DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dhx15 and DHX57

DIOPT Version :9

Sequence 1:NP_001260766.1 Gene:Dhx15 / 35654 FlyBaseID:FBgn0033160 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_945314.1 Gene:DHX57 / 90957 HGNCID:20086 Length:1386 Species:Homo sapiens


Alignment Length:787 Identity:222/787 - (28%)
Similarity:380/787 - (48%) Gaps:170/787 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 SQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVS- 122
            |:::|::.::|.:||.:|.:...:.||..||.:|:.|.||.||||||||:.:|.:::...:.|: 
Human   531 SRQFQSILQERQSLPAWEERETILNLLRKHQVVVISGMTGCGKTTQIPQFILDDSLNGPPEKVAN 595

  Fly   123 --CTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLD 185
              ||||||::|:|||:||::|...::|..|||.||.|...::.|.|.|.|.|:|||....|..|.
Human   596 IICTQPRRISAISVAERVAKERAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQ 660

  Fly   186 QYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTH 250
            ....|::||.||||..:|.|:.|||:::.||..|::::|||||:|..|..||::.|::.:||||.
Human   661 GVSHIIVDEVHERTEESDFLLLVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITIPGRTF 725

  Fly   251 PVEIFY----------------------------------------------------------- 256
            ||:.|:                                                           
Human   726 PVDQFFLEDAIAVTRYVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQDQDSVK 790

  Fly   257 --TPEPERDYLE----------AAIRTV-------IQIHMCEEI------------EGDILMFLT 290
              .|:.:.|:.:          :.|:|:       :.:.:.|.:            .|.||:||.
Human   791 DAVPDQQLDFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLP 855

  Fly   291 GQEEIEEACKRIKREIDNLGSEIGELKCI--PLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVS 353
            |..||:...:::  :.::|.:.....:|:  ||:|:|....||.:| ..||....     |:::|
Human   856 GLAEIKMLYEQL--QSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVF-VKPPAGVT-----KIIIS 912

  Fly   354 TNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLY 418
            |||||||:|||.||:|||.|..|:|.|:....:|||..:.:|:|:|.||.|||||...|.||.|:
Human   913 TNIAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLF 977

  Fly   419 TEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDL-----VHFDFMDPPAPETLMRALELLNY 478
            |...:.:::.....|||.|..|..:.|::|.|.:...     |....::||..::|..:...|..
Human   978 TSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRLRD 1042

  Fly   479 LAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAA 543
            |.||..|..||.||..::..|:|.::.|:::......|.:..|:|.|.|:....||.|.:.|:.|
Human  1043 LGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEA 1107

  Fly   544 DEAKMRFAHIDGDHLTLLNVYHAFKQSSEDP-----NWCYENFINFRSLKSADNVRQQLARIMDR 603
            ::.|:.||..:.|:|.||..|..::.|:::.     |:|.:||::.|.|:...::::|...::..
Human  1108 NQKKLEFAFANSDYLALLQAYKGWQLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFTELLSD 1172

  Fly   604 FNLRR---------------------TSTEFTSKDYYVNIRKALV--------------QGFFMQ 633
            ....|                     |..|..|......:..|::              :|.|.:
Human  1173 IGFAREGLRAREIEKRAQGGDGVLDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQK 1237

  Fly   634 VAHLERTG-----------YYLTIKDNQNVQLHPSTC---LDH-KPDWVIYNEFVLTTKNYIR-- 681
            .:    ||           .::| |::..|.:|||:.   :.| ...:::|:|.:.|::.:||  
Human  1238 TS----TGAVRMQPKSAELKFVT-KNDGYVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDC 1297

  Fly   682 TVTDVKP 688
            ::..|.|
Human  1298 SMVSVYP 1304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dhx15NP_001260766.1 Motor_domain 50..>102 CDD:277568 15/42 (36%)
DEXDc 67..255 CDD:214692 83/190 (44%)
DEXDc 91..228 CDD:238005 62/139 (45%)
HELICc 315..408 CDD:197757 42/94 (45%)
HA2 478..561 CDD:214852 26/82 (32%)
OB_NTP_bind 595..698 CDD:285018 24/146 (16%)
DHX57NP_945314.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..106
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..147
UBA_DHX57 181..218 CDD:270502
RWD 243..418 CDD:283440
ZnF_C3H1 303..323 CDD:214632
DEXDc 550..730 CDD:214692 79/179 (44%)
DEXDc 561..703 CDD:238005 63/141 (45%)
DEVH box 668..671 2/2 (100%)
Helicase_C 832..968 CDD:278689 53/143 (37%)
HA2 1043..1125 CDD:214852 26/81 (32%)
OB_NTP_bind 1164..1310 CDD:285018 24/146 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.