DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and DHX38

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_054722.2	Gene:	DHX38 / 9785	HGNCID:	17211	Length:	1227	Species:	Homo sapiens

Alignment Length:	736	Identity:	314/736 - (42%)
Similarity:	468/736 - (63%)	Gaps:	43/736 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EVGETYGSKAKKDPEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIA 71
            ::|:..|.|.:::|:.:.:..........|.....:..|..      .::.:::: :::.::|..
Human   474 KLGDIMGVKKEEEPDKAVTEDGKVDYRTEQKFADHMKRKSE------ASSEFAKK-KSILEQRQY 531

  Fly    72 LPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWC-----VDFAVSKGRKGVSCTQPRRVAA 131
            ||:|..|.:.:.::..:..:::|||||||||||:.|:.     .|:.:      :.|||||||||
Human   532 LPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHEDGYTDYGM------IGCTQPRRVAA 590

  Fly   132 MSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAH 196
            ||||:||||||...|||||||:||||||::..||:||||||:||||::.:..||.|..|::||||
Human   591 MSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENTLIKYMTDGILLRESLREADLDHYSAIIMDEAH 655

  Fly   197 ERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPE 261
            ||:|.||:|.|:|:||:.:||||||:|.|||:||.||..:|.|.|:..:||||.||:|.::..|:
Human   656 ERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQ 720

  Fly   262 RDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLP 326
            .||:|||::..:|:|: ....||||:|:.|||:||....:|...::.| .....|..:|:||.||
Human   721 EDYVEAAVKQSLQVHL-SGAPGDILIFMPGQEDIEVTSDQIVEHLEEL-ENAPALAVLPIYSQLP 783

  Fly   327 PNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLV 391
            .:||.:||:.||    :|.  ||.:|:|||||||||:||::||||.|:.|.||:||||.:::|.:
Human   784 SDLQAKIFQKAP----DGV--RKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQI 842

  Fly   392 SPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLV 456
            .|||:|:|.|||||||||.||:||||||:.|:|||:...|.|||.|:||..|||.||.||:.||:
Human   843 YPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLL 907

  Fly   457 HFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEIL 521
            .|.|||||..:.::.::..|..|.|||:.|.||..|.:|.||||||.|:||||.||...||:|||
Human   908 QFHFMDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEIL 972

  Fly   522 SITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFINFRS 586
            .|.:|||||..|.||...::.:|:.:.:||..:.||||.||||..:|.::....||.::||:.::
Human   973 LIVSMLSVPAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKA 1037

  Fly   587 LKSADNVRQQLARIM--DRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDN 649
            ::....||.||..||  .|.:|....|::..      :||.:...:|.|.|.|:..|.|:.|:..
Human  1038 MRKVREVRAQLKDIMVQQRMSLASCGTDWDI------VRKCICAAYFHQAAKLKGIGEYVNIRTG 1096

  Fly   650 QNVQLHPSTCL---DHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDLNNFPQC---- 707
            ....|||::.|   .:.||:::|:|.|:|||.|::.||.|..|||..|.|.:|.:....:.
Human  1097 MPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAELGPMFYSVKQAGKSRQEN 1161

  Fly   708 --EAKRQLELLQQRLETKQYQ 726
              .||.:...:::.:...:.|
Human  1162 RRRAKEEASAMEEEMALAEEQ 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	12/51 (24%)
		DEXDc	67..255	CDD:214692	103/192 (54%)
		DEXDc	91..228	CDD:238005	84/141 (60%)
		HELICc	315..408	CDD:197757	51/92 (55%)
		HA2	478..561	CDD:214852	43/82 (52%)
		OB_NTP_bind	595..698	CDD:285018	37/107 (35%)
DHX38	NP_054722.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..320
		HrpA	515..1146	CDD:224557	303/651 (47%)
		DEAH box	652..655		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1155..1227		3/28 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720