DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and Dhx16

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_997661.1	Gene:	Dhx16 / 294232	RGDID:	1302963	Length:	1044	Species:	Rattus norvegicus

Alignment Length:	679	Identity:	346/679 - (50%)
Similarity:	475/679 - (69%)	Gaps:	20/679 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGS 99
            ||:.|...|:..||.      :..:|:.:::...|.:||||.::.:.:..::.||.:::.|||||
  Rat   371 AQLQGDEEPSSGPPL------SAQAQQKESIQAVRRSLPVFPFREELLTAIANHQVLIIEGETGS 429

  Fly   100 GKTTQIPQWCVDFAVSKGRKGVSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKT 164
            ||||||||:..:...:|....::|||||||||||||.||:.||.||||.|||||||||||::.:|
  Rat   430 GKTTQIPQYLFEEGYTKKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTSERT 494

  Fly   165 LLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLD 229
            :|:||||||||||.:|:|.|..|.|:::||||||||.||||.|::|:|.|.|.:||::|.|||||
  Rat   495 VLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATLD 559

  Fly   230 AGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEE 294
            ..:|..:||:||:.::|||..||:||||..||.|||||.:.:|:|||:.:. .||||:|||||||
  Rat   560 TARFSAFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQP-PGDILVFLTGQEE 623

  Fly   295 IEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAET 359
            ||.||:.::.....|||:|.||..:|:|:.||.::|.|||:|.||    ||  |||||:||||||
  Rat   624 IEAACEMLQDRCRRLGSKIRELLVLPIYANLPSDMQARIFQPTPP----GA--RKVVVATNIAET 682

  Fly   360 SLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFK 424
            ||||:|:::|:||||.|||.||||..:|||.|:|.|||||.||:|||||...||||||||..|::
  Rat   683 SLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQ 747

  Fly   425 NEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLT 489
            :|:::.|.|||.|::||.|||.||.|||.||:||||:|||..|||:.|||.|..|.||:..|.||
  Rat   748 HELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELT 812

  Fly   490 DLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSV-PQCFVRPNEAKKAADEAKMRFAHI 553
            ..|..|:|.|:||.|:||::||.:::||.|||::.||||| ...|.||.:....||.|::.|...
  Rat   813 TSGRKMAELPVDPMLSKMILASEKYSCSEEILTVAAMLSVNNSIFYRPKDKVVHADNARVNFFLP 877

  Fly   554 DGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRFNLRRTSTEFTSKDY 618
            .||||.|||||..:.:|.....||||||:.|||::.|.:||:||..:::|..:..||.:    ..
  Rat   878 GGDHLVLLNVYTQWAESGYSSQWCYENFVQFRSMRRARDVREQLEGLLERVEVGLTSCQ----GD 938

  Fly   619 YVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCL-DHKPDWVIYNEFVLTTKNYIRT 682
            ||.:|||:..|:|...|.|.|:| |.|:|..|.|.:||::.| :.:|.|::|:|.|||||.::|.
  Rat   939 YVRVRKAITSGYFYHTARLTRSG-YRTVKQQQTVFIHPNSSLFEQQPRWLLYHELVLTTKEFMRQ 1002

  Fly   683 VTDVKPEWLCCLAPQYYDLNNFPQCEAKR 711
            |.:::..||..:||.||.........||:
  Rat  1003 VLEIESSWLLEVAPHYYKAKELEDPHAKK 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	14/51 (27%)
		DEXDc	67..255	CDD:214692	105/187 (56%)
		DEXDc	91..228	CDD:238005	85/136 (63%)
		HELICc	315..408	CDD:197757	58/92 (63%)
		HA2	478..561	CDD:214852	38/83 (46%)
		OB_NTP_bind	595..698	CDD:285018	39/103 (38%)
Dhx16	NP_997661.1	DEXDc	402..584	CDD:214692	104/181 (57%)
		DEXDc	419..558	CDD:238005	86/138 (62%)
		HELICc	583..740	CDD:238034	98/163 (60%)
		HA2	801..885	CDD:214852	38/83 (46%)
		OB_NTP_bind	920..1018	CDD:285018	39/102 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D113216at33208
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X141
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730