DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and DHX16

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_003578.2	Gene:	DHX16 / 8449	HGNCID:	2739	Length:	1041	Species:	Homo sapiens

Alignment Length:	679	Identity:	345/679 - (50%)
Similarity:	477/679 - (70%)	Gaps:	23/679 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 QILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSG 100
            |:.|...|: .|||      :..:|:.:::...|.:||||.::.:.:..::.||.:::.||||||
Human   370 QLQGDEEPS-APPT------STQAQQKESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSG 427

  Fly   101 KTTQIPQWCVDFA-VSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKT 164
            |||||||:..:.. .:||.| ::|||||||||||||.||:.||.||||.|||||||||||::.:|
Human   428 KTTQIPQYLFEEGYTNKGMK-IACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERT 491

  Fly   165 LLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLD 229
            :|:||||||||||.:|:|.|..|.|:::||||||||.||||.|::|:|.|.|.:||::|.|||:|
Human   492 VLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMD 556

  Fly   230 AGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEE 294
            ..:|..:||:||:.::|||..||:||||..||.|||||.:.:|:|||:.:. .||||:|||||||
Human   557 TARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQP-PGDILVFLTGQEE 620

  Fly   295 IEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAET 359
            ||.||:.::.....|||:|.||..:|:|:.||.::|.|||:|.||    ||  |||||:||||||
Human   621 IEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPP----GA--RKVVVATNIAET 679

  Fly   360 SLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFK 424
            ||||:|:::|:||||.|||.||||..:|||.|:|.|||||.||:|||||...||||||||..|::
Human   680 SLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQ 744

  Fly   425 NEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLT 489
            :|:::.|.|||.|::||.|||.||.|||.||:||||:|||..|||:.|||.|..|.||:..|.||
Human   745 HELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELT 809

  Fly   490 DLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSV-PQCFVRPNEAKKAADEAKMRFAHI 553
            ..|..|:|.|:||.|:||::||.:::||.|||::.||||| ...|.||.:....||.|::.|...
Human   810 TSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLP 874

  Fly   554 DGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDY 618
            .||||.|||||..:.:|.....||||||:.|||::.|.:||:||..:::|..:..:|.:    ..
Human   875 GGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQ----GD 935

  Fly   619 YVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCL-DHKPDWVIYNEFVLTTKNYIRT 682
            |:.:|||:..|:|...|.|.|:| |.|:|..|.|.:||::.| :.:|.|::|:|.|||||.::|.
Human   936 YIRVRKAITAGYFYHTARLTRSG-YRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQ 999

  Fly   683 VTDVKPEWLCCLAPQYYDLNNFPQCEAKR 711
            |.:::..||..:||.||.........||:
Human  1000 VLEIESSWLLEVAPHYYKAKELEDPHAKK 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	14/51 (27%)
		DEXDc	67..255	CDD:214692	106/188 (56%)
		DEXDc	91..228	CDD:238005	87/137 (64%)
		HELICc	315..408	CDD:197757	58/92 (63%)
		HA2	478..561	CDD:214852	38/83 (46%)
		OB_NTP_bind	595..698	CDD:285018	37/103 (36%)
DHX16	NP_003578.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..207
		PTZ00121	<148..376	CDD:173412	2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	371..391		6/26 (23%)
		HrpA	390..1028	CDD:224557	337/650 (52%)
		DEAH box	520..523		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730