DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and dhx35

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001072515.1	Gene:	dhx35 / 779970	XenbaseID:	XB-GENE-5868299	Length:	701	Species:	Xenopus tropicalis

Alignment Length:	661	Identity:	302/661 - (45%)
Similarity:	432/661 - (65%)	Gaps:	30/661 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 KRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSCTQPRRVAAM 132
            :|..||||:.:...:.|:..:|.:|::||||.||:|||||:..:...:...:.|..||||||||:
Frog    48 QRQKLPVFKLRNHILYLVENYQTVVIIGETGCGKSTQIPQYLTEAGWTAEGRVVGVTQPRRVAAV 112

  Fly   133 SVAQRVSEEMDVKLGEEVGYSIRFEDCSTAK-TLLKYMTDGMLLREAMSDPMLDQYQVILLDEAH 196
            |||.||:||....||.||||.|||:||:..: |.:|::|||||:||.||||:|.:|.|::|||||
Frog   113 SVAGRVAEERGAVLGHEVGYCIRFDDCTDPQATRIKFLTDGMLVREMMSDPLLTRYSVLMLDEAH 177

  Fly   197 ERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYF----------DNAPLMKVPGRTHP 251
            ||||.|||.:|:||:|.::|.||:|||.||||||.||:.:|          |...::.|.|||.|
Frog   178 ERTLYTDIAIGLLKKVQKKRGDLRLVVASATLDAEKFKAFFNQNDTNDPSRDTCAILTVEGRTFP 242

  Fly   252 VEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEIG-- 314
            |:||||..|..|||::.::||::||. .::|||||.|||||||:|.....:..:...| |..|
Frog   243 VDIFYTQSPVPDYLKSTVQTVMKIHQ-SDLEGDILAFLTGQEEVESVVSMLVEQARIL-SRSGMK 305

  Fly   315 -ELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQK 378
             .|:.:|:|:.||.:.|.::||..    ::.|  |||||:|||||.|:||:|:.||||.||.|.:
Frog   306 KHLRVLPMYAGLPTSEQMKVFERV----SHSA--RKVVVATNIAEASITINGISFVIDCGFVKLR 364

  Fly   379 VYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTV 443
            .|:|:..||||:|.|:|:|||.||:||:||.|.|:|:|||||:.|. ::..:|.||:.||||..|
Frog   365 AYDPKRAVESLVVVPVSQASANQRAGRSGRNRSGQCYRLYTEEDFL-KLPPSTVPEMQRSNLAPV 428

  Fly   444 VLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTD-LGAVMSEFPLDPQLAKM 507
            :||||.||||:::.|.|:.||..:::::|||||..|..||....||: ||..|:||||:|..|||
Frog   429 ILQLKALGIDNVLRFHFLSPPPAQSMVQALELLYALGGLDKHCRLTEPLGVRMAEFPLNPMFAKM 493

  Fly   508 LIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSE 572
            |:.|....||.|||||.||:.:...||.|...|..|.....:||..:|||||:|||:.||.:.::
Frog   494 LLESGNFGCSAEILSIAAMMQIQNIFVVPPNQKSQAIREHRKFAVEEGDHLTMLNVFEAFIKFNK 558

  Fly   573 DPNWCYENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHL 637
            ..:||.:.|:|::.|..|..||:||.:::.:|.:.:.|:|.....    |.:.:|.|||...|.|
Frog   559 SSHWCQQRFLNYKGLMRAVTVREQLKKLLSKFKVPKNSSEGDPDP----ILRCIVSGFFANAAKL 619

  Fly   638 ERTGYYLTIKDNQNVQLHPSTCL--DHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYD 700
            ..||.|.|::|...:.:||::.|  :..|:||:::|.|.|.|.|:|.||.|:..||..|||.:|.
Frog   620 HSTGVYRTVRDGHELYIHPTSVLYAEKPPNWVLFSEVVQTNKYYMRDVTAVESAWLLELAPHFYQ 684

  Fly   701 LNNFPQCEAKR 711
            ........:||
Frog   685 QGTHLSRTSKR 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	13/33 (39%)
		DEXDc	67..255	CDD:214692	100/197 (51%)
		DEXDc	91..228	CDD:238005	79/137 (58%)
		HELICc	315..408	CDD:197757	46/92 (50%)
		HA2	478..561	CDD:214852	39/83 (47%)
		OB_NTP_bind	595..698	CDD:285018	37/104 (36%)
dhx35	NP_001072515.1	HrpA	7..701	CDD:224557	302/661 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010