DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and dhx16

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_956318.1	Gene:	dhx16 / 336645	ZFINID:	ZDB-GENE-030131-8589	Length:	1054	Species:	Danio rerio

Alignment Length:	701	Identity:	355/701 - (50%)
Similarity:	478/701 - (68%)	Gaps:	34/701 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SSAAAAAGTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQ 89
            |:|....||:::       .:..|.::..     .::.|::.:.|.:||:|.|:.|.:..:..||
Zfish   377 STAITMKGTLSE-------KESEPELSQA-----EKQKQSIQEVRRSLPIFPYREDLLAAIGDHQ 429

  Fly    90 CIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSI 154
            .:|:.|||||||||||||:.::...:||...:.|||||||||||||.||::||.||||.||||||
Zfish   430 ILVIEGETGSGKTTQIPQYLLEEGYTKGGMKIGCTQPRRVAAMSVAARVAQEMSVKLGNEVGYSI 494

  Fly   155 RFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDL 219
            |||||::.:|:||||||||||||.:::|.|..|.||::||||||||.||||.|::|::.|.|.||
Zfish   495 RFEDCTSERTILKYMTDGMLLREFLTEPDLASYSVIIIDEAHERTLHTDILFGLIKDIARFRPDL 559

  Fly   220 KLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGD 284
            |::|.|||||..:|..:||:||:.::|||..||:|:||..||.|||||.:.:|:|||:.:. .||
Zfish   560 KVLVASATLDTERFSSFFDDAPVFRIPGRRFPVDIYYTKAPEADYLEACVVSVLQIHVTQS-PGD 623

  Fly   285 ILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRK 349
            :|:|||||||||..|:.::.....|||:|.||..:|:|:.||.::|.:||.|.||    ||  ||
Zfish   624 VLVFLTGQEEIEACCELLQERCRRLGSKISELLVLPIYANLPSDMQAKIFNPTPP----GA--RK 682

  Fly   350 VVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKC 414
            |||:||||||||||||:::||||||.|||.||.:..:|||:|:|.|:|||.||:|||||...|||
Zfish   683 VVVATNIAETSLTIDGIIYVIDPGFCKQKSYNAKTGMESLIVTPCSRASANQRAGRAGRVAAGKC 747

  Fly   415 FRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYL 479
            |||||..|||:||::.|.|||.|:|||.|||.||.|||:||:||||||||..|||:.|||.|..|
Zfish   748 FRLYTAWAFKHEMEETTVPEIQRTNLGNVVLLLKSLGINDLIHFDFMDPPPHETLVLALEQLYAL 812

  Fly   480 AALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSV-PQCFVRPNEAKKAA 543
            .||:..|.||.||..|:|.|:||.|:||::||.|:.||.|:|:|.||||| ...|.||.:....|
Zfish   813 GALNHLGELTKLGRRMAELPVDPMLSKMILASEQYKCSEEVLTIAAMLSVNNSIFYRPKDKVVHA 877

  Fly   544 DEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRFNLRR 608
            |.|:|.|....||||.|||||..:.:|.....||:||||.|||:|.|.:||.||..:|||..:..
Zfish   878 DNARMNFVVPGGDHLVLLNVYTQWVESGYSTQWCFENFIQFRSMKRARDVRDQLEGLMDRIEVEL 942

  Fly   609 TSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCL-DHKPDWVIYNEF 672
            .|:...|    :.||||:..|:|...|.|.:.| |.|:|..|.|.:||::.| :.:|.|:||:|.
Zfish   943 CSSNGDS----MPIRKAVTAGYFYHTARLSKGG-YKTVKHQQTVYVHPNSSLFEEQPRWMIYHEL 1002

  Fly   673 VLTTKNYIRTVTDVKPEWLCCLAPQYY--------DLNNFPQCEAKRQLEL 715
            |.|||.::|.|.:::..||..:||.||        .....|:.:.|.:.||
Zfish  1003 VFTTKEFMRQVIEIESGWLLEVAPHYYKNKELEDSSSKKMPRKQGKAREEL 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	16/51 (31%)
		DEXDc	67..255	CDD:214692	109/187 (58%)
		DEXDc	91..228	CDD:238005	88/136 (65%)
		HELICc	315..408	CDD:197757	56/92 (61%)
		HA2	478..561	CDD:214852	41/83 (49%)
		OB_NTP_bind	595..698	CDD:285018	39/103 (38%)
dhx16	NP_956318.1	BLVR	<94..>142	CDD:283923
		GBP_C	<177..296	CDD:303769
		coiled coil	271..285	CDD:293879
		DEXDc	407..594	CDD:214692	109/186 (59%)
		DEXDc	429..568	CDD:238005	89/138 (64%)
		Helicase_C	612..742	CDD:278689	78/136 (57%)
		HA2	811..895	CDD:214852	41/83 (49%)
		OB_NTP_bind	916..1028	CDD:285018	47/116 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.730