DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and ECM16

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_013847.1	Gene:	ECM16 / 855158	SGDID:	S000004735	Length:	1267	Species:	Saccharomyces cerevisiae

Alignment Length:	894	Identity:	260/894 - (29%)
Similarity:	400/894 - (44%)	Gaps:	242/894 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVS-------KGR 118
            |...:.|.||.||||..:...|..:..:..:::.||||||||||:||:..:....       .|.
Yeast   380 RSDEIQKARIQLPVFGEEHKIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGFGAEDSPDYPGM 444

  Fly   119 KGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPM 183
            .|:  ||||||||:|:|:||:.|:. ..|.:|||.|||:..:...|.:|:||||:||||.|.|..
Yeast   445 VGI--TQPRRVAAVSMAERVANELG-DHGHKVGYQIRFDSTAKEDTKVKFMTDGVLLREMMHDFK 506

  Fly   184 LDQYQVILLDEAHERTLATDILMGVLKEVIRQRS-----------DLKLVVMSATLDAGKFQQ-- 235
            |.:|..|::||||||.:.||||:|:|...:|.|:           .|||::|||||....|.:
Yeast   507 LTKYSSIIIDEAHERNINTDILIGMLSRCVRLRAKLHKENPIEHKKLKLIIMSATLRVSDFSENK 571

  Fly   236 -YFDNA-PLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEA 298
             .|..| |:::|..|..||.|.:......:|.:.|.|...:||. :...|.||:|||||:||...
Yeast   572 TLFPIAPPVLQVDARQFPVSIHFNRRTAFNYTDEAFRKTCKIHQ-KLPPGAILVFLTGQQEITHM 635

  Fly   299 CKRIKREI------------------------------------------DNLGSEI-------- 313
            .||:::|.                                          |...|.|
Yeast   636 VKRLRKEFPFKKNSKYNKDLETPVSKMGINSKTTDLEAEDIDFSVQVIDQDKFKSAIRYEEDEGN 700

  Fly   314 ---GE-----------------------LKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVV 352
               ||                       |..:||||.||...|.|:|:  .||..:    |..:|
Yeast   701 SGNGEDEEDEEEEGFEEVLTEGQTANDPLYVLPLYSLLPTKEQMRVFQ--KPPQGS----RLCIV 759

  Fly   353 STNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRL 417
            :||:|||||||.||.:|:|.|.:|::.||....|:|..|..:|||||.|||||||||.||.|:||
Yeast   760 ATNVAETSLTIPGVRYVVDSGRSKERKYNESNGVQSFEVGWVSKASANQRSGRAGRTGPGHCYRL 824

  Fly   418 YTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAAL 482
            |:...|:::.:..:.|||||..:.::|||:|.:.|.::::|.|..||....|.:|::||.||.||
Yeast   825 YSSAVFEHDFEQFSKPEILRMPVESIVLQMKSMAIHNIINFPFPTPPDRVALSKAIQLLQYLGAL 889

  Fly   483 DDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFV------------R 535
            |:...:|:.|..||.|||.|:.:|||:.|.:..|...|::|.:.|||...|:            :
Yeast   890 DNKEMITEDGKKMSLFPLSPRFSKMLLVSDEKACLPYIVAIVSALSVGDPFINEFELGINEISRK 954

  Fly   536 PNEAKKAAD-------------------------EAKMRFAHID--GDHLTLLNVYHAFKQSSED 573
            ||..:...|                         :::.:|:.:|  .|...||:|..|.....::
Yeast   955 PNPDENLDDKIREHDESTPGMDPELKKELRSKFYKSRSQFSKLDKFSDVFRLLSVVSAMDYVPKE 1019

  Fly   574 PNWCY--ENFINFRSLKSADNVRQQLARIMDRFNLRRTSTE-----FTSKDYYVNI--------- 622
            ....:  :||:..:.::....:|:||..|:.    ..||.|     ..::|...:|
Yeast  1020 QKEIFMKKNFLRGKLMEEIVKLRKQLMYIIK----SNTSKENIAVVIRNEDLKSDIPSVIQIKLL 1080

  Fly   623 RKALVQGFFMQVA------------HLERTGY----YLTIKDNQN-------VQLHPSTCLDH-- 662
            ::.:..||...||            ...||..    |:.:...:.       |.:||::.|::
Yeast  1081 KQMICAGFVDHVAVRADVLFPDDAKITNRTSIINIPYIPVLATRTPNIEDCFVYIHPTSILNNLG 1145

  Fly   663 --KPDWVIYNEFVL--TTKNYIRTVTDV------------------KP--------------EWL 691
              .|.:::|....|  ..|..:.|:.|:                  ||              |..
Yeast  1146 EMPPKYMLYYSLHLGGNNKTRMNTLCDIASTPLANIARKGLLLTYSKPLTGQGLKTVNLSPTERY 1210

  Fly   692 CCLAPQY-----------YDLNNFPQCEAKRQLELLQQRLETKQYQKGF 729
            |.:.|::           :|||.....:.|::.:....:..|:   |||
Yeast  1211 CYVVPRFGSTVDNDLKIGWDLNPIAVHQKKQKGQWTVIKFITR---KGF 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	15/40 (38%)
		DEXDc	67..255	CDD:214692	87/209 (42%)
		DEXDc	91..228	CDD:238005	69/154 (45%)
		HELICc	315..408	CDD:197757	46/115 (40%)
		HA2	478..561	CDD:214852	30/121 (25%)
		OB_NTP_bind	595..698	CDD:285018	30/177 (17%)
ECM16	NP_013847.1	HrpA	360..1267	CDD:224557	260/894 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810