DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dhx15 and prh1

DIOPT Version :9

Sequence 1:	NP_001260766.1	Gene:	Dhx15 / 35654	FlyBaseID:	FBgn0033160	Length:	729	Species:	Drosophila melanogaster
Sequence 2:	NP_593091.1	Gene:	prh1 / 2541750	PomBaseID:	SPAC2G11.11c	Length:	719	Species:	Schizosaccharomyces pombe

Alignment Length:	721	Identity:	300/721 - (41%)
Similarity:	462/721 - (64%)	Gaps:	44/721 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKRRIEVGETYGSK-----AKKDPEASSSSAAAAAGTVA------------QILGGFVPNKQPP 48
            ::|:.:..|...|.:     .||:.:||.::...:..:|.            :::|.  .|..|.
pombe    14 ITKQNLTDGLVGGQRIKAPNKKKNRKASKNTTKKSTVSVVNFLEQDTDFGANEVVGS--DNSSPE 76

  Fly    49 TMNPLTNTPYSQRYQNLYKKRIALPVFEYQADFMRLLSLHQCIVLVGETGSGKTTQIPQWCVDFA 113
            ..:  .|:| |:| :::.::|..||::|......:.:..::.||:||||||||:|||||:..:..
pombe    77 KRS--ENSP-SKR-KDILEQRKNLPIWEAHDTLCQQIQDNRVIVVVGETGSGKSTQIPQFLNECP 137

  Fly   114 VSKGRKG-VSCTQPRRVAAMSVAQRVSEEMDVKLGEEVGYSIRFEDCSTAKTLLKYMTDGMLLRE 177
            .:  ::| |:.||||||||:::|:||:.|...:|||:|||||||:|.::.||.:||:||||||||
pombe   138 YA--QEGCVAITQPRRVAAVNLAKRVAAEQGCRLGEQVGYSIRFDDTTSKKTRIKYLTDGMLLRE 200

  Fly   178 AMSDPMLDQYQVILLDEAHERTLATDILMGVLKEVIRQRSDLKLVVMSATLDAGKFQQYFDNAPL 242
            .::||:|.||..::|||||||||.||:|:|.:|::|::|..|::::|||||:|.:|.::||.|.:
pombe   201 LINDPILSQYHTLILDEAHERTLMTDMLLGFVKKIIKKRPALRVIIMSATLNAERFSEFFDGAEI 265

  Fly   243 MKVPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEIEGDILMFLTGQEEIEEACKRIKREID 307
            ..:.||.:||:|.||..||.|||:|.:||:.|:| .:...||||:|||||:|||.....||....
pombe   266 CYISGRQYPVQIHYTYTPEPDYLDACLRTIFQLH-TKLPPGDILVFLTGQDEIEALEALIKSYSK 329

  Fly   308 NLGSEIGELKCIPLYSTLPPNLQQRIFEPAPPPNANGAIGRKVVVSTNIAETSLTIDGVVFVIDP 372
            .|.|.:.:::..||:::||...|.::|.||.      |..||||:||||||||:||.|:.:|||.
pombe   330 QLPSNLPQIQACPLFASLPQEQQLQVFLPAL------ANHRKVVLSTNIAETSVTISGIRYVIDT 388

  Fly   373 GFAKQKVYNPRIRVESLLVSPISKASAQQRSGRAGRTRPGKCFRLYTEKAFKNEMQDNTYPEILR 437
            |.||.|.:|.::.:|||.|.|||:::|.||||||||...|:|:|:|||..| :::...|.|||.|
pombe   389 GLAKIKQFNSKLGLESLTVQPISQSAAMQRSGRAGREAAGQCYRIYTEADF-DKLPKETIPEIKR 452

  Fly   438 SNLGTVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALDDDGNLTDLGAVMSEFPLDP 502
            .:|...||.||..|.:|:::|.:||||:.|.|:||||.|..:.||||:|::.|||..||..||.|
pombe   453 IDLSQAVLTLKARGQNDVINFHYMDPPSKEGLLRALEHLYSIGALDDNGHINDLGYQMSLIPLLP 517

  Fly   503 QLAKMLIASCQHNCSNEILSITAMLSVPQCFVRPNEAKKAADEAKMRFAHIDGDHLTLLNVYHAF 567
            .||:.::|:.:|||.:|::.:.:.||....|:.|.|.:..|.||:::|.|.:||.||.||....:
pombe   518 SLARAVLAAREHNCLSEVIDVVSCLSTDSMFLFPQEKRDEAIEARLKFLHSEGDLLTCLNALRQY 582

  Fly   568 KQSSED--PNWCYENFINFRSLKSADNVRQQLAR--IMDRFNLRRTSTEFTSKDYYVNIRKALVQ 628
            .:||.|  ..||.:||||.|:||:..::|:||..  :.|.:.| .:|.|..|:    |:..:.:.
pombe   583 LESSHDSRKQWCSQNFINRRALKTILDIRKQLREHCLKDGWEL-NSSPEVNSE----NLLLSFLS 642

  Fly   629 GFFMQVAHLERTGYYLTIKDNQNVQLHPSTCL-DHKPDWVIYNEFVLTTKNYIRTVTDVKPEWLC 692
            |:....|.|...|.|.||..||.:.:|||:.| ..|.:.::|:|.|.|||:|:|.|:.::..||.
pombe   643 GYITNTALLHPDGSYRTIIGNQTISIHPSSSLFGKKVEAIMYHELVFTTKSYVRGVSSIRSNWLN 707

  Fly   693 CLAPQY 698
            .:||.|
pombe   708 AVAPHY 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dhx15	NP_001260766.1	Motor_domain	50..>102	CDD:277568	17/51 (33%)
		DEXDc	67..255	CDD:214692	92/188 (49%)
		DEXDc	91..228	CDD:238005	77/137 (56%)
		HELICc	315..408	CDD:197757	46/92 (50%)
		HA2	478..561	CDD:214852	34/82 (41%)
		OB_NTP_bind	595..698	CDD:285018	35/105 (33%)
prh1	NP_593091.1	HrpA	58..711	CDD:224557	289/673 (43%)
		DEXDc	113..251	CDD:238005	77/139 (55%)
		HELICc	276..433	CDD:238034	79/163 (48%)
		HA2	493..576	CDD:214852	34/82 (41%)
		OB_NTP_bind	601..713	CDD:285018	39/116 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810