DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and Ythdc2

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	XP_038953178.1	Gene:	Ythdc2 / 307446	RGDID:	1563192	Length:	1434	Species:	Rattus norvegicus

Alignment Length:	909	Identity:	236/909 - (25%)
Similarity:	376/909 - (41%)	Gaps:	290/909 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 NPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVS 115
            |.:...|..:........|.:|||||.|.:.::::..::.:::||||||||||||||:.:|....
  Rat   176 NGIPQVPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFK 240

  Fly   116 KGRK-GVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAM 179
            .|.. .:.||||||:||::||:||:.|...::|:.:||.||.|...:.||||.:.|:|:|||..|
  Rat   241 NGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLM 305

  Fly   180 S-DPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLM 243
            : |..|.....:::||.|||...:|.|:..|::::::...|||::.||.||...|.:||.:.|::
  Rat   306 AGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVI 370

  Fly   244 KVPGRTHPV-EIF---------YT---------------------------------PEPER--- 262
            .:.||...| |:|         ||                                 ||.:|
  Rat   371 YIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRA 435

  Fly   263 ----------------------------------------------------------------- 262

  Rat   436 VASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTEN 500

  Fly   263 ---DY------------------------------------------------------------ 264
               ||
  Rat   501 VSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLES 565

  Fly   265 ----------------------LEAAIRTVIQ-----------------------IHMCEEIEGD 284
                                  |.|..|.:::                       .|.|:  .|.
  Rat   566 YSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCD--AGA 628

  Fly   285 ILMFLTGQEEIEEACKRI----KREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGA 345
            ||:||.|.:||.....||    ||..||    ....:...|:|.:..:.|:::.: .||...
  Rat   629 ILIFLPGYDEIVGLRDRILFDDKRFADN----THRYQVFMLHSNMQTSDQKKVLK-NPPAGV--- 685

  Fly   346 IGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTR 410
              ||:::||||||||:|::.||||||.|..|:|.::....|..|.:..||||||.||.|||||.|
  Rat   686 --RKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCR 748

  Fly   411 PGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFM----DPPAPETLMR 471
            ||.||||::...|:|.::..| ||:||..|..:.|..|.|...:....||:    :||....:..
  Rat   749 PGICFRLFSRLRFQNMLEFQT-PELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRN 812

  Fly   472 ALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRP 536
            |:::|..:.|:|...:||:||..:::.|::|.|.||::.:....|.:.||:|...|:....||.|
  Rat   813 AVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLP 877

  Fly   537 NEA--KKAADEAKMRF-AHIDGDHLTLLNVYHAFKQSSEDPNW----CYENFINFRSLKSADNVR 594
            .:|  |:||...:.|| |....||:.||..:.|::::..| .|    |.:||::..:::....:|
  Rat   878 TQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSD-GWERAFCEKNFLSQATMEIIIGMR 941

  Fly   595 QQL---------ARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQ 650
            .||         .|.....::|..:|  .|:::.| ::.|||.|.:..:.|::|....||....:
  Rat   942 TQLLGQLRASGFVRARGGGDIRDVNT--NSENWAV-VKAALVAGMYPNLVHVDRENVVLTGPKEK 1003

  Fly   651 NVQLHPSTCLDH-------------------KPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLA 695
            .|:.||::.|..                   ..||:||:|  :|..:.|..:.       ||.|
  Rat  1004 KVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDE--MTRAHRIANIR-------CCSA 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	16/50 (32%)
		DEXDc	67..255	CDD:214692	77/190 (41%)
		DEXDc	91..228	CDD:238005	60/138 (43%)
		HELICc	315..408	CDD:197757	38/92 (41%)
		HA2	478..561	CDD:214852	28/85 (33%)
		OB_NTP_bind	595..698	CDD:285018	29/129 (22%)
Ythdc2	XP_038953178.1	R3H_DEXH_helicase	50..108	CDD:100077
		HrpA	193..>1020	CDD:224557	224/843 (27%)
		DEXHc_YTHDC2	197..372	CDD:350745	72/174 (41%)
		ANK repeat	509..541	CDD:293786	0/31 (0%)
		ANK repeat	543..571	CDD:293786	0/27 (0%)
		OB_NTP_bind	975..1070	CDD:400182	22/93 (24%)
		YTH	1293..1422	CDD:410979
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910