DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and l(1)G0007

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_572947.1	Gene:	l(1)G0007 / 32373	FlyBaseID:	FBgn0026713	Length:	1222	Species:	Drosophila melanogaster

Alignment Length:	678	Identity:	301/678 - (44%)
Similarity:	450/678 - (66%)	Gaps:	28/678 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 RYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSCTQ 125
            |.:.:.::|..||||..:.:.:.::..:..|::|||||||||||:.|:..:...|| |..:.|||
  Fly   523 RKKTISEQRRFLPVFASRQELLNVIRENSVIIIVGETGSGKTTQLTQYLHEDGYSK-RGMIGCTQ 586

  Fly   126 PRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVI 190
            ||||||||||:|||:|||.:|||:|||:||||||::.:|::||||||:||||::.||.||.|..|
  Fly   587 PRRVAAMSVAKRVSDEMDTQLGEDVGYAIRFEDCTSERTVIKYMTDGILLRESLRDPELDSYSAI 651

  Fly   191 LLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIF 255
            ::||||||:|:||:|.|:|:|::.:|.||||:|.|||:|:.||..:|.|.|...:||||.||::.
  Fly   652 IMDEAHERSLSTDVLFGLLREIVARRHDLKLIVTSATMDSSKFATFFGNVPTFTIPGRTFPVDVM 716

  Fly   256 YTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKR---EIDNLGSEIGELK 317
            ::.....||:|:|::..:|:|:... |||:|:|:.|||:||..|:.::.   ||||..:    |.
  Fly   717 FSKNTCEDYVESAVKQALQVHLTPN-EGDMLIFMPGQEDIEVTCEVLEERLAEIDNAPA----LS 776

  Fly   318 CIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNP 382
            .:|:||.||.:||.:||:    .:::|.  ||.||:|||||||||:||:::|||.|:.|.|||||
  Fly   777 ILPIYSQLPSDLQAKIFQ----KSSDGL--RKCVVATNIAETSLTVDGIIYVIDSGYCKLKVYNP 835

  Fly   383 RIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQL 447
            ||.:::|.:.|||:|:|.|||||||||.||:.:||||::.:|:|:...|.|||.|:||...||.|
  Fly   836 RIGMDALQIYPISQANANQRSGRAGRTGPGQAYRLYTQRQYKDELLALTVPEIQRTNLANTVLLL 900

  Fly   448 KKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASC 512
            |.||:.||:.|.|||||..:.::.:|..|..|.|||..|.||.||..|:||||||...:|||.:|
  Fly   901 KSLGVVDLLQFHFMDPPPQDNILNSLYQLWILGALDHTGALTTLGRQMAEFPLDPPQCQMLIVAC 965

  Fly   513 QHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWC 577
            :..||.|:|.|.:|||||..|.||...:..||..:.:|...:.||||.||||..::|::....||
  Fly   966 RMGCSAEVLIIVSMLSVPSIFYRPKGREDEADGVREKFQRPESDHLTYLNVYQQWRQNNYSSTWC 1030

  Fly   578 YENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGY 642
            .|:||:.::::....|||||..||.:.||...|...   |:.: :||.:...:|.|.|.|:..|.
  Fly  1031 NEHFIHIKAMRKVREVRQQLKDIMTQQNLSVISCGI---DWDI-VRKCICSAYFYQAARLKGIGE 1091

  Fly   643 YLTIKDNQNVQLHPSTC---LDHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDLNNF 704
            |:.::......|||::.   |...||:|:|:|.::|.|.|::..|.|...||..|.|.::.:...
  Fly  1092 YVNLRTGMPCHLHPTSALYGLGTTPDYVVYHELIMTAKEYMQCATAVDGYWLAELGPMFFSVKES 1156

  Fly   705 PQC--EAKRQ----LELLQQRLETKQYQ 726
            .:.  |.|:|    |:.:::::...|::
  Fly  1157 GRSGREKKKQAAEHLKEMEEQMLKAQHE 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	14/40 (35%)
		DEXDc	67..255	CDD:214692	103/187 (55%)
		DEXDc	91..228	CDD:238005	85/136 (63%)
		HELICc	315..408	CDD:197757	50/92 (54%)
		HA2	478..561	CDD:214852	40/82 (49%)
		OB_NTP_bind	595..698	CDD:285018	35/105 (33%)
l(1)G0007	NP_572947.1	DEXDc	529..715	CDD:214692	103/186 (55%)
		DEXDc	551..689	CDD:238005	85/138 (62%)
		HELICc	722..870	CDD:238034	76/158 (48%)
		HA2	932..1014	CDD:214852	40/81 (49%)
		OB_NTP_bind	1048..1148	CDD:285018	34/103 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468067
Domainoid	1	1.000	158	1.000	Domainoid score	I178
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	234	1.000	Inparanoid score	I130
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		otm51353
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X141
	11	10.800