Protein Alignment Dhx15 and DHX35

DIOPT Version :10

• Sequence 1: NP_610269.1
• Gene: Dhx15 / 35654
• FlyBaseID: FBgn0033160
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_068750.2
• Gene: DHX35 / 60625
• HGNCID: 15861
• Length: 703
• Species: Homo sapiens
• Alignment Length: 672
• Identity: 304/672 - (45%)
• Similarity: 438/672 - (65%)
• Gaps: 32/672 - (4%)

  Fly    57 PYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGV 121
            ||:.  .::.::|..||||:.:...:.|:..:|.:|:|||||.||:|||||:..:...:...:.|
Human    41 PYAA--LSIEQQRQKLPVFKLRNHILYLIENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVV 103

  Fly   122 SCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCS-TAKTLLKYMTDGMLLREAMSDPMLD 185
            ..||||||||::||.||:||....||.||||.|||:||: ...|.:|::|||||:||.|.||:|.
Human   104 GVTQPRRVAAVTVAGRVAEERGAVLGHEVGYCIRFDDCTDQLATRIKFLTDGMLVREMMVDPLLT 168

  Fly   186 QYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYF----------DNA 240
            :|.||:|||||||||.|||.:|:||::.::|.||:|:|.||||||.||:.:|          |..
Human   169 KYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDADKFRDFFNQNETSDPARDTC 233

  Fly   241 PLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRI--- 302
            .::.|.|||.||:|||...|..||:::.:.||::||..|. :||:|.|||||||:|.....:
Human   234 VILTVEGRTFPVDIFYLQSPVPDYIKSTVETVVKIHQTEG-DGDVLAFLTGQEEVETVVSMLIEQ 297

  Fly   303 KREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVV 367
            .|.:...|.: ..|:.:|:|:.||...|.::||     ..:.:: |||:|:||:||||:||.|:|
Human   298 ARALARTGMK-RHLRVLPMYAGLPSFEQMKVFE-----RVSRSV-RKVIVATNVAETSITISGIV 355

  Fly   368 FVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTY 432
            :|||.||.|.:.||||..:|.|:|.|:|:|||.||:||.||:|.|||:|||||:|| :::..:|.
Human   356 YVIDCGFVKLRAYNPRTAIECLVVVPVSQASANQRAGRGGRSRSGKCYRLYTEEAF-DKLPQSTV 419

  Fly   433 PEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTD-LGAVMS 496
            ||:.||||..|:||||.||||:::.|.||.||..:::::|||||..|..||.|..||: ||..::
Human   420 PEMQRSNLAPVILQLKALGIDNVLRFHFMSPPPAQSMVQALELLYALGGLDKDCRLTEPLGMRIA 484

  Fly   497 EFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLL 561
            ||||:|..||||:.|....||.|||||.||:.:...||.|...|..|.....:||..:|||||:|
Human   485 EFPLNPMFAKMLLESGNFGCSQEILSIAAMMQIQNIFVVPPNQKSHAIRVHRKFAVEEGDHLTML 549

  Fly   562 NVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDYYVNIRKAL 626
            |:|.||.:.::|..||.|:|:|::.|..|..||:||.:::.:|.:.|.|:| ...|.   :.:.:
Human   550 NIYEAFIKHNKDSKWCQEHFLNYKGLVRAATVREQLKKLLVKFQVPRKSSE-GDPDL---VLRCI 610

  Fly   627 VQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCL--DHKPDWVIYNEFVLTTKNYIRTVTDVKPE 689
            |.|||...|....||.|.||:|:..:.:||::.|  :..|.||||||.:.|:|.|:|.||.::..
Human   611 VSGFFANAARFHSTGAYRTIRDDHELHIHPASVLYAEKPPRWVIYNEVIQTSKYYMRDVTAIESA 675

  Fly   690 WLCCLAPQYYDLNNFPQCEAKR 711
            ||..|||.:|........:|||
Human   676 WLLELAPHFYQQGTHLSLKAKR 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_610269.1	HrpA	71..>691	CDD:441249	292/636 (46%)
DHX35	NP_068750.2	HrpA	54..>701	CDD:441249	301/657 (46%)
		DEAH box	176..179		2/2 (100%)