DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and dhx30

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_021322211.1	Gene:	dhx30 / 570735	ZFINID:	ZDB-GENE-130530-833	Length:	1173	Species:	Danio rerio

Alignment Length:	755	Identity:	218/755 - (28%)
Similarity:	368/755 - (48%)	Gaps:	108/755 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KKDPEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYK-----KRIALPVFE 76
            :::.::||.|.||......:.:...:.:|....:.|......|||..:::|     :...|||..
Zfish   334 EEEHQSSSISTAADDYDEDEFITDAITSKPYRALEPKEAEHLSQRLLSMWKRVGPARGAELPVDA 398

  Fly    77 YQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSC----TQPRRVAAMSVAQR 137
            ::...:..:...|.:|:.||||.||||:||::.::..|.:| :|..|    |||||::|:|||||
Zfish   399 HKESILEAVRSSQVVVISGETGCGKTTRIPRFLLEDGVLRG-EGAECNVLVTQPRRISAVSVAQR 462

  Fly   138 VSEEMDVKLGEEVGYSIRFEDCSTAKT--LLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTL 200
            |:.|:...|...|||.:|.|.....::  .|.::|.|:||::..|:|.|:....:::||.|||.:
Zfish   463 VAHEIGPALQHCVGYQVRLESRPPERSGGALLFLTLGVLLKKLQSNPRLEGISHVIVDEVHERDV 527

  Fly   201 ATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPERDY- 264
            .||:|:.:|:.|:..|.:||:::|||:.|:.:..|||...|:::|||..|||...:..:.:.|.
Zfish   528 QTDLLLHLLRCVLSLRPELKVLLMSASGDSQRLAQYFGGCPVLRVPGFMHPVRARFLEDMQLDSR 592

  Fly   265 -----------------------------LEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACK 300
                                         |:.....:..||...| .|.:|.||.|.:||:...:
Zfish   593 RPLLDMGSTQWSAEVRGRMGKEENNVTPDLDLVADVIDHIHRTGE-PGAVLCFLPGWQEIKAVQQ 656

  Fly   301 RI-KREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTID 364
            :: :::....||:|    .:||:|::..:.||.:|:..|      |..||:|::|||||||:|||
Zfish   657 QLEEKQAYRSGSQI----ILPLHSSMAVSEQQVVFQRPP------AGQRKIVLATNIAETSITID 711

  Fly   365 GVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQD 429
            .:|.|:|.|..|::.|:||.:|.:|....||:|:..||.|||||.:||..:.|:..|..: .|:.
Zfish   712 DIVHVVDAGVQKEQNYDPRTKVSALNTVWISQANVTQRRGRAGRCQPGHSYHLFPRKQLE-RMEP 775

  Fly   430 NTYPEILRSNLGTVVLQLKKLGIDDLVHF------DF----MDPPAPETLMRALELLNYLAALDD 484
            ...|||||:.|.:||:|.|       :|.      ||    :|.|..:.:..|::.|..:..||.
Zfish   776 FPVPEILRTPLESVVMQAK-------IHCPESKAEDFLSQVLDSPDTQAVRTAVKNLMDIGVLDA 833

  Fly   485 DGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMR 549
            ..:||.||..:|....||:|.|:|:.|...:|...:||:.|.|: ...|....:.:....:||..
Zfish   834 SEDLTPLGHHVSCMSCDPRLGKVLVFSALFSCVQPVLSVVACLT-RDPFYNSLQNRTLVSKAKAE 897

  Fly   550 FAHIDG-DHLTLLNVYHAFK-QSSEDPNWCY--ENFINFRSLKSADNVRQQLARIMDRFNLRRTS 610
            .:...| |:|....|..::: |.|.|....|  ::.::..||:....:.||.:..:....|...|
Zfish   898 LSGSSGSDYLVFSRVVQSWREQHSRDSRQDYLDKHTLSGASLRFIHGLMQQFSDNLCEAGLVDHS 962

  Fly   611 TEFTSKDYYVN--------IRKALVQGFFMQVAHLE-----RTGYYLTIKDNQNVQ--------- 653
            .|.......||        |...|:.|.:..:..::     ::|.:..    :||.
Zfish   963 AECLRLSSPVNQQSKEEQLITAVLLAGLYPNLIQVKKGVVTKSGRFRA----ENVSFRTESGPVL 1023

  Fly   654 LHPSTC-LDHKPDWVIYNEFVLTTKN----YIRTVTDVKP 688
            ||.|:. .|.:..|..:..|....|:    :||..|.|.|
Zfish  1024 LHRSSVNRDKQHLWSRWLTFFSAVKSSGQVFIRDSTVVHP 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	15/56 (27%)
		DEXDc	67..255	CDD:214692	74/198 (37%)
		DEXDc	91..228	CDD:238005	58/142 (41%)
		HELICc	315..408	CDD:197757	39/92 (42%)
		HA2	478..561	CDD:214852	24/83 (29%)
		OB_NTP_bind	595..698	CDD:285018	25/121 (21%)
dhx30	XP_021322211.1	HrpA	371..>929	CDD:224557	183/578 (32%)
dhx30	XP_021322211.1	OB_NTP_bind	947..1069	CDD:311586	25/121 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810