DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and dhx33

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001093527.3	Gene:	dhx33 / 796505	ZFINID:	ZDB-GENE-131127-77	Length:	680	Species:	Danio rerio

Alignment Length:	707	Identity:	302/707 - (42%)
Similarity:	435/707 - (61%)	Gaps:	57/707 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RRIEVGETYGSKAKKDPEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKK 68
            :|.:.|..:....||.......:..||||..||                       :|:..:|:.
Zfish    11 KRFKPGSPFFRLDKKPGMLLPRAGHAAAGVEAQ-----------------------RRHLPIYQS 52

  Fly    69 RIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKG-VSCTQPRRVAAM 132
            |..:        ..:|..||.. |.:|||||||||||||:..:..:  ||:| ::.||||||||:
Zfish    53 RTQV--------ISQLRQLHSA-VFIGETGSGKTTQIPQYLYEAGI--GRQGIIAITQPRRVAAI 106

  Fly   133 SVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHE 197
            |:|.||:||..|:||:.|||::||||.::.:|.||:||||||||||:.||:|.:|.|::||||||
Zfish   107 SLAGRVAEEKKVQLGKLVGYTVRFEDVTSPETKLKFMTDGMLLREAIGDPLLLRYTVVILDEAHE 171

  Fly   198 RTLATDILMGVLKEVIRQRSD-----LKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYT 257
            ||:.||:|.||:|...|:|.:     ||:||||||:|...|.|||:.:|::.:.||.||::|:||
Zfish   172 RTVHTDVLFGVVKAAQRRRLEQNKIPLKVVVMSATMDVDLFSQYFNKSPVLYLEGRQHPIQIYYT 236

  Fly   258 PEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREID-NLGSEIGELKCIPL 321
            .:|:.|||:||:.::.|||.......|||:|||||||| ||..|..|:|. :|....|.:..:||
Zfish   237 KQPQSDYLQAALVSIFQIHQEAPSSHDILVFLTGQEEI-EALARTCRDISKHLPDTSGSMTVVPL 300

  Fly   322 YSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRV 386
            |::|||..|.|:|.|||..:      |||::||||||||:||.|:.:|||.|..|.|.:||...:
Zfish   301 YASLPPAQQMRVFLPAPKGS------RKVILSTNIAETSITISGIKYVIDTGMVKAKRFNPDSGL 359

  Fly   387 ESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLG 451
            |.|.|..:|||.|.||:|||||...|.|:|||||..|:| :.:.|.|||.|.||.:|||||..||
Zfish   360 EVLAVQRVSKAQAWQRAGRAGREDAGSCYRLYTEDEFEN-LANMTVPEIQRCNLASVVLQLLALG 423

  Fly   452 IDDLVHFDFMDPPAPETLMRALELLNYLAAL---DDDGNLTDLGAVMSEFPLDPQLAKMLIASCQ 513
            :.|:::|||:..|:||::..|:|.|..|.|:   ||..:||.||..|:.|||:|:.:|.|:.|..
Zfish   424 VPDVLNFDFVSKPSPESMRTAVEQLCILGAVDRKDDHVSLTPLGKKMACFPLEPRFSKTLLISPD 488

  Fly   514 HNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCY 578
            .:|:.|||:|.::|||......|...:......:.:|...:|||:||||:|.|||:.|.:.:||.
Zfish   489 FSCTEEILTIISLLSVDSVLYNPPARRDEVISVRKKFISSEGDHITLLNIYRAFKKVSGNKDWCR 553

  Fly   579 ENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYY 643
            |||:|.|::.....||.||..|..:.||:..|    |.....|:|:.|..|.||..|.|:..|.|
Zfish   554 ENFVNSRNMGLVGEVRAQLRDICIKMNLKLES----SVCDLANVRRCLAHGLFMSAAELQPDGSY 614

  Fly   644 LTIKDNQNVQLHPSTCL-DHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYY 699
            :.:..:|.|.:|||:.| ..:|..|::||.:.|::.|:|.:..::.:||...||:|:
Zfish   615 VALDTHQPVSIHPSSVLFQARPVCVLFNELLHTSRCYMRDLCLIQTDWLHEAAPEYF 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	13/51 (25%)
		DEXDc	67..255	CDD:214692	97/193 (50%)
		DEXDc	91..228	CDD:238005	82/142 (58%)
		HELICc	315..408	CDD:197757	46/92 (50%)
		HA2	478..561	CDD:214852	30/85 (35%)
		OB_NTP_bind	595..698	CDD:285018	34/103 (33%)
dhx33	NP_001093527.3	DEXDc	50..234	CDD:214692	98/194 (51%)
		DEXDc	64..207	CDD:238005	83/145 (57%)
		Helicase_C	264..381	CDD:278689	63/123 (51%)
		HA2	451..536	CDD:214852	30/84 (36%)
		OB_NTP_bind	570..670	CDD:285018	34/103 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.730