Protein Alignment Dhx15 and Ythdc2

DIOPT Version :10

• Sequence 1: NP_610269.1
• Gene: Dhx15 / 35654
• FlyBaseID: FBgn0033160
• Length: 729
• Species: Drosophila melanogaster
• Sequence 2: NP_001414131.1
• Gene: Ythdc2 / 307446
• RGDID: 1563192
• Length: 1434
• Species: Rattus norvegicus
• Alignment Length: 909
• Identity: 236/909 - (25%)
• Similarity: 376/909 - (41%)
• Gaps: 290/909 - (31%)

  Fly    51 NPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVS 115
            |.:...|..:........|.:|||||.|.:.::::..::.:::||||||||||||||:.:|....
  Rat   176 NGIPQVPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFK 240

  Fly   116 KGRK-GVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAM 179
            .|.. .:.||||||:||::||:||:.|...::|:.:||.||.|...:.||||.:.|:|:|||..|
  Rat   241 NGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLM 305

  Fly   180 S-DPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPLM 243
            : |..|.....:::||.|||...:|.|:..|::::::...|||::.||.||...|.:||.:.|::
  Rat   306 AGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVI 370

  Fly   244 KVPGRTHPV-EIF---------YT---------------------------------PEPER--- 262
            .:.||...| |:|         ||                                 ||.:|
  Rat   371 YIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQREEKQQTTLTEWYSAQENTFKPESQRQRA 435

  Fly   263 ----------------------------------------------------------------- 262
                                                                             
  Rat   436 VASVSEEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDVDAFAQVFHLILTEN 500

  Fly   263 ---DY------------------------------------------------------------ 264
               ||
  Rat   501 VSVDYRHSETSATALMVAAGRGFTSQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLES 565

  Fly   265 ----------------------LEAAIRTVIQ-----------------------IHMCEEIEGD 284
                                  |.|..|.:::                       .|.|:  .|.
  Rat   566 YSASLEFGNLDESSLVQTNGNDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCD--AGA 628

  Fly   285 ILMFLTGQEEIEEACKRI----KREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGA 345
            ||:||.|.:||.....||    ||..||    ....:...|:|.:..:.|:::.: .||...
  Rat   629 ILIFLPGYDEIVGLRDRILFDDKRFADN----THRYQVFMLHSNMQTSDQKKVLK-NPPAGV--- 685

  Fly   346 IGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTR 410
              ||:::||||||||:|::.||||||.|..|:|.::....|..|.:..||||||.||.|||||.|
  Rat   686 --RKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCR 748

  Fly   411 PGKCFRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFM----DPPAPETLMR 471
            ||.||||::...|:|.::..| ||:||..|..:.|..|.|...:....||:    :||....:..
  Rat   749 PGICFRLFSRLRFQNMLEFQT-PELLRMPLQELCLHTKLLAPVNCTIADFLMKAPEPPPALIVRN 812

  Fly   472 ALELLNYLAALDDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRP 536
            |:::|..:.|:|...:||:||..:::.|::|.|.||::.:....|.:.||:|...|:....||.|
  Rat   813 AVQMLKTIDAMDAWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLP 877

  Fly   537 NEA--KKAADEAKMRF-AHIDGDHLTLLNVYHAFKQSSEDPNW----CYENFINFRSLKSADNVR 594
            .:|  |:||...:.|| |....||:.||..:.|::::..| .|    |.:||::..:::....:|
  Rat   878 TQASQKRAAMLCRKRFTAGTFSDHMALLRAFQAWQKARSD-GWERAFCEKNFLSQATMEIIIGMR 941

  Fly   595 QQL---------ARIMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQ 650
            .||         .|.....::|..:|  .|:::.| ::.|||.|.:..:.|::|....||....:
  Rat   942 TQLLGQLRASGFVRARGGGDIRDVNT--NSENWAV-VKAALVAGMYPNLVHVDRENVVLTGPKEK 1003

  Fly   651 NVQLHPSTCLDH-------------------KPDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLA 695
            .|:.||::.|..                   ..||:||:|  :|..:.|..:.       ||.|
  Rat  1004 KVRFHPTSVLSQPQYKKIPPANGQAAAIQALPTDWLIYDE--MTRAHRIANIR-------CCSA 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_610269.1	HrpA	71..>691	CDD:441249	230/883 (26%)
Ythdc2	NP_001414131.1	None