DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and Dhx36

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_082412.2	Gene:	Dhx36 / 72162	MGIID:	1919412	Length:	1001	Species:	Mus musculus

Alignment Length:	792	Identity:	239/792 - (30%)
Similarity:	385/792 - (48%)	Gaps:	154/792 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKG----V 121
            ||..:.:.|..||.:..|.:.:.|::.||..|:.||||.|||||:.|:.:|..:.:| ||    :
Mouse   189 RYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERG-KGSACRI 252

  Fly   122 SCTQPRRVAAMSVAQRVSEEMDVKL--GEEVGYSIRFEDCSTAKT-LLKYMTDGMLLREAMSDPM 183
            .||||||::|:|||:||:.|.....  |...||.||.:.....|. .:.|.|.|::|:...||..
Mouse   253 VCTQPRRISAISVAERVATERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSR 317

  Fly   184 LDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGR 248
            |.....|:|||.|||.|.:|:||.|:|:::..|||||:::|||||:|.||.:||.|.|::.:||.
Mouse   318 LSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHIPGF 382

  Fly   249 THPV----------EIFYTPE-------------------PERDYLEA----------------- 267
            |.||          :|.|.|:                   .|::..||
Mouse   383 TFPVVEYLLEDIIEKIRYVPDQKEHRSQFKRGFMQGHVNRQEKEEKEAIYKERWPAYIKELRTRY 447

  Fly   268 -------------------AIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREIDNLGSEI 313
                               .|..:|:..:.||.:|.||:||.|.:.|...       .|.|.|::
Mouse   448 SASTVDVLQMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTL-------HDLLMSQV 505

  Fly   314 ----GELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGF 374
                .:...|||:|.:|...|.::|:..||    |.  ||:|::|||||||:|||.||:|||.|.
Mouse   506 MFKSDKFLIIPLHSLMPTVNQTQVFKKTPP----GV--RKIVIATNIAETSITIDDVVYVIDGGK 564

  Fly   375 AKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSN 439
            .|:..::.:..:.::....:|||:|:||.|||||.:||.|:.||.... .:.:.|...|||||:.
Mouse   565 IKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNGLR-ASLLDDYQLPEILRTP 628

  Fly   440 LGTVVLQLKKLGIDDLVHF--DFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDP 502
            |..:.||:|.|.:..:.:|  ..||||:.|.::.:::.|..|:|||....||.||..::..|::|
Mouse   629 LEELCLQIKILRLGGIAYFLSRLMDPPSNEAVVLSIKHLMELSALDKQEELTPLGVHLARLPVEP 693

  Fly   503 QLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFA-HIDGDHLTLLNVYHA 566
            .:.||::......|.:.:|:|.|.||....||.|...:|.||..:...| ....||||::|.:..
Mouse   694 HIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKETRSDHLTVVNAFEG 758

  Fly   567 FKQSSE-----DPNWCYENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTS----KDYYVNI 622
            ::::..     :.::|:|.|::..:|:...|::.|.|..:       ....|.|    ||...||
Mouse   759 WEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHL-------LGAGFVSSRSPKDPKANI 816

  Fly   623 R-------KALV-QGFFMQVAHL------ERTGYYLTIKDNQNVQLHPSTC----LDHKPDWVIY 669
            .       ||:: .|.:.:||.:      :|....:..|.:..|.:||.:.    .|...:|:||
Mouse   817 NSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVHTKSDGLVSIHPKSVNVEQTDFHYNWLIY 881

  Fly   670 NEFVLTTKNYIRTVTDVKP------------------------EWLCCLAPQYYDLNNFPQCEAK 710
            :..:.|:..|:...|:|.|                        ||:...:|:  .:.:..:...|
Mouse   882 HLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDKDQEIIAVDEWIVFQSPE--RIAHLVKGLRK 944

  Fly   711 RQLELLQQRLET 722
            ....|||:::|:
Mouse   945 ELDSLLQEKIES 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	15/40 (38%)
		DEXDc	67..255	CDD:214692	83/204 (41%)
		DEXDc	91..228	CDD:238005	62/143 (43%)
		HELICc	315..408	CDD:197757	39/92 (42%)
		HA2	478..561	CDD:214852	29/83 (35%)
		OB_NTP_bind	595..698	CDD:285018	30/148 (20%)
Dhx36	NP_082412.2	Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..193		2/3 (67%)
		Required for the pre-miR-134 transport. /evidence=ECO:0000250\|UniProtKB:D4A2Z8	1..97
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	1..44
		Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	46..98
		DSM (DHX36-specific motif). /evidence=ECO:0000250\|UniProtKB:Q05B79, ECO:0000250\|UniProtKB:Q9H2U1	46..68
		RecA-like domain 1. /evidence=ECO:0000250\|UniProtKB:Q05B79	99..379		80/190 (42%)
		HrpA	188..894	CDD:224557	228/726 (31%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	258..310		18/51 (35%)
		DEAH box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	327..330		2/2 (100%)
		RecA-like domain 2. /evidence=ECO:0000250\|UniProtKB:Q05B79	380..621		72/254 (28%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	491..550		22/71 (31%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9H2U1	510..521		4/10 (40%)
		WH domain. /evidence=ECO:0000250\|UniProtKB:Q05B79	622..691		25/68 (37%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	631..690		19/58 (33%)
		OB-fold-like subdomains. /evidence=ECO:0000250\|UniProtKB:Q05B79	834..898		14/63 (22%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	842..853		1/10 (10%)
		Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250\|UniProtKB:Q05B79	863..893		8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820