DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and CG3225

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_608860.1	Gene:	CG3225 / 33680	FlyBaseID:	FBgn0031631	Length:	678	Species:	Drosophila melanogaster

Alignment Length:	677	Identity:	270/677 - (39%)
Similarity:	415/677 - (61%)	Gaps:	38/677 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 QPPTMNPLTNTPYSQRYQN-----------LYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGS 99
            :|.|.:.:|::...::..:           |.::|..||:.:|:...:..|..||.::|||||||
  Fly    10 KPETDDAITDSAGGEQQSSAFVFNVNHNMGLMEQRERLPIRQYRDQILYCLEKHQVVILVGETGS 74

  Fly   100 GKTTQIPQWCVDFA-VSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAK 163
            ||:||:||:..::. .:||..|:  |:||||:.:::|.||::|....:|:.|||.:||.:..::.
  Fly    75 GKSTQVPQYLYEWGWHTKGLIGI--TEPRRVSTVTLANRVAQERGELVGDTVGYVVRFLESMSSC 137

  Fly   164 TLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATL 228
            |.:|:||:|:||||.::||:|.||.||::||||||.:.||:::|:||:::|:||.|||::.|||:
  Fly   138 TKIKFMTEGILLREVLADPLLTQYGVIIVDEAHERNMLTDMILGLLKKILRKRSSLKLIISSATI 202

  Fly   229 DAGKFQQYF------DNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILM 287
            ||..|.::|      :.:..:.:.||.|||..||..||..||::..:.||.::|. :|..||||.
  Fly   203 DASFFSEFFSWPGSGEVSVKLSIEGRMHPVSNFYLNEPCADYVKETVETVWKLHQ-KEPPGDILA 266

  Fly   288 FLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVV 352
            |||||||:.||...::..|  ..||...||.:|:|.::....|..:|  ..||...    ||||:
  Fly   267 FLTGQEEVLEALDLLREYI--ASSEQENLKVLPMYGSMSSTDQLSVF--FTPPKGT----RKVVL 323

  Fly   353 STNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRL 417
            :|||||||:||.|:|:|||.|:.|.|.|||:...:||::.|:|||||.||:|||||.||||.:||
  Fly   324 ATNIAETSITIPGIVYVIDCGYVKVKWYNPKTCSDSLVIVPVSKASAIQRAGRAGRMRPGKVYRL 388

  Fly   418 YTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAAL 482
            ||:..:: .:.....||:.||.|...:||||.|||.:::.|||..||..:.|:.|||.|..|.|:
  Fly   389 YTKSDYE-ALAPRQPPEMRRSELSGAILQLKALGIGNILRFDFPSPPPAQNLLSALESLFALDAI 452

  Fly   483 DDDGNLT-DLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNE--AKKAAD 544
            |:.|||| .:|.:::|.|....|:|||..|.|..||.||::|.|:|.|...|.||..  |:::..
  Fly   453 DEQGNLTKPVGYLLAELPFSAMLSKMLYVSGQMGCSEEIITIIALLQVQSIFSRPASAVAQQSGR 517

  Fly   545 EAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRFNLRRT 609
            .|..:|...:||.:|:||.|..|.:......:|.:.|:.:|:||.|.::|:||..:..:   :..
  Fly   518 IAHRKFEVAEGDFITMLNAYTGFVEEGMTKEFCGQYFLIYRNLKRAHSLREQLITVARK---KYG 579

  Fly   610 STEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCLDHKP--DWVIYNEF 672
            ...|:.|.....:.|.:..|||.|||:|..:|.|..|.....:.:||::.|...|  .:|:|.|.
  Fly   580 IPIFSCKGDVEKLCKCITAGFFTQVAYLHHSGVYRQISSGTELAIHPNSTLYTLPQAQYVVYGEL 644

  Fly   673 VLTTKNYIRTVTDVKPEWLCCLAPQYY 699
            :.|||.::..||.:|.|||..|||.||
  Fly   645 LQTTKLFMNYVTVIKREWLTELAPHYY 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	17/62 (27%)
		DEXDc	67..255	CDD:214692	83/194 (43%)
		DEXDc	91..228	CDD:238005	66/137 (48%)
		HELICc	315..408	CDD:197757	45/92 (49%)
		HA2	478..561	CDD:214852	33/85 (39%)
		OB_NTP_bind	595..698	CDD:285018	34/104 (33%)
CG3225	NP_608860.1	HrpA	40..668	CDD:224557	263/642 (41%)
		DEXDc	64..202	CDD:238005	67/139 (48%)
		HELICc	289..380	CDD:197757	47/96 (49%)
		HA2	448..534	CDD:214852	33/85 (39%)
		OB_NTP_bind	<581..670	CDD:285018	32/88 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468062
Domainoid	1	1.000	96	1.000	Domainoid score	I378
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D13788at6656
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		otm51353
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.800