DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and dhx57

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_001921063.3	Gene:	dhx57 / 555250	ZFINID:	ZDB-GENE-030131-4078	Length:	1431	Species:	Danio rerio

Alignment Length:	797	Identity:	226/797 - (28%)
Similarity:	378/797 - (47%)	Gaps:	176/797 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 SQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGR----K 119
            |:||.::.::|..||.::.:...:..|..:|.:|:.|.||.||||||||:.:|..:..||    .
Zfish   570 SRRYISMQEQRQKLPAWQKREAILECLVKNQVLVISGMTGCGKTTQIPQFILDNFLQTGRPDRVA 634

  Fly   120 GVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPML 184
            .:.||||||::|::||.||::|....||...||.||.|...::.|.|.:.|.|:|||....||.|
Zfish   635 NIICTQPRRISAIAVATRVAQERAEALGHSTGYQIRLETVRSSITRLMFCTTGVLLRRLEGDPEL 699

  Fly   185 DQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRT 249
            .....:::||.||||..:|.|:.|||::|.:|:|||:::|||||:|..|.|||:|.|.:.:||||
Zfish   700 SGVTHVIVDEVHERTEESDFLLLVLKDLIVKRTDLKVIMMSATLNAELFSQYFNNCPCIHIPGRT 764

  Fly   250 HPVEIFYTPE------------------------------------------------------- 259
            .|||.|:..:
Zfish   765 FPVEQFFLEDAIAKTRYVIEDGSPYRRSTKLNRSSGPGGKTGKGRALVEDFDDDYGGWSFTSFRN 829

  Fly   260 --------PER------------DYLEAAIRTV-------IQIHMCEE-----IEGD-------I 285
                    |::            :|.::.::|:       |.:.:.|.     ::||       :
Zfish   830 KESVKDSVPDQQLSQQDLTVRYSNYSKSVVKTLAAMDLDKINMDLVESLLEWIVDGDHSYPPGAV 894

  Fly   286 LMFLTGQEEIEEACKRIK--REIDNLGSEIGELKCI--PLYSTLPPNLQQRIF-EPAPPPNANGA 345
            |:||.|..||::..::::  |..:|..:.    :|:  ||:|:|....||.:| .|     .||.
Zfish   895 LVFLPGLAEIKQLYEQLQSNRMFNNRRTN----RCVVYPLHSSLSNEEQQAVFTRP-----QNGV 950

  Fly   346 IGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTR 410
              .|:::||||||||:|||.||:|||.|..|:|.|:....:|||....:|:|:|.||.|||||..
Zfish   951 --TKIIISTNIAETSVTIDDVVYVIDSGRMKEKRYDASRSMESLEDVWVSRANALQRKGRAGRVA 1013

  Fly   411 PGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGID-----DLVHFDFMDPPAPETLM 470
            .|.||.|:|...|::.:.....|||.|..|..:.|::|.|.:.     |.|....::||...:|.
Zfish  1014 SGVCFHLFTSHRFEHHLSQQQLPEIQRVPLEQLCLRVKVLEVFAERPLDSVFSQLIEPPTEGSLE 1078

  Fly   471 RALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVR 535
            .|.:.|..|.||.|:.:||.||..::..|:|.::.|:::......|.:..|:|.|.|:....||.
Zfish  1079 AAKQRLCALGALTDEESLTPLGWHLACLPVDVRIGKLMLLGAIFRCLDPALTIAASLAFKSPFVS 1143

  Fly   536 PNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDP-----NWCYENFINFRSLKSADNVRQ 595
            |.:.::.|:|.|:.|:..:.|||.|:..|..:..:::..     .:|.|||::.|.|:....:::
Zfish  1144 PWDKREEANEKKLGFSLANSDHLALMQAYKGWCNAAQSGFKAGYQYCRENFLSIRGLQEIACLKR 1208

  Fly   596 QL---------------ARIMDRFNLRRTSTEFTSKDYYVNIRK--------ALVQGFFMQVAHL 637
            |.               ||::::.:.:.:.....:..|..|:..        .|....:..|..:
Zfish  1209 QFAELLSDIGFVKDGLKARVIEKMSSKGSDGVLEATGYEANLNSDNTKLMSAMLCAALYPNVVQV 1273

  Fly   638 E--RTGYYLTIKDNQNVQ-----------------LHPS----TCLDHKPDWVIYNEFVLTTKNY 679
            .  :..|.||.|....:|                 :|||    :...:...:::|:|.|.|::.:
Zfish  1274 RSPQMKYKLTSKGAMKMQPKAEEQRFMTKSDGAVHIHPSSVNFSVRHYDSPYLVYHEKVKTSRVF 1338

  Fly   680 IRTVTDVKPEWLCCLAP 696
            ||..:      :.|:.|
Zfish  1339 IRDCS------MVCVYP 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	13/42 (31%)
		DEXDc	67..255	CDD:214692	84/191 (44%)
		DEXDc	91..228	CDD:238005	63/140 (45%)
		HELICc	315..408	CDD:197757	43/95 (45%)
		HA2	478..561	CDD:214852	26/82 (32%)
		OB_NTP_bind	595..698	CDD:285018	23/148 (16%)
dhx57	XP_001921063.3	UBA_like_SF	199..240	CDD:328731
		MOT2	<310..511	CDD:227502
		HrpA	538..1420	CDD:224557	226/797 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900