DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and YTHDC2

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_011541883.1	Gene:	YTHDC2 / 64848	HGNCID:	24721	Length:	1439	Species:	Homo sapiens

Alignment Length:	905	Identity:	231/905 - (25%)
Similarity:	373/905 - (41%)	Gaps:	282/905 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVS 115
            |.:...|..:........|.:|||||.|.:.::::..::.:::||||||||||||||:.:|....
Human   172 NGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFK 236

  Fly   116 KGRK-GVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAM 179
            .|.. .:.||||||:||::||:||:.|...::|:.:||.||.|...:.||||.:.|:|:|||..|
Human   237 NGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLM 301

  Fly   180 S-DPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLM 243
            : |..|.....:::||.|||...:|.|:..|::::::...|||::.||.||...|.:||.:.|::
Human   302 AGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVI 366

  Fly   244 KVPGRTHPV-EIF---------YT---------------------------------PEPER--- 262
            .:.||...| |:|         ||                                 ||.:|
Human   367 YIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRT 431

  Fly   263 ----------------------------------------------------------------- 262

Human   432 VLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTEN 496

  Fly   263 ---DY------------------------------------------------------------ 264
               ||
Human   497 VSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLES 561

  Fly   265 ----------------------LEAAIRTVIQ-----------------------IHMCEEIEGD 284
                                  |.|..|.:::                       .|.|:  .|.
Human   562 YSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCD--AGA 624

  Fly   285 ILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRK 349
            :|:||.|.:||.....||..:...........:...|:|.:..:.|:::.: .||...     ||
Human   625 VLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLK-NPPAGV-----RK 683

  Fly   350 VVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKC 414
            :::||||||||:|::.||||||.|..|:|.::....|..|.:..||||||.||.|||||.|||.|
Human   684 IILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGIC 748

  Fly   415 FRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFM----DPPAPETLMRALEL 475
            |||::...|:|.::..| ||:||..|..:.|..|.|...:....||:    :||....:..|:::
Human   749 FRLFSRLRFQNMLEFQT-PELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQM 812

  Fly   476 LNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEA- 539
            |..:.|:|...:||:||..:::.|::|.|.||::.:....|.:.||:|...|:....||.|.:|
Human   813 LKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQAS 877

  Fly   540 -KKAADEAKMRF-AHIDGDHLTLLNVYHAFKQSSEDPNW----CYENFINFRSLKSADNVRQQL- 597
             |:||...:.|| |....||:.||..:.|::::..| .|    |.:||::..:::....:|.||
Human   878 QKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSD-GWERAFCEKNFLSQATMEIIIGMRTQLL 941

  Fly   598 --------ARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQL 654
                    .|.....::|..:|  .|:::.| ::.|||.|.:..:.|::|....||....:.|:.
Human   942 GQLRASGFVRARGGGDIRDVNT--NSENWAV-VKAALVAGMYPNLVHVDRENLVLTGPKEKKVRF 1003

  Fly   655 HPSTCLDH-------------------KPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLA 695
            ||::.|..                   ..||:||:|  :|..:.|..:.       ||.|
Human  1004 HPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDE--MTRAHRIANIR-------CCSA 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	16/50 (32%)
		DEXDc	67..255	CDD:214692	77/190 (41%)
		DEXDc	91..228	CDD:238005	60/138 (43%)
		HELICc	315..408	CDD:197757	38/92 (41%)
		HA2	478..561	CDD:214852	28/85 (33%)
		OB_NTP_bind	595..698	CDD:285018	29/129 (22%)
YTHDC2	XP_011541883.1	R3H_DEXH_helicase	46..104	CDD:100077
		HrpA	189..>1016	CDD:224557	219/839 (26%)
		DEXHc_YTHDC2	193..368	CDD:350745	72/174 (41%)
		ANK repeat	505..537	CDD:293786	0/31 (0%)
		ANK repeat	539..564	CDD:293786	0/24 (0%)
		OB_NTP_bind	971..1066	CDD:369483	22/93 (24%)
		YTH	1288..1404	CDD:367840
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810