DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and dhx15

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001108613.1	Gene:	dhx15 / 321931	ZFINID:	ZDB-GENE-030131-650	Length:	769	Species:	Danio rerio

Alignment Length:	770	Identity:	572/770 - (74%)
Similarity:	654/770 - (84%)	Gaps:	45/770 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKR-RIEVGETYGSKAKKDPEA-------------------------------------SSSSA 27
            |||| |:::|:.|.|..|:..:.                                     |.||:
Zfish     1 MSKRHRLDLGDEYSSSKKRSSDGKDRDRDRDERSKDRDRDRDRERDRDRDRDRDRDRERDSKSSS 65

  Fly    28 AAAAGTVAQILGGFVPNKQP---PTMNPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQ 89
            ||.:.:|:.  .|.:|.||.   ..:||.||.|::.||..:.|||:.|||:||:..|..:|:.||
Zfish    66 AALSSSVSG--SGILPLKQASMHQQINPFTNLPHTPRYYEILKKRLQLPVWEYKERFNDILNRHQ 128

  Fly    90 CIVLVGETGSGKTTQIPQWCVDF--AVSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGY 152
            ..||||||||||||||||||||.  ::...::||:||||||||||||||||::||||.||:||||
Zfish   129 SFVLVGETGSGKTTQIPQWCVDMVRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGY 193

  Fly   153 SIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRS 217
            ||||||||:|||:||||||||||||||:||:|::|.||:|||||||||||||||||||||:||||
Zfish   194 SIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRS 258

  Fly   218 DLKLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIE 282
            |||::||||||||||||.||||.||:.:|||||||||||||||||||||||||||||||||||.|
Zfish   259 DLKVIVMSATLDAGKFQVYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEDE 323

  Fly   283 GDILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIG 347
            ||:|:||||||||:|||||||||||:||.::|::|.|||||||||..|||||||.||...|||||
Zfish   324 GDVLLFLTGQEEIDEACKRIKREIDDLGPDVGDIKIIPLYSTLPPQQQQRIFEPPPPRKPNGAIG 388

  Fly   348 RKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPG 412
            ||||||||||||||||||||||||||||||||||||||||||||:.|||||||||:|||||||||
Zfish   389 RKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPG 453

  Fly   413 KCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLN 477
            ||||||||||:|.||||||||||||||||:|||||||||||||||||||||||||||||||||||
Zfish   454 KCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLN 518

  Fly   478 YLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKA 542
            |||||:|||:||:||::|:|||||||||||:||||..|||||:||||||||||||||||.|||||
Zfish   519 YLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDFNCSNEVLSITAMLSVPQCFVRPTEAKKA 583

  Fly   543 ADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRFNLR 607
            |||:|||||||||||||||||||||||:.|...|||:||||:|||.|||||||||:||||||||.
Zfish   584 ADESKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLP 648

  Fly   608 RTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCLDHKPDWVIYNEF 672
            |.||||||:|||:|||:|||.|||||||||||||:|||:||||.|||||||.|||||:||:||||
Zfish   649 RRSTEFTSRDYYINIRRALVTGFFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEF 713

  Fly   673 VLTTKNYIRTVTDVKPEWLCCLAPQYYDLNNFPQCEAKRQLELLQQRLETKQYQK 727
            ||||||||||.||:|||||..:|||||:::||||||||||||.:..:|:||:|.:
Zfish   714 VLTTKNYIRTCTDIKPEWLVKIAPQYYEMSNFPQCEAKRQLERIVAKLQTKEYSQ 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	28/51 (55%)
		DEXDc	67..255	CDD:214692	145/189 (77%)
		DEXDc	91..228	CDD:238005	111/138 (80%)
		HELICc	315..408	CDD:197757	80/92 (87%)
		HA2	478..561	CDD:214852	70/82 (85%)
		OB_NTP_bind	595..698	CDD:285018	84/102 (82%)
dhx15	NP_001108613.1	DEXDc	105..296	CDD:214692	145/190 (76%)
		DEXDc	128..269	CDD:238005	112/140 (80%)
		HELICc	356..449	CDD:197757	80/92 (87%)
		HA2	519..602	CDD:214852	70/82 (85%)
		OB_NTP_bind	636..739	CDD:285018	84/102 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596580
Domainoid	1	1.000	240	1.000	Domainoid score	I2221
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1040
Inparanoid	1	1.050	1147	1.000	Inparanoid score	I204
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	1	1.000	-	-		oto41044
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R312
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800