DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and Dhx37

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001099396.2	Gene:	Dhx37 / 288647	RGDID:	1306837	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	851	Identity:	256/851 - (30%)
Similarity:	394/851 - (46%)	Gaps:	197/851 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GSKAKKDPEASSSSAAAAAGTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIALPVFEY 77
            |:.|..:..||:...|.|               :|....|:..||..|      ::|:.||:...
  Rat   210 GTSAPPETPASAPPPALA---------------KPAVFIPVNRTPEMQ------EERLKLPILAE 253

  Fly    78 QADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFAVSKGRKGVSCTQPRRVAAMSVAQRVSEEM 142
            :...|..::.|..:::.||||||||||:||:..:...|.....:..|:||||||::::|||::||
  Rat   254 EQAIMEAVAEHPIVIVCGETGSGKTTQVPQFLYEAGYSSEDSIIGVTEPRRVAAVAMSQRVAKEM 318

  Fly   143 DVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMG 207
            ::. ...|.|.||:|...|.:|.:|:||||:||:|...|.:|.:|:|:::||||||::.||||:|
  Rat   319 NLS-HRVVSYQIRYEGNVTEETRIKFMTDGVLLKEIQKDFLLLKYKVVIIDEAHERSVYTDILLG 382

  Fly   208 VLKEVIRQRS----DLKLVVMSATLDAGKFQQ----YFDNAPLMKVPGRTHPVEIFYTPE-PERD 263
            :|..::..|:    .|||::|||||....|.|    :....|::||..|..||.:.:... |..|
  Rat   383 LLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTTPPPVIKVESRQFPVTVHFNKRTPLDD 447

  Fly   264 YLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKR------------------------ 304
            |.....|.|.:||.... .|.||:|||||.|:...|:|:::
  Rat   448 YSGECFRKVCKIHRMLP-AGGILVFLTGQAEVHALCRRLRKAFPIRCSQPQEMEEDSAEGMRRFK 511

  Fly   305 -----------------EIDN-----------------------LGSEI-----------GE--- 315
                             .:||                       |||::           ||
  Rat   512 KSRTRARKAQAMALPQINLDNYSVLPAGEGDEDREAEMDDEEEALGSDLDLDLGDSEANEGEQPD 576

  Fly   316 ----LKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAK 376
                |..:||||.|.|..|.::|:  |||...    |..|::||:|||||||.|:.:|:|.|..|
  Rat   577 ASLPLHVLPLYSLLAPEKQAQVFK--PPPEGT----RLCVIATNVAETSLTIPGIKYVVDCGKVK 635

  Fly   377 QKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILRSNLG 441
            ::.|:....|.|..|:.:|:|||.||:||||||.||.|:|||:...| .:.:....|||.|..:.
  Rat   636 KRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVF-GDFEQFPPPEITRRPVE 699

  Fly   442 TVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGN---------------LTDL 491
            .::||:|.|.|:.:::|.|..||:.|.|:.|.|||..|.||.....               :|.|
  Rat   700 DLILQMKALNIEKVINFPFPTPPSVEALIAAEELLIALGALQAPPKQERMKKLQMSQLSCPITAL 764

  Fly   492 GAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFV---RPNEAKKAADEAKMRFAHI 553
            |..||.||:.|:.||||..|.||.|....::|.|.::|.:.|.   ||..:::...|.|.|...:
  Rat   765 GRTMSTFPVAPRYAKMLALSQQHGCLPYTIAIVAAMTVRELFEELDRPAASEEELAELKGRRTRV 829

  Fly   554 D---------------GDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLAR---- 599
            .               ||.:.||....|.:.:...|.:|..|.:.::::.....:|.||..
  Rat   830 AQMKRTWAGQGASLKLGDLMVLLGAVGACEYAGCSPQFCQANGLRYKAMLEIRRLRGQLTTAVNA 894

  Fly   600 -------IMDRFNLRRTSTEFTSKDYYVNIRKALVQGFFMQVAHLER-------------TGYYL 644
                   .:|......|.::.|      .:|:.:..|.   ..||.|             ..|..
  Rat   895 VCPEAGLFLDPKMQPPTESQVT------YLRQIMAAGL---GDHLARRVQSEDLLDPKWKNAYKT 950

  Fly   645 TIKDNQNVQLHPSTCLDHK-PDWVIYNEFVLTTKNYIRTVTDVKPEWLCCLAPQYYDLNNFPQCE 708
            .:.|:. |.:|||:.|..: |::|:|.|.|.|||.|::.|:.|:.:|:..|.|.|        |:
  Rat   951 PLLDDP-VFIHPSSVLFRELPEFVVYQEIVETTKMYMKGVSTVEIQWIPSLLPSY--------CQ 1006

  Fly   709 AKRQLE 714
            ....||
  Rat  1007 FDAPLE 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	15/51 (29%)
		DEXDc	67..255	CDD:214692	78/195 (40%)
		DEXDc	91..228	CDD:238005	63/140 (45%)
		HELICc	315..408	CDD:197757	42/99 (42%)
		HA2	478..561	CDD:214852	30/115 (26%)
		OB_NTP_bind	595..698	CDD:285018	31/127 (24%)
Dhx37	NP_001099396.2	HrpA	236..1009	CDD:224557	246/805 (31%)
		DEXDc	267..407	CDD:238005	63/140 (45%)
		HELICc	578..667	CDD:197757	41/94 (44%)
		HA2	730..781	CDD:282288	17/50 (34%)
		HA2	761..852	CDD:214852	27/90 (30%)
		OB_NTP_bind	887..1004	CDD:285018	31/126 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820