DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and dhx8

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_002663993.1	Gene:	dhx8 / 606595	ZFINID:	ZDB-GENE-050809-39	Length:	1210	Species:	Danio rerio

Alignment Length:	754	Identity:	353/754 - (46%)
Similarity:	494/754 - (65%)	Gaps:	64/754 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KAKKDPEASSSSAAAAAGTVA------------------------------------QILG---- 39
            |..|:|:.|.|.||.....:|                                    ||..
Zfish   453 KIVKNPDGSLSQAAMMQSALAKERREVKQAQREAEMDSIPMGLNKHWVDPLPDVDGRQIAANMRG 517

  Fly    40 -GFVPNKQPPTMNPL---TNTPYSQRYQ-NLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGS 99
             |.:||..|......   ....|.::.| ::.::|.:||:::.:...::.:..:|.::::|||||
Zfish   518 IGMMPNDIPEWKKHAFGGNKASYGKKTQLSILEQRESLPIYKLKEQLIQAVHDNQILIVIGETGS 582

  Fly   100 GKTTQIPQWCVDFA-VSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAK 163
            ||||||.|:..:.. .::|:  :.|||||||||||||:|||||....||:||||:||||||::.:
Zfish   583 GKTTQITQYLAEAGYTTRGK--IGCTQPRRVAAMSVAKRVSEEYGCCLGQEVGYTIRFEDCTSPE 645

  Fly   164 TLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATL 228
            |::|||||||||||.:.||.|.||.:|:||||||||:.||:|.|:||:.:::|:|:||:|.||||
Zfish   646 TVIKYMTDGMLLRECLIDPDLGQYAIIMLDEAHERTIHTDVLFGLLKKTVQKRTDMKLIVTSATL 710

  Fly   229 DAGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQE 293
            ||.||.|||..||:..:||||:|||:.||.|||.|||:|::.||:|||:.|. .||||:||||||
Zfish   711 DAVKFSQYFYEAPIFTIPGRTYPVEVLYTKEPETDYLDASLITVMQIHLTEP-PGDILVFLTGQE 774

  Fly   294 EIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAE 358
            ||:.||:.:...:.:||.::.||..:|:||.||..:|.|||:||||.:      ||||::|||||
Zfish   775 EIDTACEILYERMKSLGPDVPELIILPVYSALPSEMQTRIFDPAPPGS------RKVVIATNIAE 833

  Fly   359 TSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAF 423
            |||||||:.:|:||||.||||||.:..::.|:|:|||:|.|:||:||||||.||||:|||||:|:
Zfish   834 TSLTIDGIYYVVDPGFVKQKVYNSKTGIDQLVVTPISQAQAKQRAGRAGRTGPGKCYRLYTERAY 898

  Fly   424 KNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNL 488
            ::||.....|||.|:||.:.||.||.:||:||:.|||||.|..|||:.|:|.|..|.||||:|.|
Zfish   899 RDEMLTTNVPEIQRTNLASTVLSLKAMGINDLLSFDFMDAPPMETLITAMEQLYTLGALDDEGLL 963

  Fly   489 TDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHI 553
            |.||..|:||||:|.|.||||.|....||.|:|:|.:||||...|.||.:.:..||:.|.:|...
Zfish   964 TRLGRRMAEFPLEPMLCKMLIMSVHLGCSEEMLTIVSMLSVQNVFYRPKDKQALADQKKAKFHQP 1028

  Fly   554 DGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDY 618
            :|||||||.||:::|.:.....|||||||..|||:.|.::|:|:..||||..|...|....:
Zfish  1029 EGDHLTLLAVYNSWKNNKFSNPWCYENFIQARSLRRAQDIRKQMLGIMDRHKLDVVSCGKAT--- 1090

  Fly   619 YVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCL-DHKPDWVIYNEFVLTTKNYIRT 682
             |.::||:..|||...|..:....|.|:.|.|.|.:|||:.| :.:|:||:|:|.|||||.|:|.
Zfish  1091 -VRVQKAICSGFFRNAAKKDPQEGYRTLIDQQVVYIHPSSALFNRQPEWVVYHELVLTTKEYMRE 1154

  Fly   683 VTDVKPEWLCCLAPQYYDLNNFPQCEAKRQLELLQQRLE 721
            ||.:.|.||...||.::.:::..:...:::    |||||
Zfish  1155 VTTIDPRWLVEFAPAFFKVSDPTRLSKQKK----QQRLE 1189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	12/55 (22%)
		DEXDc	67..255	CDD:214692	104/188 (55%)
		DEXDc	91..228	CDD:238005	82/137 (60%)
		HELICc	315..408	CDD:197757	54/92 (59%)
		HA2	478..561	CDD:214852	43/82 (52%)
		OB_NTP_bind	595..698	CDD:285018	42/103 (41%)
dhx8	XP_002663993.1	S1_DHX8_helicase	257..333	CDD:240189
dhx8	XP_002663993.1	HrpA	542..1209	CDD:224557	338/665 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.730