DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and kz

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001284815.1	Gene:	kz / 31205	FlyBaseID:	FBgn0001330	Length:	1192	Species:	Drosophila melanogaster

Alignment Length:	912	Identity:	262/912 - (28%)
Similarity:	401/912 - (43%)	Gaps:	218/912 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKRRIEVGETYGSKAKK---------------------DPEASSSSAAAAAGTVAQILGGFVPNK 45
            |||::.|.|....:||:                     |.||.:.||..|..|...|....:..|
  Fly   159 SKRKLLVEEEEELQAKRKNPNVISVEEDDEDSSSSDEDDEEAPAQSAPIAIPTPVSIAPPQIAVK 223

  Fly    46 QP-----PTMNP---LTNTPY--SQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSG 100
            .|     |..||   :..|.|  ..|...:...|:.||:...:...|..::.:..:::.||||||
  Fly   224 PPIKKLKPEPNPPACIHQTVYVPVHRTTEVQNARLRLPILAEEQQVMETINENPIVIVAGETGSG 288

  Fly   101 KTTQIPQWCVDFAVSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTL 165
            ||||:||:..:...:: .|.:..|:||||||:::::||:.||::. ..||.|.||||...|..|.
  Fly   289 KTTQLPQFLYEAGYAQ-HKMIGVTEPRRVAAIAMSKRVAHEMNLP-ESEVSYLIRFEGNVTPATR 351

  Fly   166 LKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVI----RQRSDLKLVVMSA 226
            :|:||||:||:|..:|.:|.:|.||:|||||||::.||||:|:|..::    ::...|||::|||
  Fly   352 IKFMTDGVLLKEIETDFLLSKYSVIILDEAHERSVYTDILVGLLSRIVPLRHKRGQPLKLIIMSA 416

  Fly   227 TLDAGKFQQ----YFDNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILM 287
            ||....|.:    :....||:||..|..||.|.:......||:..|.|..::||. :..||.||:
  Fly   417 TLRVSDFTENTRLFKIPPPLLKVEARQFPVTIHFQKRTPDDYVAEAYRKTLKIHN-KLPEGGILI 480

  Fly   288 FLTGQEEIEEACKRIKR-------------------------EIDNLGSEIGELK---------- 317
            |:|||:|:.:..::::|                         .||:..|.:.:.|
  Fly   481 FVTGQQEVNQLVRKLRRTFPYHHAPTKDVAKNGKVSEEEKEETIDDAASTVEDPKELEFDMKRVI 545

  Fly   318 ----------------------------------------------------------------- 317

  Fly   546 RNIRKSKKKFLAQMALPKINLDDYKLPGDDTEADMHEQPDEDDEQEGLEEDNDDELGLEDESGMG 610

  Fly   318 --------CIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGF 374
                    .:||||.|....|.|||.|.|    :|.  |..|||||:|||||||..:.:|:|.|.
  Fly   611 SGQRQPLWVLPLYSLLSSEKQNRIFLPVP----DGC--RLCVVSTNVAETSLTIPHIKYVVDCGR 669

  Fly   375 AKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSN 439
            .|.::|:....|.:.:|:..|||||.||:|||||...|.|:|||:...:.:..:|.:.|:|.:..
  Fly   670 QKTRLYDKLTGVSAFVVTYTSKASADQRAGRAGRISAGHCYRLYSSAVYNDCFEDFSQPDIQKKP 734

  Fly   440 LGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALD----DDGNL----TDLGAVMS 496
            :..::||::.:|||.:|||.|..||....|..|...|..|.||:    ::.:|    |.||.|:|
  Fly   735 VEDLMLQMRCMGIDRVVHFPFPSPPDQVQLQAAERRLIVLGALEVAKTENTDLPPAVTRLGHVIS 799

  Fly   497 EFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFV-----RPNEAKKAADEAKMRF------ 550
            .||:.|:..|||..|.|.|.....:.:.|.|||.:..:     |..:....|:    ||
  Fly   800 RFPVAPRFGKMLALSHQQNLLPYTVCLVAALSVQEVLIETGVQRDEDVAPGAN----RFHRKRQS 860

  Fly   551 ------AHIDGDHLTLLNVYHAFKQSSED---PNWCYENFINFRSLKSADNVRQQLARIMDRFNL 606
                  ..:.||.:.||....|.:.:...   |.:|..|.:..:::.....:|.||.   :..||
  Fly   861 WAASGNYQLLGDPMVLLRAVGAAEYAGSQGRLPEFCAANGLRQKAMSEVRKLRVQLT---NEINL 922

  Fly   607 RRTSTEF-------TSKDYYVN-IRKALVQGFFMQVA------------HLERTGYYLTIKD-NQ 650
            ..:..|.       ...|.... :|:.|:.|...:||            ...|..|.....| .:
  Fly   923 NVSDVELGVDPELKPPTDAQARFLRQILLAGMGDRVARKVPLADIADKEERRRLKYAYNCADMEE 987

  Fly   651 NVQLHPSTCLDHK-PDWVIYNE-FVL----TTKNYIRTVTDVKPEWLCCLAPQYYDLNNFPQCEA 709
            ...||.|:.|..| |:||||.| :.|    :||.:||.:|.::||||....|...::....:..|
  Fly   988 PAFLHVSSVLRQKAPEWVIYQEAYELQNGDSTKMFIRGITAIEPEWLLLYVPLLCNIREVREDPA 1052

  Fly   710 KR 711
            .|
  Fly  1053 PR 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	15/56 (27%)
		DEXDc	67..255	CDD:214692	79/195 (41%)
		DEXDc	91..228	CDD:238005	65/140 (46%)
		HELICc	315..408	CDD:197757	43/175 (25%)
		HA2	478..561	CDD:214852	28/107 (26%)
		OB_NTP_bind	595..698	CDD:285018	36/129 (28%)
kz	NP_001284815.1	HrpA	237..1058	CDD:224557	242/834 (29%)
		DEXDc	279..418	CDD:238005	65/140 (46%)
		P-loop_NTPase	369..>500	CDD:304359	50/131 (38%)
		HELICc	619..704	CDD:197757	43/90 (48%)
		HA2	774..859	CDD:214852	26/88 (30%)
		OB_NTP_bind	915..1039	CDD:285018	35/126 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850