Protein Alignment Dhx15 and DHX37

DIOPT Version :10

• Sequence 1: NP_610269.1
• Gene: Dhx15 / 35654
• FlyBaseID: FBgn0033160
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: XP_005253647.1
• Gene: DHX37 / 57647
• HGNCID: 17210
• Length: 1175
• Species: Homo sapiens
• Alignment Length: 869
• Identity: 257/869 - (29%)
• Similarity: 402/869 - (46%)
• Gaps: 194/869 - (22%)

  Fly    14 SKAKKDPEASSSSAAAAAGTVAQILGGFVPNKQP--------------PTM-----NPLTNTPYS 59
            |:..:||.|..:.|.... |||.:.....|:.||              |.:     .|....|.:
Human   177 SELDEDPAAEPAEAGVGT-TVAPLPPAPAPSSQPVPAGMTVPPPPAAAPPLPRALAKPAVFIPVN 240

  Fly    60 QRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSCT 124
             |...:.::|:.||:...:...|..::.|..:::.||||||||||:||:..:...|.....:..|
Human   241 -RSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGFSSEDSIIGVT 304

  Fly   125 QPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQV 189
            :||||||::::|||::||::. ...|.|.||:|...|.:|.:|:||||:||:|...|.:|.:|:|
Human   305 EPRRVAAVAMSQRVAKEMNLS-QRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKV 368

  Fly   190 ILLDEAHERTLATDILMGVLKEVIRQRS----DLKLVVMSATLDAGKFQQ----YFDNAPLMKVP 246
            :::||||||::.||||:|:|..::..|:    .|||::|||||....|.|    :....|::||.
Human   369 VIIDEAHERSVYTDILIGLLSRIVTLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKPPPVIKVE 433

  Fly   247 GRTHPVEIFYTPE-PERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKR------ 304
            .|..||.:.:... |..||.....|.|.:||.... .|.||:|||||.|:...|:|:::
Human   434 SRQFPVTVHFNKRTPLEDYSGECFRKVCKIHRMLP-AGGILVFLTGQAEVHALCRRLRKAFPPSR 497

  Fly   305 ---------------------------------------------------------EID----- 307
                                                                     |:|
Human   498 ARPQEKDDDQKDSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVDEEEGA 562

  Fly   308 ---NLGSEIGE--------------LKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTN 355
               :|..::|:              |..:||||.|.|..|.::|:  |||...    |..||:||
Human   563 LDSDLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFK--PPPEGT----RLCVVATN 621

  Fly   356 IAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTE 420
            :|||||||.|:.:|:|.|..|::.|:....|.|..|:.:|:|||.||:||||||.||.|:|||:.
Human   622 VAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSS 686

  Fly   421 KAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDD 485
            ..| .:.:....|||.|..:..::||:|.|.::.:::|.|..||:.|.|:.|.|||..|.||...
Human   687 AVF-GDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALGALQPP 750

  Fly   486 GN---------------LTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFV- 534
            ..               :|.||..|:.||:.|:.||||..|.||.|....::|.|.::|.:.|.
Human   751 QKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEE 815

  Fly   535 --RPNEAKKAADEAKMRFAHID---------------GDHLTLLNVYHAFKQSSEDPNWCYENFI 582
              ||..:.:.....|.:.|.:.               ||.:.||....|.:.:|..|.:|..|.:
Human   816 LDRPAASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCTPQFCEANGL 880

  Fly   583 NFRSLKSADNVRQQLAR-----------IMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAH 636
            .::::.....:|.||..           .:|......|.::.|      .:|:.:..|....:|.
Human   881 RYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVT------YLRQIVTAGLGDHLAR 939

  Fly   637 -------LE---RTGYYLTIKDNQNVQLHPSTCL-DHKPDWVIYNEFVLTTKNYIRTVTDVKPEW 690
                   ||   |..|...:.|:. |.:|||:.| ...|::|:|.|.|.|||.|::.|:.|:.:|
Human   940 RVQSEEMLEDKWRNAYKTPLLDDP-VFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQW 1003

  Fly   691 LCCLAPQYYDLNNFPQCEAKRQLE 714
            :..|.|.|        |:..:.||
Human  1004 IPALLPSY--------CQFDKPLE 1019

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_610269.1	HrpA	71..>691	CDD:441249	234/768 (30%)
DHX37	XP_005253647.1	HrpA	252..>1043	CDD:441249	241/792 (30%)