DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and Dhx40

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_080467.3	Gene:	Dhx40 / 67487	MGIID:	1914737	Length:	779	Species:	Mus musculus

Alignment Length:	710	Identity:	275/710 - (38%)
Similarity:	412/710 - (58%)	Gaps:	58/710 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LGGFVPNKQPPTMNPL---TNTPYSQRYQNLYKKRI------ALPVFEYQADFMRLLSL---HQC 90
            :.|..|.:|.....|:   ...|.:.|..:..:|..      ..|.|..|....:|:..   :..
Mouse     7 VAGRAPRRQEEGERPIELQEERPSAVRIADREEKGCTSQEGGTTPTFPIQKQRKKLIQAVRDNSF 71

  Fly    91 IVLVGETGSGKTTQIPQWCVDFAVSK-GRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSI 154
            :::.|.||||||||:|::..:...|: |..||  ||||:|||:||||||:|||...||.:|||.:
Mouse    72 LIVTGNTGSGKTTQLPKYLYEAGFSQHGMIGV--TQPRKVAAISVAQRVAEEMKCTLGSKVGYQV 134

  Fly   155 RFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRS-- 217
            ||:|||:.:|.:||||||.||:..:.||.|.::.||:|||||||||.||||.|:||::.:.:|
Mouse   135 RFDDCSSKETAIKYMTDGCLLKHILGDPNLSKFSVIILDEAHERTLTTDILFGLLKKLFQDKSPN 199

  Fly   218 ---DLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPV-EIFYTPEPERD-----YLEAAIRTVI 273
               .||:||||||::..|...:|.|.|:..:|||.:|| |.|......||     |::|.::..:
Mouse   200 RKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTM 264

  Fly   274 QIHMCEEIEGDILMFLTGQEEIEEAC-------KRIKREIDNLGSEIGELKCIPLYSTLPPNLQQ 331
            .||: .|:.||||:|||||.|||::|       :.:..:.|...:.:..|..:|.|.::..:.|:
Mouse   265 DIHL-NEMAGDILVFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQR 328

  Fly   332 RIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISK 396
            |||.| |||..     ||.|:||||:.|||||||:.:|:|.||.||..:|||:.::.|.|.||||
Mouse   329 RIFLP-PPPGI-----RKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISK 387

  Fly   397 ASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFM 461
            :.|.|||||||||..|||||:|:::.:...|.|:..|||.|::|.:|||.||.|.|.|::.|.::
Mouse   388 SEALQRSGRAGRTASGKCFRIYSKEFWSQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYL 452

  Fly   462 DPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAM 526
            |||....::.||:.|....|:|..|::|.||..|.||||.|.|...:|.:...:|.:.:|.|.||
Mouse   453 DPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIRAASLDCEDLLLPIAAM 517

  Fly   527 LSVPQCFVRP--NEAKKAADEAKMRFAHIDG---DHLTLLNVYHAFKQSSEDPNWCYENFINFRS 586
            |||...|:||  .|.:|.|::.....|...|   |..||..::...|.|....:||.:::|::|.
Mouse   518 LSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSSGAPASWCQKHWIHWRC 582

  Fly   587 LKSADNVRQQLARIMDRFNLRRTSTEFTSKDY----YVNIRKALVQGFFMQVAHLERTGYYLTIK 647
            |.||..|..||..::.:.   :..::|..:.:    :..:|:.|..|:|..||. ...|......
Mouse   583 LFSAFRVEAQLRELIRKL---KQQSDFPRETFEGPKHEVLRRCLCAGYFKNVAR-RSVGRTFCTM 643

  Fly   648 DNQN--VQLHPSTCL---DHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDLN 702
            |.:.  |.:|||:.|   :.|.:|:|::|.::|||.|.|.|..::.||:..|.|:.::||
Mouse   644 DGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKLHELN 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	13/63 (21%)
		DEXDc	67..255	CDD:214692	94/203 (46%)
		DEXDc	91..228	CDD:238005	78/142 (55%)
		HELICc	315..408	CDD:197757	47/92 (51%)
		HA2	478..561	CDD:214852	32/87 (37%)
		OB_NTP_bind	595..698	CDD:285018	30/111 (27%)
Dhx40	NP_080467.3	OB_NTP_bind	591..699	CDD:285018	30/111 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53		8/45 (18%)
		DEXDc	48..236	CDD:214692	90/189 (48%)
		DEXDc	78..213	CDD:238005	77/136 (57%)
		DEAH box	173..176		2/2 (100%)
		HELICc	312..399	CDD:197757	47/92 (51%)
		HA2	469..557	CDD:214852	32/87 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820