DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and dhx37

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_002944206.3	Gene:	dhx37 / 734015	XenbaseID:	XB-GENE-986494	Length:	1147	Species:	Xenopus tropicalis

Alignment Length:	805	Identity:	249/805 - (30%)
Similarity:	387/805 - (48%)	Gaps:	165/805 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VPNKQPPTMNPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIP 106
            :|:.||....|:..:|      ::.:.|:.||:...:...|..:..:..:||.||||||||||:|
Frog   222 IPSSQPAIFIPVDRSP------DIQEARLKLPILAEEQVIMEAIKENPVVVLCGETGSGKTTQVP 280

  Fly   107 QWCVDFAVSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTD 171
            |:..:.........:..|:||||||::::|||:.||::. ...:.|.||:|...:.:|..|:|||
Frog   281 QFLYEAGYGSENDVIGITEPRRVAAIAMSQRVALEMNLP-QSVISYQIRYEGNVSNETKTKFMTD 344

  Fly   172 GMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVI----RQRSDLKLVVMSATLDAGK 232
            |:||:|...|.:|.:|:|:::||||||::.||||:|:|..::    ::.|.|||::|||||   :
Frog   345 GVLLKEIQKDFLLTRYRVVIIDEAHERSVYTDILIGLLSRIVPLRAKKGSPLKLIIMSATL---R 406

  Fly   233 FQQYFDN-------APLMKVPGRTHPVEIFYTPE-PERDYLEAAIRTVIQIHMCEEIEGDILMFL 289
            .:.:.:|       .|::||..|..||.:.:... |..||.....|.|.:||.... .|.||:||
Frog   407 IEDFTENKRLFPVPPPVIKVDARQFPVTVHFNKRTPLEDYAGECYRKVCKIHRMLP-AGGILIFL 470

  Fly   290 TGQEEIEEACKRIKR-------------------------------------EID---------- 307
            |||.|:...|:|:::                                     :||
Frog   471 TGQAEVHSLCRRLRKTFPFCGRNYHNATEDEDSQEAVRRFKKSRPKKTMNLPKIDLASYSAQPLD 535

  Fly   308 ----------------------NLGSEIGE----------LKCIPLYSTLPPNLQQRIFEPAPPP 340
                                  :||.|..|          |..:||||.|.|..|.::|.| |||
Frog   536 EGDEDREAADDEEDGSGSDLDIDLGDEGAEEDEKADSSLPLFVLPLYSLLAPEKQAKVFRP-PPP 599

  Fly   341 NANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGR 405
            ..     |..||:||:|||||||.|:.:|:|.|..|::.|:....|.|..|...|:|||.||:||
Frog   600 GT-----RLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDKVTGVSSFRVDWTSQASANQRAGR 659

  Fly   406 AGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLM 470
            ||||.||.|:|||:...|. :.:..:.|||.|..:..:|||:|.|.|:.:|:|.|..||:.:.|:
Frog   660 AGRTEPGHCYRLYSSAVFA-DFEQFSPPEITRRPVEDLVLQMKDLNIEKVVNFPFPTPPSADALI 723

  Fly   471 RALELLNYLAALDD---DGNLTD------------LGAVMSEFPLDPQLAKMLIASCQHNCSNEI 520
            .|.|||..|.||.:   .|.|.|            ||..|:.||:.|:.||||....||.|...:
Frog   724 AAEELLISLGALQEPPKTGRLNDLQKAKLSSPITPLGKTMASFPVAPRYAKMLALGRQHECLPYV 788

  Fly   521 LSITAMLSVPQCFV---RP---NEAKKAADEAKMRFAHID------------GDHLTLLNVYHAF 567
            ::|.|.::|.:.|.   ||   :|.|:.....|.|...:.            ||.:.:|....|.
Frog   789 ITIVAAMTVRELFEEVDRPAVSDEEKELLKGKKARVLQMQRIWAGQGSAQKLGDLMVMLGAVGAC 853

  Fly   568 KQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRF---------NLRRTSTEFTSKDYYVNIR 623
            :.|..:|.:|..|.:.|:::.....:|.||...::..         :.....||  |:..|  :|
Frog   854 EYSGLEPKFCERNGLRFKAMLEIRRLRGQLTTTVNSLCPDTHLYLDSKMNPPTE--SQVTY--LR 914

  Fly   624 KALVQGFFMQVAHLER---------TGYYLTIKDNQNVQLHPSTCLDHK-PDWVIYNEFVLTTKN 678
            :.::.|....:|...|         ...|.|....:.|.:||::.|..: ||:|:|.|.:.|||.
Frog   915 QIVMSGLGDHIARRIRQEELLDEKWRNAYKTPLLEEPVFIHPNSALFRQLPDFVVYQEIMETTKM 979

  Fly   679 YIRTVTDVKPEWLCCLAPQYYDLNN 703
            |::.|:.::.||:..|.|||....|
Frog   980 YMKGVSAIEAEWIPILLPQYCHFGN 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	14/51 (27%)
		DEXDc	67..255	CDD:214692	75/198 (38%)
		DEXDc	91..228	CDD:238005	62/140 (44%)
		HELICc	315..408	CDD:197757	44/102 (43%)
		HA2	478..561	CDD:214852	31/115 (27%)
		OB_NTP_bind	595..698	CDD:285018	30/121 (25%)
dhx37	XP_002944206.3	PspC_subgroup_1	<11..>243	CDD:411407	5/26 (19%)
dhx37	XP_002944206.3	HrpA	198..1002	CDD:224557	248/801 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920