DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dhx15 and Dhx33

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_001099272.1	Gene:	Dhx33 / 287464	RGDID:	1307239	Length:	698	Species:	Rattus norvegicus

Alignment Length:	679	Identity:	282/679 - (41%)
Similarity:	412/679 - (60%)	Gaps:	29/679 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AGTVAQILGGFVPNKQPPTMNPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVG 95
            ||:.....||   .:|.|.:...:.:||.:.   |..:|.:||:|..:...:..|......||:|
  Rat    30 AGSGGGAGGG---RRQTPPLAQPSASPYREA---LELQRRSLPIFRARGQLLAQLRNLDNAVLIG 88

  Fly    96 ETGSGKTTQIPQWCVDFAVSKGRKG-VSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDC 159
            ||||||||||||:..:..:|  |:| ::.||||||||:|:|.|||:|...:||:.|||::||||.
  Rat    89 ETGSGKTTQIPQYLYEGGIS--RQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDV 151

  Fly   160 STAKTLLKYMTDGMLLREAMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSD-----L 219
            ::..|.:|::|||||||||:||.:|.:|..::||||||||:.||:|.||:|...::|.:     |
  Rat   152 TSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPL 216

  Fly   220 KLVVMSATLDAGKFQQYFDNAPLMKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGD 284
            |::|||||:|...|.|||:.||::.:.||.||::||||.:|::|||.||:.:|.|||.......|
  Rat   217 KVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQIFYTKQPQQDYLHAALVSVFQIHQEAPSSQD 281

  Fly   285 ILMFLTGQEEIEEACKRIKREIDNLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRK 349
            ||:|||||||||...|..:....:|......:..:|||::||.:.|.|:|:.||...      ||
  Rat   282 ILVFLTGQEEIEAMSKTCRDIAKHLPDGCPSMLVLPLYASLPYSQQLRVFQGAPKGY------RK 340

  Fly   350 VVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKC 414
            |::||||||||:||.|:.:|:|.|..|.|.|||...:|.|.|..:||..|.||:|||||...|.|
  Rat   341 VIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGIC 405

  Fly   415 FRLYTEKAFKNEMQDNTYPEILRSNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYL 479
            :|||||..| ::.:....|||.|.||.:|:|||..:.:.:::.||||..|:|:.:..|:..|:.|
  Rat   406 YRLYTEDEF-DKFEKMAAPEIQRCNLASVMLQLLAMKVPNVLTFDFMSRPSPDHIEAAIAQLDLL 469

  Fly   480 AAL---DDDGNLTDLGAVMSEFPLDPQLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKK 541
            .||   ||...||.:|..|:.|||:|:.||.::.|.:.:|:.|||:|.::|||......|...:.
  Rat   470 GALEHKDDQLALTPIGRKMAAFPLEPKFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPARRD 534

  Fly   542 AADEAKMRFAHIDGDHLTLLNVYHAFKQSSEDPNWCYENFINFRSLKSADNVRQQLARIMDRFNL 606
            .....:.:|...:|||:||||:|..||....:.:||.|||:|.:::.....||.||..|.    |
  Rat   535 EVQSVRKKFISSEGDHITLLNIYRTFKNIGGNKDWCKENFVNSKNMLLVAEVRAQLRDIC----L 595

  Fly   607 RRTSTEFTSKDYYVNIRKALVQGFFMQVAHLERTGYYLTIKDNQNVQLHPSTCLDH-KPDWVIYN 670
            :.:....:|:....::|:.|....||..|.|:..|.|.|...:|.|.:|||:.|.| ||..|:|.
  Rat   596 KMSMPIMSSRGDMESVRRCLAHSLFMSTAELQPDGTYATTDTHQPVAIHPSSVLFHCKPACVVYT 660

  Fly   671 EFVLTTKNYIRTVTDVKPEWLCCLAPQYY 699
            ..:.|.|.|:|.:..|..|||...||.|:
  Rat   661 SLLYTNKCYMRDLCVVDAEWLYEAAPDYF 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	16/51 (31%)
		DEXDc	67..255	CDD:214692	94/193 (49%)
		DEXDc	91..228	CDD:238005	77/142 (54%)
		HELICc	315..408	CDD:197757	43/92 (47%)
		HA2	478..561	CDD:214852	30/85 (35%)
		OB_NTP_bind	595..698	CDD:285018	35/103 (34%)
Dhx33	NP_001099272.1	DEXDc	49..252	CDD:214692	97/207 (47%)
		DEXDc	83..225	CDD:238005	77/143 (54%)
		Helicase_C	282..399	CDD:278689	56/122 (46%)
		HA2	469..554	CDD:214852	30/84 (36%)
		OB_NTP_bind	588..688	CDD:285018	35/103 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53574
OrthoDB	1	1.010	-	-		D354219at2759
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100085
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.730