DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and CG8915

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001285369.1	Gene:	CG8915 / 32715	FlyBaseID:	FBgn0030833	Length:	976	Species:	Drosophila melanogaster

Alignment Length:	824	Identity:	228/824 - (27%)
Similarity:	386/824 - (46%)	Gaps:	151/824 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRRI--EVGETYGSKAK-KDPEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQN 64
            :||:  .||:...:|.: ||....|:     .|.|.|.|       .||        |.|.|.:|
  Fly   157 ERRLMNSVGDLKCNKQQYKDIRLPSN-----FGLVGQRL-------IPP--------PQSNRNRN 201

  Fly    65 LYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVS-KGRKGVSCTQPRR 128
            :..:|.:||:::.:...:.:|...|.:::.|.|||||:||:||:.:::|.. :....:..:||||
  Fly   202 IQHERRSLPIYKQRESILNVLQRDQVLIIKGATGSGKSTQLPQYILEWAAEHRAPVRIVVSQPRR 266

  Fly   129 VAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSD--PMLDQYQVIL 191
            :||:||::|:|:|.....|..|||:||.....::.|:|...|.|.|||....|  ........::
  Fly   267 IAAISVSERISKERGEAPGTTVGYNIRMNRQCSSNTVLMLTTSGCLLRALAMDKKSFFKNTTHLI 331

  Fly   192 LDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFY 256
            :||||||.|.||.|:...|..:::...|:||:||||:|......||....:|.|.||:..|.|::
  Fly   332 IDEAHERDLDTDFLLLATKLELQKNPHLRLVLMSATMDLEALSNYFGGGTVMDVEGRSFEVSIYH 396

  Fly   257 --------------------------TP--------------EPERDYLEAAIRTVIQIHMCEEI 281
                                      ||              .|:.|  ...|.:::::.:.:..
  Fly   397 LEDILSKTGYMHPRMEKFLGKPTGKETPSELLAAYYGGNTIVHPDID--NDLIVSLLELLLRQGD 459

  Fly   282 EGDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAI 346
            .|.::::|.|..::.....|::..:..     .::..|.|:|.:..:.|:::|...|      .:
  Fly   460 AGAVIVYLPGYSDMTSLLARLESSLPR-----EQITIILLHSQVDNSEQRKVFRTYP------GV 513

  Fly   347 GRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRP 411
            ..|:::||||.:||:||..:::|||.|.||.|.|:..|....|.::.||:|.|:||:|||||...
  Fly   514 RLKIILSTNIGQTSITIPDLLYVIDTGLAKMKTYDSTIDASQLTLTWISQADAKQRAGRAGRVCH 578

  Fly   412 GKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDF----MDPPAPETLMRA 472
            |.|:|||...... .|...|.|||:|..|..:.| |.||...|....:|    :|.|..:.:|::
  Fly   579 GNCYRLYDNDRMA-RMNLYTIPEIMRRTLDEICL-LTKLAAPDKKIENFLALALDTPPKDAVMQS 641

  Fly   473 LELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPN 537
            ...|..|..||:...:|.||.:::|.||..|:.|.|:.|....|.:.::.|.|..||...||...
  Fly   642 CSRLKLLGVLDERDEVTPLGHIVAELPLGVQIGKCLVYSIYLRCLDSMIIIAAYHSVRDPFVLNI 706

  Fly   538 E-AKKAADE-AKMRFAHIDG--DHLTLLNVYHAFK--QSSEDPNWCYENFINFRSLK----SADN 592
            | .||:..: :::.||. ||  |.|.::.:|..|.  :..:..::|..|||...:::    :|..
  Fly   707 ERGKKSGQQISRVLFAG-DGMSDSLAVIKLYEEFTNLKRKDIGDFCERNFICRNAMEMFVSAAST 770

  Fly   593 VRQQLARIMDRFN--LRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQN---- 651
            :|..:.||. ||:  ..|.::.|.:....  ||.||..|.:.::|:::|        :|:|
  Fly   771 LRDTVYRIF-RFSEASARLASSFNNDTNM--IRLALTAGLYPKLAYMDR--------ENKNQLVA 824

  Fly   652 -----VQLHPSTCL-------DHKPDWVIYNEFVLTTKNYI-------------------RTVTD 685
                 ||:..|:||       |...:|:::.|...|.....                   |.:|:
  Fly   825 EGDPLVQVSRSSCLRGKKKQKDLASEWILFVEKTRTADQISSLEHTTLVSGLMVALAGGKRFITE 889

  Fly   686 VK-PEWLCCLAPQYYDLNNFPQCEAKRQLELLQQRLET-KQYQK 727
            .. .|.|.|| ..:..|    :|.|:..|:|.:.|:.| :::.|
  Fly   890 AHGSEMLLCL-DSWIRL----KCPAEFGLQLHKVRMLTDREFAK 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	14/51 (27%)
		DEXDc	67..255	CDD:214692	67/190 (35%)
		DEXDc	91..228	CDD:238005	53/139 (38%)
		HELICc	315..408	CDD:197757	34/92 (37%)
		HA2	478..561	CDD:214852	29/86 (34%)
		OB_NTP_bind	595..698	CDD:285018	30/140 (21%)
CG8915	NP_001285369.1	R3H	64..123	CDD:100064
		DEXDc	214..395	CDD:214692	64/180 (36%)
		DEXDc	226..368	CDD:238005	54/141 (38%)
		HELICc	479..575	CDD:197757	35/106 (33%)
		HA2	648..733	CDD:214852	29/85 (34%)
		OB_NTP_bind	783..884	CDD:285018	20/110 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840