DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dhx15 and Dhx36

DIOPT Version :9

Sequence 1:NP_001260766.1 Gene:Dhx15 / 35654 FlyBaseID:FBgn0033160 Length:729 Species:Drosophila melanogaster
Sequence 2:NP_001101148.1 Gene:Dhx36 / 310461 RGDID:1308767 Length:1000 Species:Rattus norvegicus


Alignment Length:819 Identity:243/819 - (29%)
Similarity:386/819 - (47%) Gaps:164/819 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 GTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGE 96
            |...|:|......|..|            ||..:.:.|..||.:..|.:.:.|::.||..|:.||
  Rat   171 GLDQQLLEDLQKKKTDP------------RYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGE 223

  Fly    97 TGSGKTTQIPQWCVDFAVSKGRKG---VSCTQPRRVAAMSVAQRVSEEMDVKL--GEEVGYSIRF 156
            ||.|||||:.|:.:|..:.:|...   :.||||||::|:|||:||:.|.....  |...||.||.
  Rat   224 TGCGKTTQVTQFILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRL 288

  Fly   157 EDCSTAKT-LLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLK 220
            :.....|. .:.|.|.|::|:...||..|.....|:|||.|||.|.:|:||.|:|:::..|||||
  Rat   289 QSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLK 353

  Fly   221 LVVMSATLDAGKFQQYFDNAPLMKVPGRTHPV----------EIFYTPEPER------------- 262
            :::|||||:|.||.:||.|.|::.:||.|.||          :|.|.||.:.             
  Rat   354 VILMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYFPEQKEHRSQFKRGFMQGH 418

  Fly   263 ---------------------------------DYLEA---------AIRTVIQIHMCEEIEGDI 285
                                             |.||.         .|..:|:..:.||.:|.|
  Rat   419 VNRQEKEEKEAIYKERWPAYIKELQTRYSASTIDVLEMMDDDKVDLNLIAALIRYIVLEEEDGAI 483

  Fly   286 LMFLTGQEEIEEACKRIKREIDNLGSEI----GELKCIPLYSTLPPNLQQRIFEPAPPPNANGAI 346
            |:||.|.:.|...       .|.|.|::    .....|||:|.:|...|.::|:..||    |. 
  Rat   484 LVFLPGWDNISTL-------HDLLMSQVMFKSDRFLIIPLHSLMPTVNQTQVFKKTPP----GV- 536

  Fly   347 GRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRP 411
             ||:|::|||||||:|||.||:|||.|..|:..::.:..:.::....:|||:|:||.|||||.:|
  Rat   537 -RKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQP 600

  Fly   412 GKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHF--DFMDPPAPETLMRALE 474
            |.|:.||.... .:.:.|...|||||:.|..:.||:|.|.:..:.:|  ..||||:.|.::.:::
  Rat   601 GHCYHLYNGLR-ASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFLSRLMDPPSDEAVVLSIK 664

  Fly   475 LLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEA 539
            .|..|:|||....||.||..::..|::|.:.||::......|.:.:|:|.|.||....||.|...
  Rat   665 HLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGK 729

  Fly   540 KKAADEAKMRFA-HIDGDHLTLLNVYHAFKQSSE-----DPNWCYENFINFRSLKSADNVRQQLA 598
            :|.||..:...| ....||||::|.:..::::..     :.::|:|.|::..:|:...|::.|.|
  Rat   730 EKIADARRKELAKETRSDHLTVVNAFEGWEEAKRRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFA 794

  Fly   599 RIMDRFNLRRTSTEFTS----KDYYVNIR-------KALV-QGFFMQVAHL------ERTGYYLT 645
            ..:       ....|.|    ||...||.       ||:: .|.:.:||.:      :|....:.
  Rat   795 EHL-------LGAGFVSSRSPKDPKANINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVH 852

  Fly   646 IKDNQNVQLHPSTC----LDHKPDWVIYNEFVLTTKNYIRTVTDVKP------------------ 688
            .|.:..|.:||.:.    .|...:|:||:..:.|:..|:...|:|.|                  
  Rat   853 TKSDGLVSIHPKSVNVEQTDFHYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDKDQ 917

  Fly   689 ------EWLCCLAPQYYDLNNFPQCEAKRQLELLQQRLE 721
                  ||:...:|:  .:.:..:...|....|||:::|
  Rat   918 EIIAVDEWIVFQSPE--RIAHLVKGLRKELDILLQEKIE 954

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dhx15NP_001260766.1 Motor_domain 50..>102 CDD:277568 15/51 (29%)
DEXDc 67..255 CDD:214692 81/203 (40%)
DEXDc 91..228 CDD:238005 60/142 (42%)
HELICc 315..408 CDD:197757 39/92 (42%)
HA2 478..561 CDD:214852 29/83 (35%)
OB_NTP_bind 595..698 CDD:285018 30/148 (20%)
Dhx36NP_001101148.1 HrpA 187..893 CDD:224557 228/738 (31%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 257..309 18/51 (35%)
DEAH box. /evidence=ECO:0000255|PROSITE-ProRule:PRU00541 326..329 2/2 (100%)
RecA-like domain 2. /evidence=ECO:0000250|UniProtKB:Q05B79 379..620 73/254 (29%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 490..549 22/71 (31%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9H2U1 509..520 4/10 (40%)
WH domain. /evidence=ECO:0000250|UniProtKB:Q05B79 621..690 25/68 (37%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 630..689 19/58 (33%)
OB-fold-like subdomains. /evidence=ECO:0000250|UniProtKB:Q05B79 833..897 14/63 (22%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 841..852 1/10 (10%)
Necessary for interaction with single-stranded DNA at the 3'-end of the G4-DNA structure. /evidence=ECO:0000250|UniProtKB:Q05B79 862..892 8/29 (28%)
Necessary for nuclear and nucleolar caps localizations. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..192 7/32 (22%)
Required for the pre-miR-134 transport. /evidence=ECO:0000269|PubMed:23651854 1..96
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53
Required for recruitment to cytoplasmic stress granules. /evidence=ECO:0000250|UniProtKB:Q9H2U1 1..43
Required for G4-DNA-and G4-RNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H2U1 45..97
DSM (DHX36-specific motif). /evidence=ECO:0000250|UniProtKB:Q05B79, ECO:0000250|UniProtKB:Q9H2U1 45..67
RecA-like domain 1. /evidence=ECO:0000250|UniProtKB:Q05B79 98..378 83/218 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1643
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53574
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.