DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and Dhx30

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001239612.1	Gene:	Dhx30 / 72831	MGIID:	1920081	Length:	1223	Species:	Mus musculus

Alignment Length:	726	Identity:	213/726 - (29%)
Similarity:	355/726 - (48%)	Gaps:	106/726 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PTMNPLTNTPY-----------SQRYQNLYKKR-------IALPVFEYQADFMRLLSLHQCIVLV 94
            |..:|:|..||           ||....|:::|       ..|||..::...:..:..|..:|:.
Mouse   421 PLSDPITGKPYMPLSEAEEVRLSQSLLELWRRRGPIWQEAPQLPVDPHRDTILSAIEQHPVVVIS 485

  Fly    95 GETGSGKTTQIPQWCVDFAVSKGRKGVSC----TQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIR 155
            |:||.||||:|||..::..|::|| |..|    |||||::|:|||||||.|:...|...||:.:|
Mouse   486 GDTGCGKTTRIPQLLLERYVTEGR-GARCNVIITQPRRISAVSVAQRVSHELGPSLRRNVGFQVR 549

  Fly   156 FEDCSTAK-TLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDL 219
            .|....|: ..|.:.|.|:|||:..|:|.|:....:::||.|||.:.||.|:.:||.:.|....|
Mouse   550 LESKPPARGGALLFCTVGILLRKLQSNPSLEGVSHVIVDEVHERDVNTDFLLILLKGLQRLNPAL 614

  Fly   220 KLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYT------------PEPERDY-------L 265
            :||:||||.|..:|.:||...|::||||..:||:..|.            |...|.:       |
Mouse   615 RLVLMSATGDNERFSRYFGGCPVIKVPGFMYPVKEHYLEDILAKLGKHQYPHRHRHHESEDECAL 679

  Fly   266 EAAIRTVIQIHMCEEIE-GDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNL 329
            :..:.|.:.:|:....| |.||.||.|.:||:...:|::   :.||....:...:|::|.:|...
Mouse   680 DLDLVTDLVLHIDARGEPGGILCFLPGWQEIKGVQQRLQ---EALGMHESKYLILPVHSNIPMMD 741

  Fly   330 QQRIFEPAPPPNANGAIG-RKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSP 393
            |:.||:..|       :| ||:|::|||||||:|::.:|.|:|.|..|::.|:.:.:|..|....
Mouse   742 QKAIFQQPP-------LGVRKIVLATNIAETSITVNDIVHVVDSGLHKEERYDLKTKVSCLETVW 799

  Fly   394 ISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHF 458
            :|:|:..||.|||||.:.|..:.|:.....: :|.....|||||:.|..:||| .|:.:.:....
Mouse   800 VSRANVIQRRGRAGRCQSGFAYHLFPRSRLE-KMVPFQVPEILRTPLENLVLQ-AKIHMPEKTAV 862

  Fly   459 DFM----DPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNE 519
            :|:    |.|..:.:..|:.||..:..||....||.||..::....||:|||.::.:....|.:.
Mouse   863 EFLSKAVDSPNIKAVDEAVILLQEIGVLDQREYLTTLGQRLAHISTDPRLAKAIVLAAIFRCLHP 927

  Fly   520 ILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDG-DHLTLLNVYHAFKQ------SSEDPNWC 577
            :|.:.:.|: ...|....:.:...|:.|...:|..| |||..:.....:::      .:...|:.
Mouse   928 LLVVVSCLT-RDPFSSSLQNRAEVDKVKALLSHDSGSDHLAFVRAVAGWEEVLRWQDRTSRENYL 991

  Fly   578 YENFINFRSLKSADNVRQQLA-RIMDRFNLRRTS---------TEFTSKDYYVNIRKALVQGFF- 631
            .||.:...||:....:.:|.: .|.:.|.:.:.|         .|::.::..|  :..|:.|.:
Mouse   992 EENLLYAPSLRFIHGLIKQFSENIYEAFLVGKPSDCTLPSAQCNEYSEEEELV--KGVLMAGLYP 1054

  Fly   632 --MQV--AHLERTGYYLTIKDNQ--------NVQLHPST----CLDHKPDWVIYNEFVLTTKN-- 678
              :||  ..:.|.|.:   |.|.        |:.||.||    ....:..|:.|  |:....|
Mouse  1055 NLIQVRQGKVTRQGKF---KPNSVTYRTKSGNILLHKSTINREATRLRSRWLTY--FMAVKSNGS 1114

  Fly   679 -YIRTVTDVKP 688
             ::|..:.|.|
Mouse  1115 VFVRDSSQVHP 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	17/69 (25%)
		DEXDc	67..255	CDD:214692	79/199 (40%)
		DEXDc	91..228	CDD:238005	62/141 (44%)
		HELICc	315..408	CDD:197757	34/93 (37%)
		HA2	478..561	CDD:214852	22/83 (27%)
		OB_NTP_bind	595..698	CDD:285018	26/124 (21%)
Dhx30	NP_001239612.1	DEXDc	467..646	CDD:214692	73/179 (41%)
		DEXDc	481..622	CDD:238005	61/141 (43%)
		HELICc	715..814	CDD:197757	37/108 (34%)
		HA2	886..969	CDD:214852	22/83 (27%)
		OB_NTP_bind	1009..1131	CDD:285018	26/124 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810