DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and PRP22

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_010929.3	Gene:	PRP22 / 856732	SGDID:	S000000815	Length:	1145	Species:	Saccharomyces cerevisiae

Alignment Length:	665	Identity:	316/665 - (47%)
Similarity:	448/665 - (67%)	Gaps:	23/665 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 TNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSK-G 117
            |:.|.|.:.|       .|||:..:::.::.:..:|.:|:||||||||||||.|:..:...|. |
Yeast   472 TSLPISAQRQ-------TLPVYAMRSELIQAVRDNQFLVIVGETGSGKTTQITQYLDEEGFSNYG 529

  Fly   118 RKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDP 182
            .  :.|||||||||:|||:||:||:..|:|.:|||:|||||.:...|.:||||||||.|||:.||
Yeast   530 M--IGCTQPRRVAAVSVAKRVAEEVGCKVGHDVGYTIRFEDVTGPDTRIKYMTDGMLQREALLDP 592

  Fly   183 MLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPG 247
            .:.:|.||:||||||||:|||:|..:||:...:|.:||::|.||||::.||.:||.|.|::.:||
Yeast   593 EMSKYSVIMLDEAHERTVATDVLFALLKKAAIKRPELKVIVTSATLNSAKFSEYFLNCPIINIPG 657

  Fly   248 RTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSE 312
            :|.|||:.|:..|:.||:|||:..||.||: .|..||||:||||||||:..|:.:...:..||..
Yeast   658 KTFPVEVLYSQTPQMDYIEAALDCVIDIHI-NEGPGDILVFLTGQEEIDSCCEILYDRVKTLGDS 721

  Fly   313 IGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQ 377
            ||||..:|:||.||..:|.:||||.|..:      ||||.:|||||||:||||:.:|:||||||.
Yeast   722 IGELLILPVYSALPSEIQSKIFEPTPKGS------RKVVFATNIAETSITIDGIYYVVDPGFAKI 780

  Fly   378 KVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGT 442
            .:||.|..:|.|:|||||:|.|.||.||||||.||||:|||||.||.|||.:||.|||.|.||..
Yeast   781 NIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEMLENTVPEIQRQNLSH 845

  Fly   443 VVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKM 507
            .:|.||.:||:||:.|||||||....::.||..|.:|.:|||:|.||:||..||.||:||.|::.
Yeast   846 TILMLKAMGINDLLKFDFMDPPPKNLMLNALTELYHLQSLDDEGKLTNLGKEMSLFPMDPTLSRS 910

  Fly   508 LIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSE 572
            |::|..:.||:||::|.:||||...|.||.:.:..||..|.:|.|..||||||||||..::|::.
Yeast   911 LLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSKKAKFHHPYGDHLTLLNVYTRWQQANY 975

  Fly   573 DPNWCYENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHL 637
            ...:|..||::||.||.|.:|:.|::.|..:..|:..|.. :..|.   |||..|.||||..|..
Yeast   976 SEQYCKTNFLHFRHLKRARDVKSQISMIFKKIGLKLISCH-SDPDL---IRKTFVSGFFMNAAKR 1036

  Fly   638 ERTGYYLTIKDNQNVQLHPSTCLDHKP-DWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDL 701
            :....|.||.....|.:|||:.|..|. ::|:|:..|||::.|:..||.::|:||..:||.:|..
Yeast  1037 DSQVGYKTINGGTEVGIHPSSSLYGKEYEYVMYHSIVLTSREYMSQVTSIEPQWLLEVAPHFYKA 1101

  Fly   702 NNFPQCEAKRQLELL 716
            .: .:.:::::.:::
Yeast  1102 GD-AESQSRKKAKII 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	16/47 (34%)
		DEXDc	67..255	CDD:214692	97/188 (52%)
		DEXDc	91..228	CDD:238005	79/137 (58%)
		HELICc	315..408	CDD:197757	52/92 (57%)
		HA2	478..561	CDD:214852	40/82 (49%)
		OB_NTP_bind	595..698	CDD:285018	36/103 (35%)
PRP22	NP_010929.3	Pnp	1..423	CDD:224106
PRP22	NP_010929.3	HrpA	456..1145	CDD:224557	316/665 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
TreeFam	0	0.000	Not matched by this tool.
	6	5.720