DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and DHX40

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_078888.4	Gene:	DHX40 / 79665	HGNCID:	18018	Length:	779	Species:	Homo sapiens

Alignment Length:	720	Identity:	272/720 - (37%)
Similarity:	413/720 - (57%)	Gaps:	78/720 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIA-------------------LPVFEYQADFMR 83
            :.|..|.:|..          .:|.::|.::|::                   .|.|..|....:
Human     7 VAGRAPRRQEE----------GERSRDLQEERLSAVCIADREEKGCTSQEGGTTPTFPIQKQRKK 61

  Fly    84 LLSL---HQCIVLVGETGSGKTTQIPQWCVDFAVSK-GRKGVSCTQPRRVAAMSVAQRVSEEMDV 144
            ::..   :..:::.|.||||||||:|::..:...|: |..||  ||||:|||:||||||:|||..
Human    62 IIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGV--TQPRKVAAISVAQRVAEEMKC 124

  Fly   145 KLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVL 209
            .||.:|||.:||:|||:.:|.:||||||.||:..:.||.|.::.||:|||||||||.||||.|:|
Human   125 TLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTLTTDILFGLL 189

  Fly   210 KEVIRQRS-----DLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPV-EIFYTPEPERD----- 263
            |::.:::|     .||:||||||::..|...:|.|.|:..:|||.:|| |.|......||
Human   190 KKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTA 254

  Fly   264 YLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEAC-------KRIKREIDNLGSEIGELKCIPL 321
            |::|.::..:.||: .|:.||||:|||||.|||::|       :.:..:.|...:.:..|..:|.
Human   255 YIQAIVKVTMDIHL-NEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPC 318

  Fly   322 YSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRV 386
            |.::..:.|:|||.| |||..     ||.|:||||:.|||||||:.:|:|.||.||..:|||:.:
Human   319 YGSMTTDQQRRIFLP-PPPGI-----RKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGL 377

  Fly   387 ESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLG 451
            :.|.|.||||:.|.|||||||||..|||||:|::..:...|.|:..|||.|::|.:|||.||.|.
Human   378 DILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLA 442

  Fly   452 IDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNC 516
            |.|::.|.::|||....::.||:.|....|:|..|::|.||..|.||||.|.|...:|.:...:|
Human   443 IHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDC 507

  Fly   517 SNEILSITAMLSVPQCFVRP--NEAKKAADEAKMRFAHIDG---DHLTLLNVYHAFKQSSEDPNW 576
            .:.:|.|.|||||...|:||  .|.:|.|::.....|...|   |..||..::...|.|....:|
Human   508 EDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASW 572

  Fly   577 CYENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDY----YVNIRKALVQGFFMQVAHL 637
            |.:::|::|.|.||..|..||..::.:.   :..::|..:.:    :..:|:.|..|:|..||.
Human   573 CQKHWIHWRCLFSAFRVEAQLRELIRKL---KQQSDFPKETFEGPKHEVLRRCLCAGYFKNVAR- 633

  Fly   638 ERTGYYLTIKDNQN--VQLHPSTCL---DHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQ 697
            ...|......|.:.  |.:|||:.|   :.|.:|:|::|.::|||.|.|.|..::.||:..|.|:
Human   634 RSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPK 698

  Fly   698 YYDLN 702
            .::.|
Human   699 LHEFN 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	11/73 (15%)
		DEXDc	67..255	CDD:214692	93/216 (43%)
		DEXDc	91..228	CDD:238005	78/142 (55%)
		HELICc	315..408	CDD:197757	47/92 (51%)
		HA2	478..561	CDD:214852	32/87 (37%)
		OB_NTP_bind	595..698	CDD:285018	30/111 (27%)
DHX40	NP_078888.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28		5/30 (17%)
		HrpA	16..770	CDD:224557	269/711 (38%)
		DEAH box	173..176		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..779
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820