PAK_I	558..818	CDD:270814	160/261 (61%)
		S_TKc	566..817	CDD:214567	157/252 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425477at33208
OrthoFinder	1	1.000	-	-		FOG0000763
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100484
Panther	1	1.100	-	-	O	PTHR48015
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920